DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and ABCA9

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	XP_024306297.1	Gene:	ABCA9 / 10350	HGNCID:	39	Length:	1634	Species:	Homo sapiens

Alignment Length:	905	Identity:	177/905 - (19%)
Similarity:	312/905 - (34%)	Gaps:	336/905 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 AVSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDAGEIFVL 137
            |:.:::..|.|..|....:.|..:...:.:|.|..|||.||.||||||:.:.|.....:|.:.|.
Human   488 AIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVY 552

  Fly   138 GGKPGTRGSGVP--GKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEILERLQFLLNFLDLP 200
             ....:|.:.:.  .|..|:.||....:|..:::|.:..|..|.|:...|:.:.:|.::..|::.
Human   553 -NHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEME 616

  Fly   201 S-EKRLVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQ--KTV 262
            : :..|.:||||||.|:::|.:|::.||::|:|||||.|:|||.|..|||    :.|.|:  :.:
Human   617 NIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWN----LLKEGKSDRVI 677

  Fly   263 IITTHYIEEA------------------------RQAHTIGLMRSGHLLAEESPSVLLSIYK--- 300
            :.:|.:|:||                        ::...||...|.||.....|..:.|:.|
Human   678 LFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPESITSLVKQHI 742

  Fly   301 ----------------------------------C------------ISLEEVFLKLSRIQSQKG 319
                                              |            .:|.||||||      :|
Human   743 SDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVSITTLNEVFLKL------EG 801

  Fly   320 DVTHVNFSNNISLHAMAFGSKMDKPSSSQEGGVVGL-----NFHQSKEVL--------------- 364
            ..|       |....:....::....:...|.:|.|     :||::::.:
Human   802 KST-------IDESDIGIWGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAK 859

  Fly   365 -----INDSNGSIYTL----------------------NQEPYSPPPSRRNNNPNDEESCQDCYS 402
                 :.....|::|:                      ...|:...|:....:|..:.  ||..:
Human   860 VRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNTYFLSPGQQP--QDPLT 922

  Fly   403 NLCKITSKGKIRALLTKNMLRMWRNVGVMLFIFALPVMQVILFCLAIGRDPQGLNLA-IVNGEMN 466
            :|..|...|.    ...|.|...|...:        .::|..|....|.|....|.| ||:|:..
Human   923 HLLVINKTGS----TIDNFLHSLRRQNI--------AIEVDAFGTRNGTDDPSYNGAIIVSGDEK 975

  Fly   467 DTVRENCYWEDGCHFKNLGC----------------RYLSHLNTSVVKTYYEDLDDAKEAVRKGT 515
            |.     .:...|:.|.|.|                ....|:.|. ..|::|:..|.:...|..|
Human   976 DH-----RFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTD-RSTFFEEHMDYEYGYRSNT 1034

  Fly   516 -AWGAVYISENFTDAFIARANLGRDSDDETIDSSEVKV--------WLDMSNQQIGVMLNRDIQL 571
             .|  :.::.:|| .:||.:::|   |.:....|::::        |
Human  1035 FFW--IPMAASFT-PYIAMSSIG---DYKKKAHSQLRISGLYPSAYW------------------ 1075

  Fly   572 AFRDFAMGLLGQCGSNPKLGDVPIQFRDPIYGTMNPSFTDFVAPGVILTIVFFLAVALTSSALII 636
                     .||.     |.||.:                           :||.:.|..
Human  1076 ---------FGQA-----LVDVSL---------------------------YFLILLLMQ----- 1094

  Fly   637 ERTEGLLDRSWVAGVSPFEILF--SHVITQFVVMCGQTTLVLIFMLVVFGVTNNG-------DLF 692
                 ::|..:    ||.||:|  .:::.|.:...|..:.::....|:..:..||       ..|
Human  1095 -----IMDYIF----SPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFF 1150

  Fly   693 WVIVLTLLQGMCGMCFGFLISSVCELERNAIQLALGSFYPTLLLSGVIWPIEGMPVVLRYISLCL 757
            ::||              :|.|:...:.|.... ||.|:.|:|:.
Human  1151 FLIV--------------VIFSIVATDLNEYGF-LGLFFGTMLIP-------------------- 1180

  Fly   758 PLTLATSSLRSILTRGWAILESDV------YIG-------YVSTLSWIVGFLVLTLLVLR 804
            |.||.          |...:.|::      |:|       |::.|...:.||:. |.:||
Human  1181 PFTLI----------GSLFIFSEISPDSMDYLGASESEIVYLALLIPYLHFLIF-LFILR 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	71/245 (29%)
		ABC_DR_subfamily_A	74..286	CDD:213197	68/240 (28%)
		pip_yhgE_Nterm	427..>474	CDD:276270	10/47 (21%)
		ABC2_membrane_3	429..801	CDD:289468	71/419 (17%)
		ABC2_membrane	601..769	CDD:279410	28/176 (16%)
ABCA9	XP_024306297.1	ABC2_membrane_3	53..416	CDD:315386
ABCA9	XP_024306297.1	AAA	<245..1609	CDD:333001	177/905 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810