DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and abca1b

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	XP_005173137.1	Gene:	abca1b / 100136868	ZFINID:	ZDB-GENE-030131-9826	Length:	2282	Species:	Danio rerio

Alignment Length:	1090	Identity:	216/1090 - (19%)
Similarity:	354/1090 - (32%)	Gaps:	404/1090 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 ATNNDG--GTQPNAVAAWGAPANGPRNTQAAVSVRHAFKAY--GKKKNANQVLNNLNMTVPKGTI 105
            :|||..  |.:.||.|.  .....|.:.:..|.:.:..|.|  |||    ..::.|.:...:|.|
Zfish   873 STNNTAIHGKKSNAGAV--CIEEEPTHLKLGVYIENLVKVYRHGKK----LAVDGLTLGFHEGQI 931

  Fly   106 YGLLGASGCGKTTLLSCIVGRRYMDAGEIFVLGGKPGTRGSGVPGKRVGYMPQEIALYGEFSIQE 170
            ...||.:|.||||.:|.:.|.....:|..:::|....:..|.: .:.:|..||...|:...:::|
Zfish   932 TSFLGHNGAGKTTTMSILTGLFPPTSGTAYIMGKDIRSELSSI-RQSLGVCPQHNVLFSMLTVEE 995

  Fly   171 TMMYFGWIFGMDTKEILERLQFLLNFLDLP-SEKRLVKNLSGGQQRRVSFAVALMHDPELLILDE 234
            .:.::..:.|:..:|:...::.:|:...|| ..|.....||||.||::|.|:|.:...:::||||
Zfish   996 HIWFYARLKGLSEEEVKAEMEQILSDTGLPHKRKSRTSQLSGGMQRKLSVALAFVGGSKVVILDE 1060

  Fly   235 PTVGVDPLLRQSIWNHLVHITKAGQKTVIITTHYIEEAR-QAHTIGLMRSGHLLAEESPSVLLSI 298
            ||.||||..|:.||:.|:.. :|| :|::::||:::||. ....|.::..|.|
Zfish  1061 PTAGVDPYARRGIWDLLLKY-RAG-RTILLSTHHMDEADILGDRIAIISHGKL------------ 1111

  Fly   299 YKCISLEEVFLK-------------------LSRIQSQKGDVTHVNFSNNISLHAMAFGSKMDKP 344
              |.....:|||                   ||..::....|:.|...:|.|..:...|...|:
Zfish  1112 --CCVGSSLFLKTQLGTGYYLTLVKKNTEPSLSSCRNSSSTVSFVKKDDNASESSSDAGLGSDQ- 1173

  Fly   345 SSSQEGGVVGLNFHQSKEV-------------------LINDSNGSI-YTLNQEPYSPP------ 383
             .|:....:|.::.:|..|                   ::.|....| |.|   ||...
Zfish  1174 -ESEAATAIGTSWPESPVVPVDVTIISRLILKHVPAARMVEDQGHEITYVL---PYESAKNGAFV 1234

  Fly   384 ------------------------------------------------PSRRNN----------- 389
                                                            |.||..
Zfish  1235 ELFHDLDDRLADLGISSYGVSDTTLEEIFLKVAEDSGVDTEMLSDGTLPVRRQRRHAFGADHQSC 1299

  Fly   390 -NPNDEESCQDCYSN-----------LCKITSKGKIR------------ALLTKNMLRMWRNVGV 430
             .|..|:...||..:           |.....||..:            |||.|.:|...|:
Zfish  1300 LKPLTEDDSFDCNESEGDPESKETDYLSGSDGKGSYQVKGWSLKRQQFVALLWKRLLYARRS--- 1361

  Fly   431 MLFIFALPVMQVILFCLAI---------GR----------------------------------- 451
            ....||..|:..:..|:|:         |:
Zfish  1362 RKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLALNPWMYEEQFMFFSEDAPYDVSTHKLLRAL 1426

  Fly   452 -DPQGLNLAIVNGE--------MND----------------TVRENCYW---------EDGCHFK 482
             |..|.....:.||        |.|                |.|.   |         |..|:.|
Zfish  1427 FDDPGFGTRCMKGESIPDAPCTMGDEEWSTPEVPESIIEILTTRN---WTMNDPSPACECSCNGK 1488

  Fly   483 ----------------------------NLGCRYLSHLNTSVVKTY------------------- 500
                                        ||..|.:|..   :||||
Zfish  1489 KKMLPECPAGAGGLPPPQIKISETETLQNLTGRNISDY---LVKTYAQIIGKSLKNKIWVNEFRY 1550

  Fly   501 ---------------YEDLDDAKEAVRK----GTAWGAVYISENFTDAFIARANLGRDSDDETID 546
                           .|::|||...||:    |...|:.  ::.|..:..|..| |.|:
Zfish  1551 GGFSLGARSTQVLPPAEEIDDAISRVREIFQLGKDSGSA--ADRFLKSLSAFIN-GLDT------ 1606

  Fly   547 SSEVKVWLDMSN-QQIGVMLNRDIQLAFRDFAM--GLLGQCGSNPKLGDVPIQFRDPIYG-TMNP 607
            .:.||:|.:... ..||..||          .|  |:|   .:|...|..|.:|....|. .:|.
Zfish  1607 KNNVKIWFNNKGWHSIGAFLN----------VMNNGIL---RANLPPGKDPSEFGITAYNHPLNL 1658

  Fly   608 S---------FTDFVAPGVILTIVFFLAVALTSSA--LIIERTEGLLDRSWVAGVSPFEILFSHV 661
            :         .|..|...|.:.::|.::....|..  ||.||........:::||.|:....::.
Zfish  1659 TKEQLSQVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVNKAKHMQFISGVQPYLYWLANF 1723

  Fly   662 ITQFVVMCG----QTTLVLIFML----VVFGVTNNGDLFWVIVLTLLQG------MCGMCFGFLI 712
            :..   ||.    .|.::|||:.    .....||   |..:.:|.||.|      |....|.|.|
Zfish  1724 LWD---MCNYVVPATLVILIFVCFQQKAYVSATN---LPVLALLLLLYGWSITPLMYPASFLFKI 1782

  Fly   713 SSVCELERNAIQLALGSFYPTLLLSGVI----------WPIEGMPVVLRYISLCLP-LTLATSSL 766
            .|...:...::.:.:|       ::|.|          ..|.|:..:|:.:.|..| ..|....:
Zfish  1783 PSTAYVVLTSVNILIG-------INGSISTFVMELFGNHEIGGINDILKNVLLIFPHFCLGRGLI 1840

  Fly   767 RSILTRGWA-ILESDVYIGYVSTLSW-IVG------------FLVLTLLV 802
            ..:..:..| .||......:.|.|.| :||            |.::|:|:
Zfish  1841 DMVKNQAMADALERFGENRFRSPLEWDMVGKNLFAMAVEGVVFFIITVLI 1890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	65/220 (30%)
		ABC_DR_subfamily_A	74..286	CDD:213197	64/215 (30%)
		pip_yhgE_Nterm	427..>474	CDD:276270	14/115 (12%)
		ABC2_membrane_3	429..801	CDD:289468	104/569 (18%)
		ABC2_membrane	601..769	CDD:279410	41/204 (20%)
abca1b	XP_005173137.1	rim_protein	1..2242	CDD:130324	216/1090 (20%)
		ABC_subfamily_A	902..1121	CDD:213230	67/239 (28%)
		ABC_subfamily_A	1932..2152	CDD:213230
		DUF4162	2146..2238	CDD:290451
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900