DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9988 and F07C3.3

DIOPT Version :9

Sequence 1:	NP_651625.1	Gene:	CG9988 / 43388	FlyBaseID:	FBgn0039591	Length:	668	Species:	Drosophila melanogaster
Sequence 2:	NP_505391.4	Gene:	F07C3.3 / 184124	WormBaseID:	WBGene00017194	Length:	746	Species:	Caenorhabditis elegans

Alignment Length:	702	Identity:	165/702 - (23%)
Similarity:	288/702 - (41%)	Gaps:	174/702 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 QDVVRPAYFVE---SAKCKIPYVD--PFASDAMAIFHPEHFETCSN------------ETALVTP 106
            :|:: |.:..|   ..||::...|  ...|:.....|| ||.....            |..|..|
Worm   107 EDII-PFHLSERMRQLKCEVKQKDYATMDSEGYIYVHP-HFVDWPRLERDVQCKVDIIEGGLRKP 169

  Fly   107 IYDISRQRYVLFINESL-----ASIILNSNGGEYNCYYQEITRDRKHDSYDKMERKYFSQNYEVP 166
            ..::::..  :||.::|     ..:.:|::....|||           ::.|...|     .|||
Worm   170 ERNMTKNS--MFIKKTLEIPSNERLFVNADAFVINCY-----------NHSKKAVK-----PEVP 216

  Fly   167 LHVEGLILTCHRLGNESDILQ-SDAYNLIQYRPPPKGLSLKPSKRKP----SVLMFGIDSLSRIN 226
            :..:.......:...|.:||: .|.|:...|     |..::....|.    |:.:.|.||.:|..
Worm   217 IWKKPFPGMKDKNLPEDEILRVKDLYSYGDY-----GNKIREQVSKAVDRYSIDILGFDSTARTM 276

  Fly   227 LRRTMPKVYKFLTRDGWFEQQGYNKIGDNTFPNLLAILTGYNPESAIKKV---------CNW--- 279
            ..|.||:..:.:.:..:....||.|:.||:..||..||.| :.|.|:||.         .||
Worm   277 FMRHMPRTVEVMAKLDYHYLYGYTKVADNSMVNLAPILVG-DMEEALKKPKYDKSGDFNINWLLP 340

  Fly   280 HEDGCLDRTP--FIWHYFRNA-SYLTAYAED--EAGINTFNY----WKPGFLEQPTDFYLRPLQK 335
            .||. :|.|.  |:|...:.. ...:.:.||  ..|:..|||    ::|||.|.|.|.|.|....
Worm   341 TEDK-MDPTKLNFLWKIMKEKYGCESLFNEDISTKGLGLFNYPPTEFQPGFTENPADHYYRAYYL 404

  Fly   336 AIESGLNTWK---CSDCSMKYCIGRRITSSYAYDMARNFANRFVDERPI--WGLFWSNSFSHDSF 395
            |:   ...||   |.|       |.::.:.:. ::.|.||:|:   |.|  :|..:..:.:|::.
Worm   405 AV---YENWKYEACRD-------GEQLQNEFV-NIWRRFAHRY---RNICHFGFTFVTTLTHEAG 455

  Fly   396 QMPSKMEDYVLQYLLDFEADGVFDQSIMVFLSDHGSRYGRLMSLPSGFLEERLPSMFIYLPPWFR 460
            .:...:::.:..:|.....:|..|.::.:.:.|||:|.|.:.|..:|.:|||:|.|.:..|..|.
Worm   456 LVLEILDEKLAAHLSQMHLNGDLDNTLSIIMGDHGNRIGAIKSRYTGRIEERMPLMAMRFPTGFA 520

  Fly   461 AQYP-EYARALELNRNRLTSNYDLHNTLKHIIEL------GGTPDGQTLPKAADCPKCQSLFYPV 518
            ..|| ||...|: |:::||||:|:|.||..|:.:      ..:.:|:.:          |||..:
Worm   521 ETYPVEYKNFLD-NKHKLTSNFDVHKTLHDIVHMRLGDNKAKSDEGRGI----------SLFDAI 574

  Fly   519 DETRSCEDAGIPEHFCTCV--------PY----------KRLD-----TQWAKS--------IAP 552
            ..||:|.|..:||:||.|:        |.          :::|     ..|.|:        ::.
Worm   575 PNTRTCADVIVPENFCMCMIDVSSIANPLPNFNKKKPTDQKMDQFNTLKSWLKTENLDDCVDVSS 639

  Fly   553 KVIGRINEYLAGRNLSKICSELTLSYIHLTEMKVELDQ--------NFHDDVPRAELGTY----- 604
            ...|:..:.:|...||:. ...|.:...:.|:..|.::        ||...|.    |||
Worm   640 LETGQTFQEMAINPLSRF-GLRTKNNASMLELMKERNKKNPELNYINFEFSVS----GTYKNGEP 699

  Fly   605 -----RTMFKVKQNSADFRATVIFNNVTDSVEVEVPTISRLDSYENVSTCVK 651
                 ||...|:::::.    :||..:..    |:|...|..|..:|..|::
Worm   700 LSMLVRTELFVEKSTSQ----LIFEPMIQ----EMPASCRFVSIFDVCQCLR 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9988	NP_651625.1	DUF229	90..580	CDD:281053	139/575 (24%)
CG9988	NP_651625.1	ALP_like	212..493	CDD:293745	90/311 (29%)
F07C3.3	NP_505391.4	DUF229	75..623	CDD:308570	139/567 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165299
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JJT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740