DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10011 and Ankrd50

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	NP_001360823.1	Gene:	Ankrd50 / 99696	MGIID:	2139777	Length:	1427	Species:	Mus musculus

Alignment Length:	1418	Identity:	536/1418 - (37%)
Similarity:	774/1418 - (54%)	Gaps:	246/1418 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   718 CRTIIADGYYELLLSNPEILECLSVDNIEKNPDECFKKAFLFPLLELTPPKTALLLLIDSIDEN- 781
            |::.:..| ||..|.:|.:...|.....|:||.|.||:..|.|||.:.||..:|.||:||:||.
Mouse   135 CQSGLLQG-YEDKLRDPAVQSLLEPGECERNPAEAFKRCVLLPLLGMKPPPQSLYLLVDSVDEGC 198

  Fly   782 YINEGNLISTLKGGRGTVTNHKSRNVAELLSNHIHLFPKWLFLVCTTKKQTKQITKMFTGFKKIT 846
            .:.||...|....|          .|||||:.|...||.||.|:|:.:||::.:||||:||:||:
Mouse   199 NVVEGEQTSPSLSG----------TVAELLAGHHEFFPPWLLLLCSARKQSRAVTKMFSGFRKIS 253

  Fly   847 LDDLRKSHVVKDVQEYIINRLNSDFKDSIMLTKEIIESLHQLYIKSNGCILYLEKVLHGIKDNFF 911
            ||||||:::|||||:||::||:.:......||||..|:|:||:|||:||.||||:||.|:.:||.
Mouse   254 LDDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAETLNQLHIKSSGCFLYLERVLDGVVENFI 318

  Fly   912 SFREIKLIPCTLNGLYLYICQKSFNKKQYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNYTIDCQ 976
            ..|||:.||.|||||||::||:.|.:||:.|::|:|||:||:...:....|::.:.|.|.::..:
Mouse   319 MLREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAACRPLTMTELYHAVWTKNMSLTLE 383

  Fly   977 EFEKRLQLMRNILAYDSNAQRLKIFHNSFADWLVDVKFATKKFICDVNEGHVMISMYYLLVADTL 1041
            :|:::|.::..:|.....:.:: :||:|||:||:|||..|:|::|:..|||.|::|.|...|..|
Mouse   384 DFQRKLDVLSKLLVDGLGSTKI-LFHHSFAEWLLDVKHCTQKYLCNAAEGHRMLAMSYTCQARNL 447

  Fly  1042 CANTVRRFAYHLIRSGEYLTSRHVDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFL 1106
            .....:.||.|||.|...|.    ..:|.|.::.:...:.|...|
Mouse   448 TPLEAQEFALHLINSNLQLE----PAELALWMIWNGTPVKDSLST-------------------- 488

  Fly  1107 PKTRAMLERFLASELSEPFAQFLCDFFKPSLPTDAKMLKLLIETG--INNAESQNSCESSLMSPE 1169
                                         .:|.:.::|:|||..|  :|:.:...||    :..:
Mouse   489 -----------------------------LIPKEQEVLQLLIRAGAHVNSEDDHTSC----IVRQ 520

  Fly  1170 LSEKSQNIDFELADLLL---SSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHIE 1231
            ..|:..:|     ..||   :|...|                     |.|..:.|...:.|..::
Mouse   521 ALEREDSI-----RTLLDNGASVNQC---------------------DSNGRTLLANAAYSGSLD 559

  Fly  1232 LHKGKALIHILANDGNHQLLERALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQP 1296
                  ::::|.:.|               .||||||.:|.|.|.:|||.||.:||..|:
Mouse   560 ------VVNLLVSRG---------------ADLEIEDAHGHTPLTLAARQGHTKVVNCLI----- 598

  Fly  1297 CNDGTGRMKRVDVNHADRDGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSG 1361
               |.|    .::||.|:||||.||||:||||:|||..|: ....|:|.||.:.|||||||||.|
Mouse   599 ---GCG----ANINHTDQDGWTALRSAAWGGHTEVVSALL-YAGVKVDCADADSRTALRAAAWGG 655

  Fly  1362 HEDILKLLIESGADVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLDGRSALCVAALC 1426
            ||||:..|::.||:||..|.:|||:||||:||||.:|||.||::||.|||.|:|||:||.|||||
Mouse   656 HEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC 720

  Fly  1427 --GSSGYSKVISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPL 1489
              .|.|::.|:|.|:|.||..|..|.|||:||||:::||:.:|.:||||..||.|..|..|||||
Mouse   721 VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPL 785

  Fly  1490 WAACTAGHATVVKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTP 1554
            .||.:.|||:||..|||||..:|.:||||||||||.:||||||.||.||||||||:|||:|||||
Mouse   786 LAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDESHRDDAGWTP 850

  Fly  1555 LHYAAFEGFHEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGK 1619
            ||.|||||...:|..|:|.||:.:|.||:|:....||:|||...|||.||: :.|.:||:.:||:
Mouse   851 LHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE-NKSNIDQRGYDGR 914

  Fly  1620 TAFRLACLEGHMDTVEFLLKFCCDVNSKDADSRTTLYILALENKLEIVKYLLDMTNVDVNIPDSE 1684
            .|.|:|.||||.|.||.|.....|||.||||.|.|||||||||:|.:.:|.|: ...:|...|:|
Mouse   915 NALRVAALEGHRDIVELLFSHGADVNYKDADGRPTLYILALENQLTMAEYFLE-NGANVEASDAE 978

  Fly  1685 GRTALHVAAWQGHADMVKTLIEAGADVNSMDLEARTPLHSCAWQGNHDVMNILLYYGALADHACK 1749
            |||||||:.||||.:||:.||...||||:.|.|.|:.|.|.||||:..|:.:|:.:||:.||.|.
Mouse   979 GRTALHVSCWQGHVEMVRVLIACHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCN 1043

  Fly  1750 QGATALGISAQEGHEKCVIALLQFGANPYKSDHCGRTPIKLAAKSSRTSILKIFESYTKNEASNP 1814
            ||||||.|:|||||...|..||:.||:|..:|..|||.:::|||:..:.|:|:.|.|..:..:..
Mouse  1044 QGATALCIAAQEGHVDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGC 1108

  Fly  1815 NEPKFHAHASMLRSPDQP-----PALPLHQN---------LAPY-------PAHASASSVCSAAT 1858
            :....|   :|.:.|.|.     .:|.:..|         |.|.       ||||.:|...|..:
Mouse  1109 SPSPVH---TMEQKPPQSAPSKMQSLTIRSNSSGGTGGGDLQPSLRGLPNGPAHAFSSPSESPDS 1170

  Fly  1859 T-----ATVHNGSHLHVLNASSSTHSSN--------------NFYQNTMQSDTSSLHKRKSVIS- 1903
            |     :::.|.|.....|:|..|.||.              :|.:...|........|:||:|
Mouse  1171 TVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHSLSFTEQIQQHSLPRSRSRQSVVSP 1235

  Fly  1904 ---SQSTGSSNDQAPLTFTQQLQRQSKLSSRNNLMVNSKHASSSGAAGHKSSGGGGGAQRHSQVL 1965
               :||.|.|::.....|.....:.|..|:::|....|.::|.||:||.|       |:::|...
Mouse  1236 SSTTQSLGHSHNSPSSEFEWSQVKPSLKSTKSNKGGKSDNSSKSGSAGKK-------AKQNSSSQ 1293

  Fly  1966 PDLSEHQLASNMTNEADMYDMECMSPLYATPPHSPSSELSSPGQLPGLNAFVDDERAGTSSGGGA 2030
            |.:.|:::..                                          .|:|...:..|.:
Mouse  1294 PKVLEYEMTQ------------------------------------------FDKRGPVAKSGSS 1316

  Fly  2031 KLPDNHFARDTHMRIILGNLKEN---QP------SSSGKSKRSGVSSNPAMRL 2074
              |......::..:|::.:.:::   ||      .||.:.:|:|:.:||...|
Mouse  1317 --PPKQTPAESQCKIVVPSSQDSSRAQPQFLIHQQSSEQKRRNGIMTNPNYHL 1367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728	52/113 (46%)
		Ank_4	1237..1291	CDD:290365	18/53 (34%)
		ANK	1266..1403	CDD:238125	73/136 (54%)
		ANK repeat	1270..1313	CDD:293786	15/42 (36%)
		Ank_2	1275..1380	CDD:289560	53/104 (51%)
		ANK repeat	1315..1347	CDD:293786	18/31 (58%)
		ANK repeat	1349..1380	CDD:293786	19/30 (63%)
		Ank_2	1354..1449	CDD:289560	58/96 (60%)
		ANK repeat	1382..1413	CDD:293786	21/30 (70%)
		ANK	1410..1538	CDD:238125	77/129 (60%)
		ANK repeat	1415..1446	CDD:293786	18/32 (56%)
		Ank_5	1438..1489	CDD:290568	27/50 (54%)
		ANK	1479..1604	CDD:238125	78/124 (63%)
		ANK repeat	1484..1515	CDD:293786	18/30 (60%)
		Ank_2	1489..1581	CDD:289560	61/91 (67%)
		ANK repeat	1517..1548	CDD:293786	25/30 (83%)
		ANK repeat	1550..1581	CDD:293786	18/30 (60%)
		Ank_2	1555..1648	CDD:289560	45/92 (49%)
		ANK	1578..1705	CDD:238125	66/126 (52%)
		ANK repeat	1617..1648	CDD:293786	16/30 (53%)
		Ank_2	1624..1715	CDD:289560	51/90 (57%)
		ANK	1645..1771	CDD:238125	69/125 (55%)
		ANK repeat	1650..1682	CDD:293786	15/31 (48%)
		ANK repeat	1684..1715	CDD:293786	20/30 (67%)
		Ank_2	1689..1781	CDD:289560	49/91 (54%)
		ANK repeat	1717..1742	CDD:293786	10/24 (42%)
		ANK repeat	1750..1775	CDD:293786	15/24 (63%)
Ankrd50	NP_001360823.1	AAA_16	23..195	CDD:379062	24/60 (40%)
		Cas9_REC	<251..>352	CDD:391787	57/100 (57%)
		PHA03095	480..>717	CDD:222980	112/349 (32%)
		ANK repeat	544..575	CDD:293786	9/51 (18%)
		ANK repeat	577..608	CDD:293786	15/42 (36%)
		ANK repeat	610..641	CDD:293786	18/31 (58%)
		PHA03095	625..>907	CDD:222980	167/283 (59%)
		ANK repeat	643..674	CDD:293786	19/30 (63%)
		ANK repeat	676..707	CDD:293786	21/30 (70%)
		ANK repeat	709..745	CDD:293786	19/35 (54%)
		ANK repeat	747..778	CDD:293786	17/30 (57%)
		PHA02876	<763..>1102	CDD:165207	190/340 (56%)
		ANK repeat	780..811	CDD:293786	18/30 (60%)
		ANK repeat	813..844	CDD:293786	25/30 (83%)
		ANK repeat	847..877	CDD:293786	17/29 (59%)
		ANK repeat	879..910	CDD:293786	14/31 (45%)
		ANK repeat	912..943	CDD:293786	16/30 (53%)
		ANK repeat	945..976	CDD:293786	15/31 (48%)
		ANK repeat	978..1009	CDD:293786	20/30 (67%)
		ANK repeat	1011..1042	CDD:293786	14/30 (47%)
		ANK repeat	1044..1075	CDD:293786	18/30 (60%)
		ANK repeat	1077..1102	CDD:293786	10/24 (42%)
		THRAP3_BCLAF1	1225..>1339	CDD:373846	28/164 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849267
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BFJC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004643
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4356
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730