DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10011 and AVO2

DIOPT Version :9

Sequence 1:NP_651624.2 Gene:CG10011 / 43387 FlyBaseID:FBgn0039590 Length:2119 Species:Drosophila melanogaster
Sequence 2:NP_013784.1 Gene:AVO2 / 855090 SGDID:S000004672 Length:426 Species:Saccharomyces cerevisiae


Alignment Length:578 Identity:118/578 - (20%)
Similarity:203/578 - (35%) Gaps:185/578 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1528 QGNVETVRQLLDRGLD-ETHRDNA-GWTPLHYAAFEGFHEVCLQLLESGAKIDECDNEGKTALHL 1590
            :||:..|::||.|..| .|:.|:. ||:.||||::.|.:.:|:.|::.|                
Yeast    15 EGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLG---------------- 63

  Fly  1591 AAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACLEGHMDTVEFLLKFCCDVNSKDADSRTTL 1655
                   |....|:         |...|.|...||.::||..|:..||:                
Yeast    64 -------HDKHELI---------KTFKGNTCVHLALMKGHEQTLHLLLQ---------------- 96

  Fly  1656 YILALENKLEIVKYLLDMTNVDVNIPDSEGRTALHVAAWQGHADMVKTLIEAGADVNSMDLEART 1720
                     :..::        :|.....||..:|:|....:...:..||..|||:..||....|
Yeast    97 ---------QFPRF--------INHRGENGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDT 144

  Fly  1721 PLHSCAWQGNHDVMNILLYYGALADHACKQGATALGISAQE-GHEKCVIALLQFGANPYKSDHCG 1784
            |||.|...|:...|.:||          .:|..:|..:.:: |:.|                   
Yeast   145 PLHVCLEYGSISCMKMLL----------NEGEVSLDDNVRDKGNWK------------------- 180

  Fly  1785 RTPIKLAAKSSRTSIL-KIFESYTK--------NEASNPNEPKFHAHASMLRSPDQPPALPLHQN 1840
              ||.:|......:|. |:.:...|        .:.|:...|..:|.|:....|.  |.|.::  
Yeast   181 --PIDVAQTFEVGNIYSKVLKEVKKKGPPLGAGKKPSSFRTPILNAKATFEDGPS--PVLSMN-- 239

  Fly  1841 LAPYPAHASASSVCSAATTATVHNGSHLHVLNASSSTHSSNNFYQNTMQSDTSSL-HKRKSVISS 1904
             :||..::               |.|.|.||....|||:::....|...|.|:.: :.||..:|:
Yeast   240 -SPYSLYS---------------NNSPLPVLPRRISTHTTSGNGGNRRSSITNPVFNPRKPTLST 288

  Fly  1905 QS-TGSSNDQAPLTFTQQLQRQSKLSSRNNLMVNSKHASSSGAAGHKSSGGGGGAQRHSQVLPDL 1968
            .| :.|||..:.|       |.:.::.:..:.|:.|....|.:..|.::    ....|:.:.  |
Yeast   289 DSFSSSSNSSSRL-------RVNSINVKTPVGVSPKKELVSESVRHSAT----PTSPHNNIA--L 340

  Fly  1969 SEHQLASNMTNEADMYDMECMSPLYATPPHSPSSELSSPGQLPGLNAFVDDERAGTSSGGGAKLP 2033
            ....|..|.:|:....|.:                          .|.::|: .|..:||.|   
Yeast   341 INRYLLPNKSNDNVRGDSQ--------------------------TATINDD-GGGGNGGDA--- 375

  Fly  2034 DNHFARDTHMRIILGNLKENQPSSSGKSKRSGVSSNPAMRLIRSRFDAASQLIRRTNN 2091
                      .|.:|..|:....:..|.|....:..|..|:  |..:.....:|.:||
Yeast   376 ----------TIGMGLRKDPDDENENKYKIKVNNGEPRRRV--SLLNIPISKLRNSNN 421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10011NP_651624.2 AAA 344..457 CDD:214640
Methylase_S <772..885 CDD:279728
Ank_4 1237..1291 CDD:290365
ANK 1266..1403 CDD:238125
ANK repeat 1270..1313 CDD:293786
Ank_2 1275..1380 CDD:289560
ANK repeat 1315..1347 CDD:293786
ANK repeat 1349..1380 CDD:293786
Ank_2 1354..1449 CDD:289560
ANK repeat 1382..1413 CDD:293786
ANK 1410..1538 CDD:238125 3/9 (33%)
ANK repeat 1415..1446 CDD:293786
Ank_5 1438..1489 CDD:290568
ANK 1479..1604 CDD:238125 20/77 (26%)
ANK repeat 1484..1515 CDD:293786
Ank_2 1489..1581 CDD:289560 19/54 (35%)
ANK repeat 1517..1548 CDD:293786 8/20 (40%)
ANK repeat 1550..1581 CDD:293786 10/31 (32%)
Ank_2 1555..1648 CDD:289560 20/92 (22%)
ANK 1578..1705 CDD:238125 17/126 (13%)
ANK repeat 1617..1648 CDD:293786 9/30 (30%)
Ank_2 1624..1715 CDD:289560 17/90 (19%)
ANK 1645..1771 CDD:238125 25/126 (20%)
ANK repeat 1650..1682 CDD:293786 1/31 (3%)
ANK repeat 1684..1715 CDD:293786 9/30 (30%)
Ank_2 1689..1781 CDD:289560 22/92 (24%)
ANK repeat 1717..1742 CDD:293786 9/24 (38%)
ANK repeat 1750..1775 CDD:293786 4/25 (16%)
AVO2NP_013784.1 Ank_4 9..60 CDD:372654 17/44 (39%)
ANK repeat 9..37 CDD:293786 8/21 (38%)
ANKYR 37..>185 CDD:223738 49/243 (20%)
ANK repeat 39..72 CDD:293786 12/64 (19%)
ANK repeat 75..106 CDD:293786 10/63 (16%)
ANK repeat 108..139 CDD:293786 9/30 (30%)
ANK repeat 141..165 CDD:293786 9/33 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3509
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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