Protein Alignment CG10011 and TANC1

DIOPT Version :10

• Sequence 1: NP_651624.2
• Gene: CG10011 / 43387
• FlyBaseID: FBgn0039590
• Length: 2119
• Species: Drosophila melanogaster
• Sequence 2: XP_047302063.1
• Gene: TANC1 / 85461
• HGNCID: 29364
• Length: 1889
• Species: Homo sapiens
• Alignment Length: 2014
• Identity: 413/2014 - (20%)
• Similarity: 673/2014 - (33%)
• Gaps: 645/2014 - (32%)

  Fly   431 EAQQQEFKLDEAMNNISLSENAEELL------------------IEE--------LKRGASECDT 469
            |..:.|.|.|   |..|.|..|:|||                  ||:        |.:|.|.|.|
Human   145 EPDEHEAKAD---NEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCST 206

  Fly   470 -------KELDNFQSQRTSTVNKAA--RTTLTRQQSEPAPLQAMD---------AVNSDEKTGSN 516
                   ...|:..|...|.|:|.|  ::......|..:.|::.|         :..:|:::||:
Human   207 LTSSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRSGSS 271

  Fly   517 --YGTHPPKRASRERG---DTEQDKDMGSEKEQKQSQEPKETPKSSPAKSKSKIPVKRGRSGSGV 576
              :......|...::|   |...|......:|:.........||:..:.....:|..:|.|...:
Human   272 LEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYSQGSSSLIM 336

  Fly   577 LSPSKL-ATISNGGQSIQQGGGEDIADLNTD----------QEKHEIEA----------AIKDDK 620
            ..|:.: ||.|...:.:....|:..|.|.|.          ....|::|          .:|...
Human   337 PRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAGGRAQEVKARFAPYKPQDILLKPLL 401

  Fly   621 VEEPQANNEDKKEDKPEADKELNDQLKE-ELDK-------------------------------- 652
            .|.|....:.....:.....::.:.|:. ||.:
Human   402 FEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGKTAIISKLVALSCHGSRMR 466

  Fly   653 --SSQEPKEEETKEEATADSSAEPLIDFTES-NVNGKQEEPQLKPPVPGEKPR------------ 702
              :|..|.......:.|.|....||:..:.| :.:...:.|........::||
Human   467 QIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPLGSISAENQRPREDAVKYLASKVV 531

  Fly   703 -----ISTNTLPPPLPK------TKSCRTIIADGYYELLLSNPEILECLSVDNIEKNPDECFKKA 756
                 .:.||....:|:      ...||:.....|.:||:..|::...||:.:..::|...||:.
Human   532 AYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIKEPQLQSMLSLRSCVQDPVAAFKRG 596

  Fly   757 FLFPLLELTP----PKTALLLLIDSIDENYINEGNLISTLKGGRGTVTNHKSRNVAELLSNHIHL 817
            .|.||..|..    |:...::|||.::|...::.:...||           |..:.:::|.
Human   597 VLEPLTNLRNEQKIPEEEYIILIDGLNEAEFHKPDYGDTL-----------SSFITKIISK---- 646

  Fly   818 FPKWLFLVCTTKKQTKQITKMFTGFKKITLDDL-RKSHVVKDVQEYIINRLNS--DFKDSIMLTK 879
            ||.||.|:.|.:...::|..... |.|::|||. ....:..|:..|:.:|::|  |...:|.|..
Human   647 FPAWLKLIVTVRANFQEIISALP-FVKLSLDDFPDNKDIHSDLHAYVQHRVHSSQDILSNISLNG 710

  Fly   880 EIIESL-----HQLYIKSNGCILYLEKVLHGIKDNFFSFR--EIKLIPCTLNGLYLYICQKSF-N 936
            :...:|     ..|.::|.|..|||:..|...:......:  ..|::|.:|:.|||..|...| .
Human   711 KADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYKVVPVSLSELYLLQCNMKFMT 775

  Fly   937 KKQYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNYTID--CQEFEKRLQLMRNILAYDSNAQRLK 999
            :..:.:..|:|||.|||...:....:|..:...:...:  .::|::|:..:...|....:..|:
Human   776 QSAFERALPILNVALASLHPMTDEQIFQAINAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRM- 839

  Fly  1000 IFHNSFADWLV-DVKFATKKFICDVNEGHVMISMYYLLVADTLCANTVRRFAYHLIRSGEYLTSR 1063
            ..|.||.:||| ........|:|:...||.:::..:......|.........:|::::
Human   840 FCHPSFREWLVWRADGENTAFLCEPRNGHALLAFMFSRQEGKLNRQQTMELGHHILKA------- 897

  Fly  1064 HVDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFLPKT-------RAMLERFLASEL 1121
                                             |.||   ....||       :|:...:....|
Human   898 ---------------------------------HIFK---GLSKKTGISSSHLQALWIGYSTEGL 926

  Fly  1122 SEPFAQFLCDFFKPSLPTDAKMLKLLIETGINNAESQNSCESSLMSPELSEKSQNIDFELADLLL 1186
            |...|. |.:.:.|::    |:.:|||..|.|
Human   927 SAALAS-LRNLYTPNV----KVSRLLILGGAN--------------------------------- 953

  Fly  1187 SSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHIELHKGKALIHILANDGNHQLL 1251
                                                                             
Human   954 ----------------------------------------------------------------- 953

  Fly  1252 ERALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPCNDGTGRMKRVDVNHADRDG 1316
                      ::...|..|....|.:.:..||.|||.|||.|. .|.|||           ..:|
Human   954 ----------VNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFG-ACLDGT-----------SENG 996

  Fly  1317 WTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLI----ESGADVN 1377
            .|.|..|:..||.::| .|:.:...::|..||:|:.||..:|..||.|||:.|:    ..|....
Human   997 MTALCYAAAAGHMKLV-CLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQP 1060

  Fly  1378 SVDRQG---RTSLIAASYMGHYDIVEILL----ENGANVNHLD-LDGRSALCVAALCGSSGYSKV 1434
            ...|:.   :.:|.||:.|||..:|:.||    |:...||..| |.|.:||..||   ..|..:|
Human  1061 GTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAA---GRGKLEV 1122

  Fly  1435 ISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACTAGHAT 1499
            ...||.|||...:.:..|:.||..::.:|:.::..||||...|.:|:|..|||||..|...||.:
Human  1123 CELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLS 1187

  Fly  1500 VVKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRG--LDETHRDNAGWTPLHYAAFEG 1562
            .|:.||..|..:..:|.||.:.||....:|:...|:.|::.|  :|:|  |..|.|||..|||.|
Human  1188 TVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQT--DKNGRTPLDLAAFYG 1250

  Fly  1563 FHEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACL 1627
            ..|..|.|:|.||.|:..|:.|...|..|........|.|||       .:.|..|..|:.:|
Human  1251 DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALL-------RKGAKLGNAAWAMA-- 1306

  Fly  1628 EGHMDTVEFLLKFCCDVNS--------KDADSRTTLYILALE--------------NKLEIVKYL 1670
            ....|.:..||:...:..:        |:|..|   |..||.              |:|.:..||
Human  1307 TSKPDILIILLQKLMEEGNVMYKKGKMKEAAQR---YQYALRKFPREGFGEDMRPFNELRVSLYL 1368

  Fly  1671 -----LDMTNVDVNIPDSEGRTALHVAAWQGHADMVKTLIEAGADVNS-------MDLEARTPLH 1723
                 ...|| |..:.:.....||.:......|...:    |.|..||       .||:....|
Human  1369 NLSRCRRKTN-DFGMAEEFASKALELKPKSYEAFYAR----ARAKRNSRQFVAALADLQEAVKL- 1427

  Fly  1724 SCAWQGNHDVMNILLYYGALADHACKQGATALGISAQEGHEKCVIALLQFGAN------PYKSDH 1782
             |  ..|.:|..:|    |..:..|||    |..|.|:..:..:.|.|....|      |..|||
Human  1428 -C--PTNQEVKRLL----ARVEEECKQ----LQRSQQQKQQGPLPAPLNDSENEEDTPTPGLSDH 1481

  Fly  1783 -----------------CGRTPIKLAAKSSRTSILKIFESYTKNEASNPNEPKFHAH-ASMLRSP 1829
                             ...||....:.|..:|.::..:...::: ..|..|:..|. ...||.|
Human  1482 FHSEETEEEETSPQEESVSPTPRSQPSSSVPSSYIRNLQEGLQSK-GRPVSPQSRAGIGKSLREP 1545

  Fly  1830 -----------------------------------------DQPPALPLHQNLAPYPA------- 1846
                                                     ..||..|:...:|..||
Human  1546 VAQPGLLLQPSKQAQIVKTSQHLGSGQSAVRNGSMKVQISSQNPPPSPMPGRIAATPAGSRTQHL 1610

  Fly  1847 --------------------------------------------------HASAS---------- 1851
                                                              |:|.:
Human  1611 EGTGTFTTRAGCGHFGDRLGPSQNVRLQCGENGPAHPLPSKTKTTERLLSHSSVAVDAAPPNQGG 1675

  Fly  1852 -SVCS-----AATTATVHNGSHLHVLNASSSTH---SSNNFYQNTMQSDTSSLHKRKSVISSQST 1907
             :.||     |:.|::..:||....:..||||.   ||::|..........:..|.|.|...||.
Human  1676 LATCSDVRHPASLTSSGSSGSPSSSIKMSSSTSSLTSSSSFSDGFKVQGPDTRIKDKVVTHVQSG 1740

  Fly  1908 GSSNDQAPLTF------TQQLQRQSKLSSRN-------NLMVNSKHASSSGAAGHKSSG------ 1953
            .:.:......|      |.:.|:||...||:       .|:.|     :|.|||.:|:.
Human  1741 TAEHRPRNTPFMGIMDKTARFQQQSNPPSRSWHCPAPEGLLTN-----TSSAAGLQSANTEKPSL 1800

  Fly  1954 ---GGGGAQRHSQVLPDLSEHQLASNMTNEADMYDME---CMSPLYA-------TPPHSPSSELS 2005
               ||...|..:     .|...|::::.|.|.:.::|   |..|:::       |..|.....:|
Human  1801 MQVGGYNNQAKT-----CSVSTLSASVHNGAQVKELEESKCQIPVHSQENRITKTVSHLYQESIS 1860

  Fly  2006 SPGQLPGLNAFVDDERAGTSSGGGAKLPDNHFARDTHMRIILGNLKENQPSSSGKSKRSGVSSN 2069
            .  |.|                        |.:.:.|...:          ::.|.|||.:.||
Human  1861 K--QQP------------------------HISNEAHRSHL----------TAAKPKRSFIESN 1888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	ANKYR	1236..1489	CDD:440430	79/264 (30%)
		ANK repeat	1270..1313	CDD:293786	15/42 (36%)
		ANK repeat	1315..1347	CDD:293786	9/31 (29%)
		ANK repeat	1349..1380	CDD:293786	11/34 (32%)
		ANK repeat	1382..1413	CDD:293786	12/37 (32%)
		ANK repeat	1415..1446	CDD:293786	12/30 (40%)
		ANKYR	1469..1788	CDD:440430	103/377 (27%)
		ANK repeat	1484..1515	CDD:293786	12/30 (40%)
		ANK repeat	1517..1548	CDD:293786	10/32 (31%)
		ANK repeat	1550..1581	CDD:293786	15/30 (50%)
		ANK repeat	1617..1648	CDD:293786	6/38 (16%)
		ANK repeat	1650..1682	CDD:293786	11/50 (22%)
		ANK repeat	1684..1715	CDD:293786	7/37 (19%)
		ANK repeat	1717..1742	CDD:293786	5/24 (21%)
		ANK repeat	1750..1775	CDD:293786	6/24 (25%)
TANC1	XP_047302063.1	PHA03307	37..>271	CDD:223039	29/128 (23%)
		NACHT	<549..>850	CDD:444362	75/317 (24%)
		ANK repeat	967..993	CDD:293786	14/37 (38%)
		PHA03100	976..>1233	CDD:476869	92/272 (34%)
		ANK repeat	995..1026	CDD:293786	9/31 (29%)
		ANKYR	1107..1313	CDD:440430	75/219 (34%)
		ANK repeat	1107..1137	CDD:293786	12/32 (38%)
		ANK repeat	1143..1170	CDD:293786	9/26 (35%)
		ANK repeat	1173..1203	CDD:293786	12/29 (41%)
		ANK repeat	1205..1236	CDD:293786	10/32 (31%)
		ANK repeat	1238..1269	CDD:293786	15/30 (50%)
		ANK repeat	1271..1296	CDD:293786	7/31 (23%)
		Spy	1301..>1438	CDD:443119	31/150 (21%)
		TPR repeat	1320..1345	CDD:276809	5/27 (19%)
		TPR repeat	1363..1393	CDD:276809	7/30 (23%)
		TPR repeat	1398..1426	CDD:276809	7/31 (23%)