DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10011 and PHO81

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	NP_011749.3	Gene:	PHO81 / 853148	SGDID:	S000003465	Length:	1178	Species:	Saccharomyces cerevisiae

Alignment Length:	1068	Identity:	202/1068 - (18%)
Similarity:	324/1068 - (30%)	Gaps:	398/1068 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1066 DLDLILML----------------------LESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFLP- 1107
            ||||.|.|                      ||..|...:.:|..:       |.|.:...|.|.
Yeast    44 DLDLHLTLDDIDEKIIHQRLQENKAAFFFKLERELEKVNGYYLAR-------ESDLRIKFNILHS 101

  Fly  1108 -----KTRAMLERFLASELSEPFAQFLCDFFKPSLPTDAKMLKLLIE---TGINNAESQNSCESS 1164
                 |....|....|:.....:|.|      .....|.:.|:..:|   ||.:.|
Yeast   102 KYKDYKINGKLNSNQATSFKNLYAAF------KKFQKDLRNLEQYVELNKTGFSKA--------- 151

  Fly  1165 LMSPELSEKSQNIDFELADLLLSSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHH 1229
            |...:...:|.:.||.||.::             :..|....:.|.:..||    |||.|.:.:.
Yeast   152 LKKWDKRSQSHDKDFYLATVV-------------SIQPIFTRDGPLKLNDE----TLHILLELND 199

  Fly  1230 IELHKGKALIH--ILAND----------------------------------GNHQL-------- 1250
            |:.:..:|.|.  ...||                                  .|::|
Yeast   200 IDNNNRRADIQSSTFTNDDDDDNNTSNNNKHNNNNNNNNNNNNNNNNNNILHNNYELTTSKISEN 264

  Fly  1251 -LERALNACKSPIDLEIEDYNG-QTALNIA----------------------------ARNGHLE 1285
             ||....|..|.:|:|:|..|. :..||||                            :.:.|..
Yeast   265 QLEHLFQASSSSLDMEMEIENWYKEILNIATVKDVQRKHALLRNFRETKIFTYLLQNSSESFHKN 329

  Fly  1286 VVKL---------LLSFSQPCNDGT------GRMKRVDVNHADRDGWTPLR------SASWGGHS 1329
            |..|         ||..:.|.:|.:      .....:|:::.|.|.....|      :||.   .
Yeast   330 VFSLLKECLTTLFLLLVASPLDDNSLHIFYKSNQDHIDLSYCDEDDQVFSRKNVFHEAASC---P 391

  Fly  1330 EVVRLLIAQPACKIDLADKE------------GRTALRAAAWSG-----HEDILKLLIESGADVN 1377
            |..||.|...|.......||            .|..|..||..|     |..::..|:|   ||:
Yeast   392 EKSRLFILDEALTTSKLSKETVQKLLNAQDIHSRVPLHYAAELGKLEFVHSLLITNLLE---DVD 453

  Fly  1378 SVDRQGRTSLIAASYMGHYDIV-EILLENGANVNHLDLDGRSALCVAALCGSSGYSKVISTLLDH 1441
            .:|...:|.|:.|....|.|:| ::|...|||.                      |.:...:||:
Yeast   454 PIDSDSKTPLVLAITNNHIDVVRDLLTIGGANA----------------------SPIEKPILDY 496

  Fly  1442 GANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRT------PLWAACTAGHATV 1500
            ..|..........||.|:....|.:..:||||..:..:..:...::      ||:...:.|..|:
Yeast   497 SKNVISSTKVQFDPLNVACKFNNHDAAKLLLEIRSKQNADNAKNKSSQHLCQPLFKKNSTGLCTL 561

  Fly  1501 VKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAG-WTPLHYAAFEGFH 1564
                              ..|..||   |:.:.::.|:..|.|....|... |||:.||...|..
Yeast   562 ------------------HIVAKIG---GDPQLIQLLIRYGADPNEIDGFNKWTPIFYAVRSGHS 605

  Fly  1565 EVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALL------------DIHSSFVDQKAHD 1617
            ||..:||:..|::|..|:.|.:.|..|..|..:..:.|||            :|:|....|:
Yeast   606 EVITELLKHNARLDIEDDNGHSPLFYALWESHVDVLNALLQRPLNLPSAPLNEINSQSSTQR--- 667

  Fly  1618 GKTAFRLACLEGHMDTVEFLL---KFCCDVNSKDAD------------------SRTTLYILALE 1661
                         ::|::...   ||..|:.....|                  .:.....|.|.
Yeast   668 -------------LNTIDLTPNDDKFDLDIQDSIPDFALPPPIIPLRKYGHNFLEKKIFIKLKLR 719

  Fly  1662 NKLEIVKYLLD----------MTNVDVNIPDSEGRTALHVAAWQGH-----ADMVKTLIEAGADV 1711
            ..||.:|...|          ...:..|:|:...|..: :....|.     .|:.:|..|...|.
Yeast   720 PGLESIKLTQDNGIIMSSSPGRITLSSNLPEIIPRNVI-LPVRSGEINNFCKDISETNDEEDDDE 783

  Fly  1712 NSMDLEARTPLHSCAWQGNHDVMNILLYYGALADHACKQGATALGISAQEGHEKCVIALLQFGAN 1776
            .|.|               ||...|:....::.|.:                       :.|...
Yeast   784 ISED---------------HDDGEIIFQVDSIDDFS-----------------------MDFEIF 810

  Fly  1777 PYKSDHCGRTPIKLAAKSSRTSILKIFESYTKNEASNPNEPKFHAHASMLRSPDQPPALPL-HQN 1840
            |       ....::.||:  |::..:|:....|..:..|.|.|....:.:.|      |.| :|.
Yeast   811 P-------SFGTRIIAKT--TAMPFLFKKVAINSIATMNLPLFDTRLNNIGS------LTLDYQI 860

  Fly  1841 LAPYPAHASASSVCSAATTATVHNGSHLHVLNASSSTHSSNNFYQNTMQSDTSSLHKRKSVISSQ 1905
            :.|||                   |:.|.::|...        |..:..||..:..|..:.::|.
Yeast   861 IFPYP-------------------GNPLKIINYEP--------YWKSTGSDLMTSSKDGNFVTSS 898

  Fly  1906 STGSS---------NDQ----APLTFTQ 1920
            |...|         ||:    ||..:.:
Yeast   899 SLNGSFISVLVCALNDETIVAAPKPYVE 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728
		Ank_4	1237..1291	CDD:290365	21/136 (15%)
		ANK	1266..1403	CDD:238125	43/204 (21%)
		ANK repeat	1270..1313	CDD:293786	13/86 (15%)
		Ank_2	1275..1380	CDD:289560	34/170 (20%)
		ANK repeat	1315..1347	CDD:293786	9/37 (24%)
		ANK repeat	1349..1380	CDD:293786	11/47 (23%)
		Ank_2	1354..1449	CDD:289560	24/100 (24%)
		ANK repeat	1382..1413	CDD:293786	10/31 (32%)
		ANK	1410..1538	CDD:238125	20/133 (15%)
		ANK repeat	1415..1446	CDD:293786	4/30 (13%)
		Ank_5	1438..1489	CDD:290568	11/56 (20%)
		ANK	1479..1604	CDD:238125	30/131 (23%)
		ANK repeat	1484..1515	CDD:293786	4/36 (11%)
		Ank_2	1489..1581	CDD:289560	23/92 (25%)
		ANK repeat	1517..1548	CDD:293786	7/30 (23%)
		ANK repeat	1550..1581	CDD:293786	12/31 (39%)
		Ank_2	1555..1648	CDD:289560	24/107 (22%)
		ANK	1578..1705	CDD:238125	29/174 (17%)
		ANK repeat	1617..1648	CDD:293786	4/33 (12%)
		Ank_2	1624..1715	CDD:289560	20/126 (16%)
		ANK	1645..1771	CDD:238125	21/158 (13%)
		ANK repeat	1650..1682	CDD:293786	8/59 (14%)
		ANK repeat	1684..1715	CDD:293786	7/35 (20%)
		Ank_2	1689..1781	CDD:289560	13/96 (14%)
		ANK repeat	1717..1742	CDD:293786	3/24 (13%)
		ANK repeat	1750..1775	CDD:293786	1/24 (4%)
PHO81	NP_011749.3	SPX_PHO81_NUC-2_like	2..159	CDD:269904	26/136 (19%)
		Ank_2	411..482	CDD:403870	19/73 (26%)
		ANK repeat	423..456	CDD:293786	10/35 (29%)
		ANK repeat	458..495	CDD:293786	11/58 (19%)
		PHA02875	466..>650	CDD:165206	52/226 (23%)
		ANK repeat	508..540	CDD:293786	8/31 (26%)
		Ank_2	561..647	CDD:403870	28/106 (26%)
		ANK repeat	561..588	CDD:293786	7/47 (15%)
		ANK repeat	590..622	CDD:293786	12/31 (39%)
		GDPD_NUC-2_fungi	875..1172	CDD:176520	11/60 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24123
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100