DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10011 and CTTNBP2

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	NP_219499.1	Gene:	CTTNBP2 / 83992	HGNCID:	15679	Length:	1663	Species:	Homo sapiens

Alignment Length:	1544	Identity:	279/1544 - (18%)
Similarity:	487/1544 - (31%)	Gaps:	524/1544 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 EAQQQEFKLD-----EAMNNISLSE---NAEELLIEELKRGASECDTKEL-------DNF----Q 476
            ||.::||.:|     |....:|:.|   .|.:|:||.|:....|...:|.       |.|    :
Human    25 EAAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQR 89

  Fly   477 SQRTSTVNKAARTTLTRQQSEPAPLQAMDAVNSDEKTGSNYGTHPPKRASRERGDTE-QDKDMGS 540
            .......:|..:...|.      ||..::||.:..|       ...:|.|.:....| :.|.:..
Human    90 DYEAGAGDKEKKPVCTN------PLSILEAVMAHCK-------KMQERMSAQLAAAESRQKKLEM 141

  Fly   541 EKEQKQSQEPKETPKSSPAKSKSKIPVKRGRSGSGVLSPSKLATISNGGQSIQQGGGEDIADLNT 605
            ||.|.|:.|.:.      .|..:::..:||::...||...|         ..:|..|:.|.:.
Human   142 EKLQLQALEQEH------KKLAARLEEERGKNKQVVLMLVK---------ECKQLSGKVIEEA-- 189

  Fly   606 DQEKHEIEAAIKDDKVEEPQANNE--DKKEDKPEADKELNDQLKEELDKSSQEPKEEETKEEA-T 667
             |:..::.|.::::|.:..:...|  .:|....|.:.::..|| .|.|...::.:.:..:||| |
Human   190 -QKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQL-SEFDTEREQLRAKLNREEAHT 252

  Fly   668 ADSSAEPLID----FTESNVNGKQEEPQLKPPVPGEKPR---ISTNTLPPPLPKTKSCRTIIADG 725
            .|...|  ||    ..|....|...:|.|..|...:..|   ||..| ...:.::.:|:|
Human   253 TDLKEE--IDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGT-EGTVTRSVACQT----- 309

  Fly   726 YYELLLSNPEILECLSVDNIEKNPDECFKKAFLFPLLELTPPKTALLLLIDSIDENYINEGNLIS 790
                             |.:.:|.|...|    .||.....|.|...|:..:.      :|::.:
Human   310 -----------------DLVTENADHMKK----LPLTMPVKPSTGSPLVSANA------KGSVCT 347

  Fly   791 TLKGGRGTVTNHKSRNVAELLSNHIHLFPKWLFLVCTTKKQTKQITKMFTGFKKITLDDLRKSHV 855
            :....|..:....|  ..:|:...:..||.    ....|.:....:...|.....:...|..:..
Human   348 SATMARPGIDRQAS--YGDLIGASVPAFPP----PSANKIEENGPSTGSTPDPTSSTPPLPSNAA 406

  Fly   856 VKDVQEYIINRLNSDFKDSIMLTKEIIESLHQLYIKSNGCILYLEKVLHGIKDNFFSFREIKLIP 920
            ....|...|...||....        :.|||.                                |
Human   407 PPTAQTPGIAPQNSQAPP--------MHSLHS--------------------------------P 431

  Fly   921 CTLNGLYLYICQKSFNKKQYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNYTIDCQEFEKRLQLM 985
            |....|:                 |.||..:.::                          |.:..
Human   432 CANTSLH-----------------PGLNPRIQAA--------------------------RFRFQ 453

  Fly   986 RNILAYDSNAQRLKIFHNSFADWLVDVKFATKKFICDVNEGHVMISMYYLLVADTLCANTVRRFA 1050
            .|....|.|..              ..:....:.:...:..:        |||..|..|||
Human   454 GNANDPDQNGN--------------TTQSPPSRDVSPTSRDN--------LVAKQLARNTV---- 492

  Fly  1051 YHLIRSGEYLTSRHVDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFLPKTRAMLER 1115
                                                                      |:| |.|
Human   493 ----------------------------------------------------------TQA-LSR 498

  Fly  1116 FLASELSEPFAQFLCDFFKPSLP------TDAKMLKLLIET-GINNAESQNSCESSLMSPELSEK 1173
            |.:.:...|        .:|.:|      |...:.:..::| |:...:..|........|.||:.
Human   499 FTSPQAGAP--------SRPGVPPTGDVGTHPPVGRTSLKTHGVARVDRGNPPPIPPKKPGLSQT 555

  Fly  1174 SQNIDFELADLLLSSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHIELHKGKAL 1238
            ......:|         ..::::.||      |...|:..::..:||...|.
Human   556 PSPPHPQL---------KVIIDSSRA------SNTGAKVDNKTVASTPSSLP------------- 592

  Fly  1239 IHILANDGNHQLLERALNACKSP-------IDLEIEDYN----------------GQTALNIAAR 1280
                  .||..:.|..|....||       |||.:....                ....||..|.
Human   593 ------QGNRVINEENLPKSSSPQLPPKPSIDLTVAPAGCAVSALATSQVGAWPAATPGLNQPAC 651

  Fly  1281 NGHLEVVKLLLSF--------SQPCNDGTGRMKRVDVNHADRDGWTP------------------ 1319
            :....|:...::|        :..|..|......|..:     ||:|
Human   652 SDSSLVIPTTIAFCSSINPVSASSCRPGASDSLLVTAS-----GWSPSLTPLLMSGGPAPLAGRP 711

  Fly  1320 --LRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLIESGADVNSVDRQ 1382
              |:.|:..|:..::.:|:.:....|:.:.::|.:||.:||.:||.|.::||:.:.|.||:.|:.
Human   712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKN 776

  Fly  1383 GRTSLIAASYMGHYDIVEILLENGANVNHLDLDGRSALCVAALCGSSGYSKVISTLLDHGANTDQ 1447
            |.|.|.||:..||::.||:|:...||:||. .||
Human   777 GFTPLCAAAAQGHFECVELLISYDANINHA-ADG------------------------------- 809

  Fly  1448 LDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACTAGHATVVKLLLF-----W 1507
                |.:||.::...||.|..:||||...:..:....|.||:.||...|:...:|||::     .
Human   810 ----GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAH 870

  Fly  1508 GCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYAAFEGFHEVCLQLL- 1571
            |...:..:||. :|..:...:.:.|.:.:.:.......|.:..|||..|.||.:||.. ||::|
Human   871 GNSFNEEESES-SVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKN-CLEILC 933

  Fly  1572 -ESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACLEGHMDTVE 1635
             ..|.:.:..|...:|...:|..:    |...|.::::.         |...|::.  |.::...
Human   934 RHGGLEPERRDKCNRTVHDVATDD----CKHLLENLNAL---------KIPLRISV--GEIEPSN 983

  Fly  1636 FLLKFCCDVNSKDADSRTTLYIL-----------------ALENKLEIVK-----YLLDMT---- 1674
            :        .|.|.:...|:..|                 ||.|..:.:.     .|.|:|
Human   984 Y--------GSDDLECENTICALNIRKQTSWDDFSKAVSQALTNHFQAISSDGWWSLEDVTCNNT 1040

  Fly  1675 ---NVDV-----------NIPDSEGRTALHVAAW----QGHADMVKTLIEAGAD--VNSMDLEAR 1719
               |:.:           |:|.|.|::... :.|    :..|:.:..|:....:  ::|:...:.
Human  1041 TDSNIGLSARSIRSITLGNVPWSVGQSFAQ-SPWDFMRKNKAEHITVLLSGPQEGCLSSVTYASM 1104

  Fly  1720 TPL-------------HSCAWQGNHDVMNILLYYGALADHACKQGATALGISAQEGHEKCVIALL 1771
            .||             |:..:.|..         |:|.|:...|.|..|..........|.|...
Human  1105 IPLQMMQNYLRLVEQYHNVIFHGPE---------GSLQDYIVHQLALCLKHRQMAAGFSCEIVRA 1160

  Fly  1772 QFGANPYK--------SDHCGRTPIKLAAKSSRTSILKIFESYTKNEAS 1812
            :..|...|        |..| ..|:|  ...|:..|:.|.|:..|:..|
Human  1161 EVDAGFSKEQLLDLFISSAC-LIPVK--QSPSKKKIIIILENLEKSSLS 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640	10/33 (30%)
		Methylase_S	<772..885	CDD:279728	14/112 (13%)
		Ank_4	1237..1291	CDD:290365	13/76 (17%)
		ANK	1266..1403	CDD:238125	39/180 (22%)
		ANK repeat	1270..1313	CDD:293786	8/66 (12%)
		Ank_2	1275..1380	CDD:289560	29/132 (22%)
		ANK repeat	1315..1347	CDD:293786	8/51 (16%)
		ANK repeat	1349..1380	CDD:293786	13/30 (43%)
		Ank_2	1354..1449	CDD:289560	28/94 (30%)
		ANK repeat	1382..1413	CDD:293786	14/30 (47%)
		ANK	1410..1538	CDD:238125	28/132 (21%)
		ANK repeat	1415..1446	CDD:293786	2/30 (7%)
		Ank_5	1438..1489	CDD:290568	12/50 (24%)
		ANK	1479..1604	CDD:238125	31/131 (24%)
		ANK repeat	1484..1515	CDD:293786	10/35 (29%)
		Ank_2	1489..1581	CDD:289560	24/98 (24%)
		ANK repeat	1517..1548	CDD:293786	4/30 (13%)
		ANK repeat	1550..1581	CDD:293786	12/32 (38%)
		Ank_2	1555..1648	CDD:289560	18/94 (19%)
		ANK	1578..1705	CDD:238125	25/170 (15%)
		ANK repeat	1617..1648	CDD:293786	4/30 (13%)
		Ank_2	1624..1715	CDD:289560	20/136 (15%)
		ANK	1645..1771	CDD:238125	31/184 (17%)
		ANK repeat	1650..1682	CDD:293786	10/71 (14%)
		ANK repeat	1684..1715	CDD:293786	5/36 (14%)
		Ank_2	1689..1781	CDD:289560	18/118 (15%)
		ANK repeat	1717..1742	CDD:293786	4/37 (11%)
		ANK repeat	1750..1775	CDD:293786	5/24 (21%)
CTTNBP2	NP_219499.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		CortBP2	36..180	CDD:286770	34/171 (20%)
		YscO-like	111..270	CDD:293394	40/186 (22%)
		bZIP	119..168	CDD:269834	13/61 (21%)
		coiled coil	119..168	CDD:269834	13/61 (21%)
		RILP-like	<146..263	CDD:304877	29/137 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..222		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..440		15/133 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..478		3/37 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..616		26/159 (16%)
		ANK 1	709..739		5/29 (17%)
		Ank_4	712..764	CDD:290365	14/51 (27%)
		ANK repeat	712..741	CDD:293786	5/28 (18%)
		ANK	738..863	CDD:238125	48/160 (30%)
		ANK repeat	743..774	CDD:293786	13/30 (43%)
		ANK 2	743..772		12/28 (43%)
		Ank_2	748..839	CDD:289560	38/126 (30%)
		ANK repeat	776..807	CDD:293786	14/31 (45%)
		ANK 3	776..805		12/28 (43%)
		ANK repeat	809..840	CDD:293786	11/65 (17%)
		ANK 4	809..838		11/63 (17%)
		Ank_2	814..936	CDD:289560	34/123 (28%)
		ANK 5	842..871		9/28 (32%)
		ANK 6	912..942		12/30 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1449..1482
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1581..1663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3509
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940