DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10011 and TPR10

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	NP_001189808.1	Gene:	TPR10 / 819629	AraportID:	AT3G04710	Length:	680	Species:	Arabidopsis thaliana

Alignment Length:	623	Identity:	136/623 - (21%)
Similarity:	212/623 - (34%)	Gaps:	204/623 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1184 LLLSSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDS----------------HHIEL 1232
            |.|...|..|.|.:.|.:....|:.|.           |:||..                ..:.:
plant     8 LTLPIIKPALPEVRSAATTPVASQKPK-----------HRLSKQLSMCETPRDVAWERRRRQMIM 61

  Fly  1233 HKGKALIHILANDG---NHQLLERALNACKSPIDL--EIEDYNGQTALN-IAARNGHLEVVKLL- 1290
            .:.|.|:|..|:|.   ...|.:..||..|..|:|  ...:..||...| :.|.:.:..|.:.|
plant    62 IQEKKLLHKGASDNLCIQANLTDEDLNELKGSIELGFGFNEEAGQKLCNTLPALDLYFAVNRQLS 126

  Fly  1291 -----------------LSFSQPCNDGTGRMKRVDVNHADRDGWTPLRSASWGGHSEVVRLLIAQ 1338
                             .|:|.||:.     |:.|                    |:.|::|
plant   127 PLPSPSSSRSSSASASTFSYSIPCSP-----KKTD--------------------SDSVKIL--- 163

  Fly  1339 PACKIDLADKEGRTALRAAAWSGHEDILKLLIESGADVNSVDRQGRTSLIAASYMGHYDIVEILL 1403
              |.   .|...:...|...|:       ..:......|..||..:|.:..
plant   164 --CP---GDDPQQMKQRLRHWA-------QAVACSISDNQTDRHKQTPVST-------------- 202

  Fly  1404 ENGAN---------------VNHLDLDGRSALCV---------AALCGSSGYSKVISTLLDHGAN 1444
             ||.|               |:.:..|..:||..         ||..|:..:.|.::..||.|.:
plant   203 -NGTNSDIQNPLQVSRTKGLVSAMAPDASTALAAREKVQQILNAACTGNLEFLKNVAKQLDEGKD 266

  Fly  1445 TDQL-----DNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACTAGHATVVKLL 1504
            ..:.     |.:....|..::.||..|:|..|||.                          :||
plant   267 LTKTVESIKDANKRGALHFAAREGQTEICRYLLEE--------------------------LKL- 304

  Fly  1505 LFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYAAFEGFHEVCLQ 1569
                 ..|..|..|.|.|...|.||.:|||:.||::|.|.......|.|.||:||..|..|:..:
plant   305 -----NADAKDETGDTPLVHAARQGQIETVKYLLEQGADPNIASELGATALHHAAGTGEIELLKE 364

  Fly  1570 LLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACLEGHMDTV 1634
            ||..|..:|. ::|..|.|..||...:.:.|:.||: |::..:.:..|..|....|...|.:..:
plant   365 LLSRGVPVDS-ESESGTPLIWAAGHDQKNAVEVLLE-HNANPNAETEDNITPLLSAVAAGSLSCL 427

  Fly  1635 EFLLKFCCDVNSKDADSRTTLYILALENKLEIVKYLLDMTNVDVNIPDSEGRTALHVAAWQGHAD 1699
            |.|:|         |.::..::                          :.|.|.||:||..|:.:
plant   428 ELLVK---------AGAKANVF--------------------------AGGATPLHIAADIGNLE 457

  Fly  1700 MVKTLIEAGADVNSMDLEARTPLHSCAWQGNHDVMNIL 1737
            ::..|::||||.|..|.|...||...|.:.|..|:.||
plant   458 LINCLLKAGADPNQKDEEGNRPLEVAAARDNRKVVEIL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728
		Ank_4	1237..1291	CDD:290365	16/77 (21%)
		ANK	1266..1403	CDD:238125	23/155 (15%)
		ANK repeat	1270..1313	CDD:293786	12/61 (20%)
		Ank_2	1275..1380	CDD:289560	18/123 (15%)
		ANK repeat	1315..1347	CDD:293786	4/31 (13%)
		ANK repeat	1349..1380	CDD:293786	3/30 (10%)
		Ank_2	1354..1449	CDD:289560	20/123 (16%)
		ANK repeat	1382..1413	CDD:293786	5/45 (11%)
		ANK	1410..1538	CDD:238125	32/141 (23%)
		ANK repeat	1415..1446	CDD:293786	10/39 (26%)
		Ank_5	1438..1489	CDD:290568	12/55 (22%)
		ANK	1479..1604	CDD:238125	35/124 (28%)
		ANK repeat	1484..1515	CDD:293786	3/30 (10%)
		Ank_2	1489..1581	CDD:289560	29/91 (32%)
		ANK repeat	1517..1548	CDD:293786	13/30 (43%)
		ANK repeat	1550..1581	CDD:293786	12/30 (40%)
		Ank_2	1555..1648	CDD:289560	26/92 (28%)
		ANK	1578..1705	CDD:238125	25/126 (20%)
		ANK repeat	1617..1648	CDD:293786	7/30 (23%)
		Ank_2	1624..1715	CDD:289560	19/90 (21%)
		ANK	1645..1771	CDD:238125	23/93 (25%)
		ANK repeat	1650..1682	CDD:293786	0/31 (0%)
		ANK repeat	1684..1715	CDD:293786	13/30 (43%)
		Ank_2	1689..1781	CDD:289560	20/49 (41%)
		ANK repeat	1717..1742	CDD:293786	8/21 (38%)
		ANK repeat	1750..1775	CDD:293786
TPR10	NP_001189808.1	DUF1685	82..>125	CDD:285215	11/42 (26%)
		Alpha_adaptinC2	<202..264	CDD:296022	13/76 (17%)
		Ank_2	245..341	CDD:289560	33/127 (26%)
		ANK	<245..299	CDD:295348	13/53 (25%)
		ANK repeat	282..310	CDD:293786	11/59 (19%)
		ANK	307..431	CDD:238125	41/125 (33%)
		ANK repeat	313..343	CDD:293786	13/29 (45%)
		Ank_2	317..407	CDD:289560	32/91 (35%)
		ANK repeat	345..376	CDD:293786	12/31 (39%)
		ANK repeat	378..407	CDD:293786	8/29 (28%)
		ANK	380..495	CDD:238125	36/150 (24%)
		Ank_2	382..473	CDD:289560	28/126 (22%)
		ANK repeat	410..441	CDD:293786	8/65 (12%)
		ANK repeat	442..473	CDD:293786	13/30 (43%)
		TPR repeat	585..615	CDD:276809
		TPR repeat	620..645	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2422
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000