DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10011 and ankfy1

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	NP_001072887.1	Gene:	ankfy1 / 780349	XenbaseID:	XB-GENE-981436	Length:	1168	Species:	Xenopus tropicalis

Alignment Length:	1082	Identity:	242/1082 - (22%)
Similarity:	389/1082 - (35%)	Gaps:	281/1082 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   926 LYLYICQKSFNKKQYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNYTIDCQEFEKRLQLMRNILA 990
            ::|....|..|:.|...:|.     ....|.:..:.:.||:|.:. |.:.......|.....|:|
Frog   133 IFLTELMKLANRFQLQLLRE-----RCEKGVMSLVNVRNCIRFYQ-TAEELNANALLNYCAEIIA 191

  Fly   991 YDSNAQRLKIFHNSFADWLVDV-----KFATKKFICDVNEGHVMISMYYLLVADTLCANTVRRFA 1050
            ...:..|.:.|.:..|..|..:     :|...|.|....|..|.:   ||:..|:.....:.
Frog   192 SHWDDLRKEDFSSMSAQLLYKMIKSKTQFPLHKAIKLEREDVVFL---YLIEMDSQLPGKLN--- 250

  Fly  1051 YHLIRSGEYLTSRHVDLDLIL-MLLESRL-----NLSDCFYTNQMNCC----AQCEHDFKYDVNF 1105
             .|.::|:      :.|||.| ..|||..     |.:|....::..|.    |.|..| |:..||
Frog   251 -ELDQNGD------LSLDLALSRRLESIATTLVNNKADVDMMDKKGCSLLHKAICRDD-KFAANF 307

  Fly  1106 LPKTRAMLERFLASELSEPF------------AQFLCDFFKPSLPTDAKMLKLLIETGINNAESQ 1158
            |.|..|::......|...|.            .:.:.|.        |::.:.|::.|.|.....
Frog   308 LIKNGALVNAATVGEQQTPLHLVASCTVKDRSVEVMSDI--------AQIAEALLKAGANPNMQD 364

  Fly  1159 NSCESSLMSPELSEKS---------QNIDFELADLLLSSEKSCLMETQRAGSPSEHSEPPAE--- 1211
            :...|.|.:..|:...         :.:|.||.|  .....:..:..|.....|:.|..|.:
Frog   365 SKGRSPLHAAVLARNEYVFNQLLLCKQLDLELKD--HEGSTALWLAVQYITVSSDQSVNPFDDVP 427

  Fly  1212 -----SQDEN--ASSTLHQLSDSHHIELHKGKALIHILANDGNHQL-LERALNACKSPIDLEIED 1268
                 |.|||  |:..:.|.|::...:...|..|:...|..||... |..|.:..|      :..
Frog   428 VVNGTSFDENSFAARLIKQGSNTDAPDTVTGNCLLQRAAAAGNEAASLFLATHGAK------VNH 486

  Fly  1269 YN--GQTALNIAARNGHLEVVKLLL--------SFSQPCND--GTGRMKRVDVNHADRDGWTPLR 1321
            .|  |::.|:.|.|:|...:...||        ...:|...  |.......|..:..    |||.
Frog   487 KNKWGESPLHTACRHGLSNLTAELLQQGANPNIQTQEPITSPRGPPANSLADSTYLQ----TPLH 547

  Fly  1322 SASWGGHSEVVRLLIAQPACKI------------DLADKEGRTALRAAAWSGHEDILKLLIESGA 1374
            .|....|.:||.:::.|.|..:            .|.|...:|.|..|.|:|...|...|:.|||
Frog   548 MAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSREQTVLGLALWTGMHTIAAQLLGSGA 612

  Fly  1375 DVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLDGRSALCVA----------ALCG-- 1427
            .:|.....|:|.|..|...........|||:.|::|....||.:||.:|          |:|.
Frog   613 SINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTRDGETALQLAIKNQLPLVVDAICTRG 677

  Fly  1428 ------------------SSGYSKVISTLLDHGA-----------------------NTDQL--- 1448
                              .:....:.|||:.||.                       |.:|:
Frog   678 ADMSVTDEQGNPPLWLALENEQEDIASTLVRHGCDATFWGPGPSGCQQTLLHRAIDENKEQIACF 742

  Fly  1449 -----------------------DNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLW 1490
                                   ..||.:||.:::..|..||.:.|||..|:.:..|..||||:.
Frog   743 IIRSGCDVNSTRKPGPNGEGEEEARDGQTPLHLAASWGLEEVVQCLLEFGANVNTQDAEGRTPIH 807

  Fly  1491 AACTAGHATVVKLLLF----------------WGCGI-------------------DCMDSEGRT 1520
            .|.:..|..:::||:.                :.|.:                   :.:|::||.
Frog   808 VAISNQHRVIIQLLISHPDIRLNVRDRQGMTPFACAMTFKNNKAAEAILKREPGAAEQVDNKGRN 872

  Fly  1521 VLSIGAAQGNVETVRQLL--DRGLDETHRDNAGWTPLHYAAFEGFHEVCLQLLESGAKIDECDNE 1583
            .|.:.....::|:|..|:  ...::...:|.:..||||.|...|...:...||.:|||::|....
Frog   873 FLHVAVQNSDIESVLFLISVQANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKH 937

  Fly  1584 GKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHD--GKTAFRLACLEGHMDTVEFLLKFC-CDVN 1645
            .:||||||||:........||:   :.||..|.|  |..|..||.:.|.::.:..||..| .|..
Frog   938 RQTALHLAAQQDLPVICSVLLE---NGVDFSAADENGNNALHLAIMHGRLNNIRCLLTECNVDAE 999

  Fly  1646 SKDADSRTTLYIL---ALENKLEIVKYLLD-MTNVDVNIPDSEGRTALHVAAWQGHADMVKTLIE 1706
            :.:...::.::||   ..||...|.:..|: |....::.||:||.|.|.:|..:|:|::.:.:::
Frog  1000 ALNLRGQSPMHILGQYGKENAAAISELFLECMPQYPLDKPDAEGNTVLLLAYMKGNANLCRAIVK 1064

  Fly  1707 AGA--DVNSMDLEARTPLHSCAWQGNHDVMNILLYYGALADHACKQGAT------ALGISAQE-- 1761
            |||  .||                 |...:||..|          |.||      .|.:.:||
Frog  1065 AGARLGVN-----------------NSQGINIFNY----------QVATKQLLFRLLDMLSQEPP 1102

  Fly  1762 --GHEKCVIALLQFGANPYKSD--HCGRTPIKLAAKSSRTSI 1799
              ....|.....:||....|..  ||||.   |.:|.|...|
Frog  1103 WCDGSNCYECAAKFGVTTRKHHCRHCGRL---LCSKCSTKEI 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728
		Ank_4	1237..1291	CDD:290365	13/56 (23%)
		ANK	1266..1403	CDD:238125	37/160 (23%)
		ANK repeat	1270..1313	CDD:293786	11/54 (20%)
		Ank_2	1275..1380	CDD:289560	31/126 (25%)
		ANK repeat	1315..1347	CDD:293786	10/43 (23%)
		ANK repeat	1349..1380	CDD:293786	11/30 (37%)
		Ank_2	1354..1449	CDD:289560	33/173 (19%)
		ANK repeat	1382..1413	CDD:293786	9/30 (30%)
		ANK	1410..1538	CDD:238125	42/241 (17%)
		ANK repeat	1415..1446	CDD:293786	13/83 (16%)
		Ank_5	1438..1489	CDD:290568	20/99 (20%)
		ANK	1479..1604	CDD:238125	38/161 (24%)
		ANK repeat	1484..1515	CDD:293786	9/65 (14%)
		Ank_2	1489..1581	CDD:289560	25/128 (20%)
		ANK repeat	1517..1548	CDD:293786	6/32 (19%)
		ANK repeat	1550..1581	CDD:293786	12/30 (40%)
		Ank_2	1555..1648	CDD:289560	33/95 (35%)
		ANK	1578..1705	CDD:238125	40/133 (30%)
		ANK repeat	1617..1648	CDD:293786	10/33 (30%)
		Ank_2	1624..1715	CDD:289560	28/97 (29%)
		ANK	1645..1771	CDD:238125	32/141 (23%)
		ANK repeat	1650..1682	CDD:293786	7/35 (20%)
		ANK repeat	1684..1715	CDD:293786	12/32 (38%)
		Ank_2	1689..1781	CDD:289560	23/103 (22%)
		ANK repeat	1717..1742	CDD:293786	4/24 (17%)
		ANK repeat	1750..1775	CDD:293786	8/34 (24%)
ankfy1	NP_001072887.1	BTB_POZ_Rank-5	50..169	CDD:349612	8/40 (20%)
		BACK_ANKFY1_Rank5	162..250	CDD:350576	19/91 (21%)
		ANK repeat	221..253	CDD:293786	7/38 (18%)
		ANK repeat	255..286	CDD:293786	10/36 (28%)
		Ank_2	274..>568	CDD:393464	65/314 (21%)
		ANK repeat	289..319	CDD:293786	10/30 (33%)
		ANK repeat	321..364	CDD:293786	7/50 (14%)
		ANK repeat	491..521	CDD:293786	7/29 (24%)
		ANK repeat	541..585	CDD:293786	10/47 (21%)
		ANKYR	548..747	CDD:223738	42/198 (21%)
		ANK repeat	587..618	CDD:293786	11/30 (37%)
		ANK repeat	620..651	CDD:293786	9/30 (30%)
		ANK repeat	653..684	CDD:293786	7/30 (23%)
		ANK repeat	686..711	CDD:293786	4/24 (17%)
		PHA03095	701..>992	CDD:222980	68/293 (23%)
		ANK repeat	725..766	CDD:293786	2/40 (5%)
		ANK repeat	768..799	CDD:293786	11/30 (37%)
		ANK repeat	801..833	CDD:293786	8/31 (26%)
		ANK repeat	874..902	CDD:293786	4/27 (15%)
		ANK repeat	904..935	CDD:293786	12/30 (40%)
		ANK repeat	937..968	CDD:293786	13/33 (39%)
		ANK repeat	970..1002	CDD:293786	9/31 (29%)
		FYVE_ANFY1	1100..1162	CDD:277267	13/45 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010