Protein Alignment CG10011 and Tanc2

DIOPT Version :10

• Sequence 1: NP_651624.2
• Gene: CG10011 / 43387
• FlyBaseID: FBgn0039590
• Length: 2119
• Species: Drosophila melanogaster
• Sequence 2: XP_006534535.1
• Gene: Tanc2 / 77097
• MGIID: 2444121
• Length: 2079
• Species: Mus musculus
• Alignment Length: 1996
• Identity: 434/1996 - (21%)
• Similarity: 707/1996 - (35%)
• Gaps: 574/1996 - (28%)

  Fly   434 QQEF----KLDEAMNNIS------LSENAEELLIEELKRGASECDTKELDNFQSQRTSTVNKAAR 488
            :||.    .:|||.|.:.      |.|...|  ::...:.:.|...:...:..:||.|..:....
Mouse   148 EQELGPPPSVDEAANTLMTRLGFLLGEKVTE--VQPSDQYSMEVQDENQTSAITQRISPCSTLTS 210

  Fly   489 TTLTRQQSEPAPLQAMDAVNSDEKTGSNYGTHPPKRASRERGDT--------------------E 533
            :|.:...|.|.......:.|:..|..| ||......::.|..|:                    |
Mouse   211 STASPPASSPCSTLPPVSTNAAAKDCS-YGAVTSPTSTLESRDSGIIATLTNYSENMERTKYVGE 274

  Fly   534 QDKDMGSEKEQKQSQEPKETPKS----------SPAKSKSKIPVKRGRSGSGVLS------PSKL 582
            ..|::||....|..|..|.:..|          :...|.:|||   .|:...|||      |..|
Mouse   275 GSKELGSGGNLKPWQSQKSSMDSCLYRVDENMAASTYSLNKIP---ERNLETVLSQSVQSIPLYL 336

  Fly   583 ATISNGGQSIQQGGGEDIADLNTDQEKH-------------------------------EIEAAI 616
            ....|...:......||:|.|  |:::|                               ..:.::
Mouse   337 MPRPNSVAATSSAHLEDLAYL--DEQRHTPLRTSLRMPRQSLSGARTQQDLRVRFAPYRPPDISL 399

  Fly   617 KDDKVEEPQANNEDKKEDKPEADKELNDQLKEE-------------------------------- 649
            |....|.|....|.....:.....|::.||:..
Mouse   400 KPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHG 464

  Fly   650 -------LDKSSQEPKEEETKEEATADSSAEPLIDFTESNVNG------KQEEP--QLKPPVPGE 699
                   .|.....||..:...|.....:.......|..:..|      :|||.  :|...|...
Mouse   465 TRMRQIASDSPHASPKHVDANRELPLTQAPSAHSSITSGSCPGTPEMRRRQEEAMRRLASQVVAY 529

  Fly   700 KPRISTNTLPPPLPK------TKSCRTIIADGYYELLLSNPEILECLSVDNIEKNPDECFKKAFL 758
            ....:.|.....:|:      ...||:.....|.|.||..|.:...||:.:..::|...|::..|
Mouse   530 HYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVL 594

  Fly   759 FPLLELTP----PKTALLLLIDSIDENYINEGNLISTLKGGRGTVTNHKSRNVAELLSNHIHLFP 819
            .||..|..    |....::|||.::|...::.:...|               :...||..|..||
Mouse   595 EPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDT---------------IVSFLSKMIGNFP 644

  Fly   820 KWLFLVCTTKKQTKQITKMFTGFKKITLDDLRKSHVV-KDVQEYIINRL--NSDFKDSIMLTKEI 881
            .||.|:.|.:...::|||:.. |.:|.||.|.::..: :|:|.||::|:  :|:.:::|.|..::
Mouse   645 SWLKLIVTVRTSLQEITKLLP-FHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNNISLNGKM 708

  Fly   882 IE------SLHQLYIKSNGCILYLEKVLHGIKDNFFSFR--EIKLIPCTLNGLYLYICQKSF-NK 937
            ..      |.| |...|.|..|||:.....|:..:...:  ..|::|.:|:.:||..|...| .:
Mouse   709 DNTTFGKLSSH-LKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQ 772

  Fly   938 KQYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNY--TIDCQEFEKRLQLMRNILAYDSNAQRLKI 1000
            ..:.::.|||||.:||...:....:|..:...:.  |::.::|::|::.:...|....:..|:.:
Mouse   773 SSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFV 837

  Fly  1001 FHNSFADWLVDVKFATK-KFICDVNEGHVMISMYYLLVADTLCANTVRRFAYHLIRSGEYLTSRH 1064
             |.||.:||:..:...| ||:||...||.:::.::......|.........:|::::
Mouse   838 -HPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKA-------- 893

  Fly  1065 VDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFLPKTRAMLERFLASELSEPFAQFL 1129
                                            |.||.....:..:.::|:....|..:|..:..|
Mouse   894 --------------------------------HIFKGLSKKVGVSSSILQGLWISYSTEGLSMAL 926

  Fly  1130 C---DFFKPSLPTDAKMLKLLIETGIN---NAESQNSCESSLMSPELSEKSQNIDFELADLLLSS 1188
            .   :.:.|::    |:.:|||..|.|   ..|..|:      :|.|..:|.....|:..|||..
Mouse   927 ASLRNLYTPNI----KVSRLLILGGANINYRTEVLNN------APILCVQSHLGYTEMVALLLEF 981

  Fly  1189 EKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHIELHKGKALIHILANDGNHQLLER 1253
                                 ..:.|.::.|.|..|          |.|     |..|   .|..
Mouse   982 ---------------------GANVDASSESGLTPL----------GYA-----AAAG---FLSI 1007

  Fly  1254 ALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPCNDGT--GRMKRV-DVNHADRD 1315
            .:..||....::..|.|||.||..||..|||||||.|:.    | |.|  |:.:.| ..:||.:.
Mouse  1008 VVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQ----C-DWTMAGQQQGVFKKSHAIQQ 1067

  Fly  1316 GWTPLRSASWGGHSEVVRLLIAQPACKIDLADKE----------------GRTALRAAAWSGHED 1364
            .   |.:|:..|::|:|..|       :||.:|:                |.|||.|||..|..|
Mouse  1068 A---LIAAASMGYTEIVSYL-------LDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLD 1122

  Fly  1365 ILKLLIESGADVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLDGRSALCVAALCGSS 1429
            :.:||:|.||.|...:|:|...|.:....||:.||::||.:||:||..|..||:.|.:||   |.
Mouse  1123 VCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAA---SE 1184

  Fly  1430 GYSKVISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACT 1494
            |:...:..||..||:...:|.:|::.|..:..:|:..|...|::|.|..|.||..|||||..|..
Mouse  1185 GHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAF 1249

  Fly  1495 AGHATVVKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRG-------LDETHRDNAGW 1552
            .|.|.||:.|:..|..|:.:|..|...|.......|...|..||.:|       |....|..|.|
Mouse  1250 YGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQTLPSRPRGPATW 1314

  Fly  1553 TPLHYAAFEGFHEVCL----QLLESG------AKIDECDNEGKTALHLAAQEG--------RLHC 1599
                 |......::.:    :|:|.|      .|:.|.....:.||....:||        |...
Mouse  1315 -----AMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELK 1374

  Fly  1600 VQALLDIHSSFVDQKAHDGKTA--FRLACLEGHMDTVEFLLKFCCDVNSKDADSRTTLYILALEN 1662
            |..||::  |...:|.:|...|  |....||....:.|   .:.....:|.:.||.  :..|||:
Mouse  1375 VSLLLNL--SRCRRKMNDFGMAEEFATKALELKPKSYE---AYYARARAKRSSSRQ--FAAALED 1432

  Fly  1663 KLEIVKYLLDMTNVDV-------------------------------NIPDSEGRTALHVAAWQG 1696
            ..|.:|  |...|.::                               .:|:.|....      ..
Mouse  1433 LKEAIK--LCPNNREIQRLLMRVEEECRQMQQQQQQQPPPPPQQPPQELPEEETEPE------PQ 1489

  Fly  1697 HADM--VKTLIE---AGADVNSMDL----EAR-------------TPLH------SCAWQGNHDV 1733
            |.|:  |:.:.|   ...||.::.:    |||             :|.|      |.:..|:|.|
Mouse  1490 HEDIYSVQDIFEEEYLEQDVENVSIGLQTEARPSQGLPVIQSPPSSPAHRDSAYISSSPLGSHQV 1554

  Fly  1734 MNILLYYGALADHACKQGATALGISAQEGHEKCVIALLQFGAN-------PYKSD-HCGR----- 1785
            .:.             :..:::|...::|::....||.....|       |:.|. |.|.
Mouse  1555 FDF-------------RSNSSVGSPTRQGYQSTSPALSPTHQNSHYRPSPPHTSPAHQGASYRFS 1606

  Fly  1786 ----------------TPIKLAAK---SSRTSILKIFESYT---------KNEASNPNEPKFHAH 1822
                            :|::...:   |.....:.::.|.:         .|.:..|..|| ...
Mouse  1607 PPPVGGQSKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETNVSQLPGRPK-SPL 1670

  Fly  1823 ASMLRSPDQPPALPL---HQNLAPYPAHASASSVCSAATTATVHNGSHLHVLNASSSTHSSNNFY 1884
            :.|.:.|.|.|.||:   .|.|...|  |.|..|.|...::.||:.:.:.........||..:.|
Mouse  1671 SKMAQRPYQMPQLPVAVPQQGLRLQP--AKAQIVRSNQPSSAVHSSTVIPTGAYGQVAHSMASKY 1733

  Fly  1885 QNTMQSDTSSLHKRKSVISSQSTGSSNDQAPLTFTQQLQRQSKLSSRNNLMVNSKHASSSGAAGH 1949
            |:: |.| ..:.:.:.|......|...|..|:                      :|..:|.:||.
Mouse  1734 QSS-QGD-MGVSQSRLVYQGSIGGIVGDGRPV----------------------QHVQASLSAGA 1774

  Fly  1950 KSSGGG--------------GGAQRHSQVLPDLSEHQLASNMTNEADMYDMECMSPLYATPPHSP 2000
            ....||              .|..|:||. |.:...|.||        |...|.|.|
Mouse  1775 ICQHGGLTKEDLPQRPSSAYRGGMRYSQT-PQIGRSQSAS--------YYPVCHSKL-------- 1822

  Fly  2001 SSELSSPGQLPGLNAFVDDERAGTSSGGGAKLPD-NHFARDTHMRIILGNLKENQPSSSGKSKRS 2064
                             |.||:.:..|.    || :|..|    |.|..|..|.:|..
Mouse  1823 -----------------DLERSSSQLGS----PDVSHLIR----RPISVNPNEIKPHP------- 1855

  Fly  2065 GVSSNPAMR-LIRS-----RFDAASQLIRRTNNILSSSSNQGSSSI 2104
                 |..| |:.|     ||..:|..|..|:|:  :.:.:.||||
Mouse  1856 -----PTPRPLLHSQSVGLRFSPSSNSISSTSNL--TPTFRPSSSI 1894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	ANKYR	1236..1489	CDD:440430	92/271 (34%)
		ANK repeat	1270..1313	CDD:293786	21/45 (47%)
		ANK repeat	1315..1347	CDD:293786	8/31 (26%)
		ANK repeat	1349..1380	CDD:293786	15/46 (33%)
		ANK repeat	1382..1413	CDD:293786	12/30 (40%)
		ANK repeat	1415..1446	CDD:293786	11/30 (37%)
		ANKYR	1469..1788	CDD:440430	89/433 (21%)
		ANK repeat	1484..1515	CDD:293786	13/30 (43%)
		ANK repeat	1517..1548	CDD:293786	8/37 (22%)
		ANK repeat	1550..1581	CDD:293786	8/40 (20%)
		ANK repeat	1617..1648	CDD:293786	6/32 (19%)
		ANK repeat	1650..1682	CDD:293786	9/62 (15%)
		ANK repeat	1684..1715	CDD:293786	7/35 (20%)
		ANK repeat	1717..1742	CDD:293786	9/43 (21%)
		ANK repeat	1750..1775	CDD:293786	4/24 (17%)
Tanc2	XP_006534535.1	PHA03095	930..>1224	CDD:222980	104/360 (29%)
		ANK repeat	963..989	CDD:293786	7/46 (15%)
		ANK repeat	991..1022	CDD:293786	10/48 (21%)
		ANKYR	1100..1299	CDD:440430	72/201 (36%)
		ANK repeat	1108..1138	CDD:293786	15/29 (52%)
		ANK repeat	1140..1171	CDD:293786	12/30 (40%)
		ANK repeat	1174..1204	CDD:293786	11/32 (34%)
		ANK repeat	1206..1237	CDD:293786	8/30 (27%)
		ANK repeat	1239..1270	CDD:293786	13/30 (43%)
		ANK repeat	1272..1302	CDD:293786	7/29 (24%)
		TPR repeat	1331..1356	CDD:276809	6/24 (25%)
		TPR	1335..>1450	CDD:440225	29/123 (24%)
		TPR repeat	1361..1404	CDD:276809	12/44 (27%)
		TPR repeat	1409..1438	CDD:276809	8/33 (24%)
		PAT1	1525..>1717	CDD:401645	37/207 (18%)