Protein Alignment CG10011 and Tanc1

DIOPT Version :10

• Sequence 1: NP_651624.2
• Gene: CG10011 / 43387
• FlyBaseID: FBgn0039590
• Length: 2119
• Species: Drosophila melanogaster
• Sequence 2: XP_006500097.1
• Gene: Tanc1 / 66860
• MGIID: 1914110
• Length: 1874
• Species: Mus musculus
• Alignment Length: 2102
• Identity: 418/2102 - (19%)
• Similarity: 702/2102 - (33%)
• Gaps: 660/2102 - (31%)

  Fly   270 KEVNG-------LVHSAGVEPNNRIVSTVYIHREWVLKKIALCL-------------EQRTAGKK 314
            ||..|       .:.|:|..|.|.:.:|...:|..:.|.:::.|             :.|:..|.
Mouse    18 KEAGGDFGSETPALSSSGDSPVNSLSTTEDTYRVSLAKGVSMSLPSSPLLPRQSLLTQSRSNKKS 82

  Fly   315 SGPVALGGAASSSYVSARAKAAAISSSSYNGCLVLGSNGSGKTSICQAIMKGNSGTKGILNRKLL 379
            .|||              .|...:.|....|..|:...|.|...      ...|.|:...:.:
Mouse    83 PGPV--------------RKPKYVESPRVPGDPVMIPFGEGSKP------SEPSATEAKADNE-- 125

  Fly   380 ACYLIESQNPECHSLSLFMRKIVLQLLSHASLISRDESQRIIDEGFSFLRDEAQQQEFKLDEAMN 444
                     |.|...:       .:||:....        ::.||.               .:..
Mouse   126 ---------PSCSPAA-------QELLTRLGF--------LLGEGI---------------PSAT 151

  Fly   445 NISLSENAEELLIEE-----------------LKRGASECDT-------KELDNFQSQRTSTVNK 485
            :|::.:..|.:::.|                 |.:|.|.|.|       ...|:..|...|.|:|
Mouse   152 HITIEDKNEAMVMPEEEAAFPTCSACTLPCTALSQGISPCSTLTSSTASPSTDSPCSTLNSCVSK 216

  Fly   486 --AARTTLTRQQSEPAPLQAMD---------AVNSDEKTGSN--YGTHPPKRASRERG---DTEQ 534
              |:::......|..:.|::.|         :..:|:::||:  :......|...::|   |...
Mouse   217 TAASKSPCETISSPSSTLESKDSGIIATITSSSENDDRSGSSLEWNRDGSLRLGVQKGVLHDRRA 281

  Fly   535 DKDMGSEKEQKQSQEPKETPKSSPAKSKSKIPVKRGRSGSGVLSP---SKLATISNGGQSIQQGG 596
            |......:|:.........||:.|:.....:|..:. ||| ::.|   |..||.|...:.:....
Mouse   282 DNCSPVAEEETTGSAESVLPKAEPSAGDGPVPYPQS-SGS-LIMPRPNSVAATSSTKLEDLSYLD 344

  Fly   597 GEDIADLNTDQEKHEIEAAIKDDKVEEPQANN------EDKKEDKPEADKEL------------- 642
            |:..|.|.|              .:..|..|.      |.|....|...:|:
Mouse   345 GQRNAPLRT--------------SIRLPWHNTAGGRAPEVKARFAPYKPQEILLKPLLFEVPSIT 395

  Fly   643 -------NDQLKEELDKSSQEPKEEETKEEATADSSAEPLIDFTESNVNGK-------------- 686
                   .|.|..:::::.:..:..|.:......|     :.|.::.:..|
Mouse   396 TDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGS-----VGFGKTAIISKLVALSCHGSRMRQI 455

  Fly   687 -QEEPQLKP-------PVPGE---KPRISTNTL----PPPLPKTKS------------------- 717
             ...|.|.|       .:||.   .|..||:.|    .|..|.|..
Mouse   456 ASSSPSLSPKSSDPTQDLPGTPLLSPSSSTSALSVTRTPAGPGTADSQRPREDAVKYLASKVVAY 520

  Fly   718 ------------------------CRTIIADGYYELLLSNPEILECLSVDNIEKNPDECFKKAFL 758
                                    ||:.....|.:||:..|::...||:.:..::|...||:..|
Mouse   521 HYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIKEPQLQSMLSLRSCVQDPVAAFKRGVL 585

  Fly   759 FPLLELTP----PKTALLLLIDSIDENYINEGNLISTLKGGRGTVTNHKSRNVAELLSNHIHLFP 819
            .||..|..    |:...::|||.::|...::.:...||               :..::..|..||
Mouse   586 EPLTSLRNEQKIPEEEYIILIDGLNEAEFHKPDYGDTL---------------SSFITKIIPKFP 635

  Fly   820 KWLFLVCTTKKQTKQITKMFTGFKKITLDDL-RKSHVVKDVQEYIINRLNS--DFKDSIMLTKEI 881
            .||.|:.|.:...::|..... |.|::|||. ....:..|:..|:.:|::|  |...:|.|..:.
Mouse   636 TWLKLIVTVRANFQEIISALP-FVKLSLDDFPDNKDIHSDLHAYVQHRVHSSQDILSNISLNGKA 699

  Fly   882 IESL-----HQLYIKSNGCILYLEKVLHGIKDNFFSFR--EIKLIPCTLNGLYLYICQKSF-NKK 938
            ..:|     ..|.::|.|..|||:..|...:......:  ..|::|.:|:.|||..|...| .:.
Mouse   700 DAALISKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYKVVPVSLSELYLLQCNMKFMTQS 764

  Fly   939 QYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNYTID--CQEFEKRLQLMRNILAYDSNAQRLKIF 1001
            .:.:..|:|||.|||...:....:|..:...:...:  .::|::|::.:...|....:..|: ..
Mouse   765 AFDRALPILNVALASLHPMTDEQIFQAINAGHIQGEQGWEDFQQRMEALSCFLIKRRDKTRM-FC 828

  Fly  1002 HNSFADWLV-DVKFATKKFICDVNEGHVMISMYYLLVADTLCANTVRRFAYHLIRSGEYLTSRHV 1065
            |.||.:||| .....:..|:|:...||.:::..:......|.........:|::::
Mouse   829 HPSFREWLVWRADGESTAFLCEPRNGHALLAFMFSRQESKLNRQQTMELGHHILKA--------- 884

  Fly  1066 DLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFLPKT-------RAMLERFLASELSE 1123
                                           |.||   ....||       :|:...:....||.
Mouse   885 -------------------------------HIFK---GLSKKTGVSSSHLQALWIGYSTEGLSA 915

  Fly  1124 PFAQFLCDFFKPSLPTDAKMLKLLIETGINNAESQNSCESSLMSPELSEKSQNIDFELADLLLSS 1188
            ..|. |.:.:.|::    |:.:|||..|.|
Mouse   916 ALAS-LRNLYTPNV----KVSRLLILGGAN----------------------------------- 940

  Fly  1189 EKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHIELHKGKALIHILANDGNHQLLER 1253
                                                                             
Mouse   941 ----------------------------------------------------------------- 940

  Fly  1254 ALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPCNDGTGRMKRVDVNHADRDGWT 1318
                    ::...|..|....|.:.:..||.|||.|||.|. .|.||           ...:|..
Mouse   941 --------VNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFG-ACLDG-----------MSENGMN 985

  Fly  1319 PLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLI----ESGADVNSV 1379
            .|..|:..||.::|.|||.:.| ::|..||:|:.||..:|..||.|||:.|:    .:|......
Mouse   986 ALCYAAAAGHMKLVCLLIKKGA-RVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPPQPGT 1049

  Fly  1380 DRQGRT---SLIAASYMGHYDIVEILL----ENGANVNHLD-LDGRSALCVAALCGSSGYSKVIS 1436
            .|:.:.   :|.||:.|||..:|:.||    |:...||..| |.|.:||..||   ..|..::..
Mouse  1050 LRKSQALQQALTAAASMGHSSVVQSLLGMAEEHEIEVNGTDTLWGETALTAAA---GRGKVEICE 1111

  Fly  1437 TLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACTAGHATVV 1501
            .||:.||...:.:..|:.||..::.:|:.:|..|||:...|.:|:|..|||||..|...||.:.|
Mouse  1112 LLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTV 1176

  Fly  1502 KLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYAAFEGFHEV 1566
            :.||..|..:..:|.||.:.||....:|:...|:.|::.|.:....|..|.|||..|||.|..|.
Mouse  1177 EFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAET 1241

  Fly  1567 CLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACLEGHM 1631
            .|.|:|.||.|:..|:.|...|..|     :.|....:.:  :.:.:.|..|..|:.:|  ....
Mouse  1242 VLYLVEKGAVIEHVDHSGMRPLDRA-----IGCRNTAVVV--TLLRKGAKLGNAAWAMA--TSKP 1297

  Fly  1632 DTVEFLLKFCCDVNS--------KDADSRTTLYILALE--------------NKLEIVKYL---- 1670
            |.:..||:...:..:        |:|..|   |..||.              |:|.:..||
Mouse  1298 DILIILLQKLVEEGNVMYKKGKMKEAAQR---YQYALRKFPREGLGEDMRPFNELRVSLYLNLSR 1359

  Fly  1671 -LDMTNVDVNIPDSEGRTALHVAAWQGHADMVKTLIEAGADVNS-------MDLEARTPLHSCAW 1727
             ...|| |..:.:.....||.:......|...:    |.|..||       .||:....|  |
Mouse  1360 CRRKTN-DFGLAEEFASKALELKPKSYEAFYAR----ARAKRNSRQFLAALADLQEAVKL--C-- 1415

  Fly  1728 QGNHDVMNILLYYGALADHACK----------QGATALGISAQEGHEKCVIALLQFGANPYKSDH 1782
            ..|.::..:|    |..:..||          ||......:..:..|....:.|:        ||
Mouse  1416 PNNQEIKRLL----ARVEEECKQLQRNQQQKQQGPPPAPANDSDNEEDAPASSLK--------DH 1468

  Fly  1783 CGRTPIKLAAKSSRTSILKIFESYTKNEASNPNEPKFHAHASMLRSPDQPPALP------LHQNL 1841
               .||:.|.:...:|   ..||.:....|.|                 ||::|      |.:.|
Mouse  1469 ---FPIEEAEEEDTSS---QEESISPTPRSQP-----------------PPSVPSPYIRNLQEGL 1510

  Fly  1842 APYPAHASASS---VCSAATTATVHNG-------------SHLHVLNASSSTHSSNNFYQNTMQS 1890
            ......||..|   :..:.......:|             ::.|:.:..||..:|:...|.:.|:
Mouse  1511 QSKGRSASPQSRAGISKSLRETVAQSGLVMQPTKQAQIVKTNQHLGSGQSSMRNSSTKIQVSSQN 1575

  Fly  1891 -DTSSLHKRKSVISSQS----------------TGSSNDQAPLTFTQQLQRQ---------SKLS 1929
             ..|.:..|.|...:.|                .|...|:...:.:.||||.         ||:.
Mouse  1576 PPPSPMPGRVSAAPAVSRNQHLEGTGPFTAGTGCGHFGDRLGASQSLQLQRSESGTAYPLPSKVK 1640

  Fly  1930 SRNNLMVNSKHASSSGAAGHKSSGGGGGAQ--RHSQVLPDLSEHQLASNMTNEADMYDMECMSPL 1992
            :...|:.   |||.:......:.||.....  ||..        .|:|:.::
Mouse  1641 AAERLLA---HASVAVDMAPPNQGGPVSCSDVRHPA--------SLSSSGSS------------- 1681

  Fly  1993 YATPPHSPSSELSSPGQLPGLNAFVDDERAGTSSGGGAKLPDNHFARDTHMRIILGNLKENQPSS 2057
                 .||||.:........|.:     .:..|.|...:.||:.. ||.....:.|...|::|.:
Mouse  1682 -----GSPSSSIKMSSSTSSLTS-----SSSVSDGFKVQGPDSRI-RDKGTTQVQGGTAEHRPRN 1735

  Fly  2058 S------GKSKRSGVSSNPAMR 2073
            :      .|:.|....|||..|
Mouse  1736 TPFMGIMDKTARFQQQSNPPNR 1757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	ANKYR	1236..1489	CDD:440430	78/264 (30%)
		ANK repeat	1270..1313	CDD:293786	14/42 (33%)
		ANK repeat	1315..1347	CDD:293786	11/31 (35%)
		ANK repeat	1349..1380	CDD:293786	11/34 (32%)
		ANK repeat	1382..1413	CDD:293786	12/37 (32%)
		ANK repeat	1415..1446	CDD:293786	10/30 (33%)
		ANKYR	1469..1788	CDD:440430	90/362 (25%)
		ANK repeat	1484..1515	CDD:293786	12/30 (40%)
		ANK repeat	1517..1548	CDD:293786	8/30 (27%)
		ANK repeat	1550..1581	CDD:293786	15/30 (50%)
		ANK repeat	1617..1648	CDD:293786	6/38 (16%)
		ANK repeat	1650..1682	CDD:293786	11/50 (22%)
		ANK repeat	1684..1715	CDD:293786	7/37 (19%)
		ANK repeat	1717..1742	CDD:293786	4/24 (17%)
		ANK repeat	1750..1775	CDD:293786	4/24 (17%)
Tanc1	XP_006500097.1	DUF5585	109..>383	CDD:465521	56/336 (17%)
		NACHT	<536..1157	CDD:444362	173/809 (21%)
		PHA03095	921..>1233	CDD:222980	108/439 (25%)
		ANK repeat	954..980	CDD:293786	13/37 (35%)
		ANK repeat	986..1013	CDD:293786	10/27 (37%)
		ANK repeat	1015..1090	CDD:293786	24/74 (32%)
		ANKYR	1094..1310	CDD:440430	70/227 (31%)
		ANK repeat	1094..1124	CDD:293786	10/32 (31%)
		ANK repeat	1130..1157	CDD:293786	9/26 (35%)
		ANK repeat	1160..1190	CDD:293786	12/29 (41%)
		ANK repeat	1192..1223	CDD:293786	8/30 (27%)
		ANK repeat	1225..1256	CDD:293786	15/30 (50%)
		ANK repeat	1258..1283	CDD:293786	4/31 (13%)
		TPR repeat	1307..1332	CDD:276809	5/27 (19%)
		TPR	1311..>1428	CDD:440225	27/132 (20%)
		TPR repeat	1350..1380	CDD:276809	7/30 (23%)
		TPR repeat	1385..1413	CDD:276809	7/31 (23%)