Protein Alignment CG10011 and tanc2a

DIOPT Version :10

• Sequence 1: NP_651624.2
• Gene: CG10011 / 43387
• FlyBaseID: FBgn0039590
• Length: 2119
• Species: Drosophila melanogaster
• Sequence 2: XP_068075010.1
• Gene: tanc2a / 568810
• ZFINID: ZDB-GENE-060130-180
• Length: 2044
• Species: Danio rerio
• Alignment Length: 2029
• Identity: 400/2029 - (19%)
• Similarity: 662/2029 - (32%)
• Gaps: 670/2029 - (33%)

  Fly   365 KGNSGTKGILNRKLLACYLIESQ-NPECHSLSLFMRKIVLQLLSHASLISRDESQRIIDEGFSFL 428
            |.|.|..|       |.|.:|.| :|:|.|::        |.:|..|.::...:........|.|
Zfish   162 KVNEGPAG-------AQYTMEEQDDPQCLSMT--------QRISPCSSLASSTASPPAGSPCSTL 211

  Fly   429 RDEAQQQEFKLDEAMNNI-------------------SLSENAEE------------LLIEELKR 462
            ...|.......|.|..:|                   |.|||||.            .|.:..|.
Zfish   212 PAGAPGNMSTRDCAYGSITSPTSTLESRDSGIIATLTSYSENAEHGGKHSEGSRGSLKLWQAQKS 276

  Fly   463 GASECDTKELDNFQSQRTSTVNKAARTTLTRQQSEPA---PLQAMDAVNSDEKTGSNYGTHPPKR 524
            ..::.....:|...:..|.::||....:|....|..|   ||..|...||...|.|.:
Zfish   277 MGTDSFLYRVDENMAASTYSLNKIPERSLEHSVSHSAHSIPLYLMPRPNSVAATSSAH------- 334

  Fly   525 ASRERGDTEQDKDMGSEKEQKQSQEPKETPKSSPAKSKSKIPVKRGRSGSGVLSPSKLATISNGG 589
                      .:|:....||:|          :|.::..::|  |..|||           |..|
Zfish   335 ----------LEDLAYLDEQRQ----------APLRTSLRMP--RQNSGS-----------SRTG 366

  Fly   590 QSIQQGGGEDIADLNTDQEKHE-IEAAIKDDKVEEPQANNEDKKEDKPEADKELNDQLKEELD-- 651
            |          ||:......:. .:.|:|....|.|...        |:|.....:.|.:|:|
Zfish   367 Q----------ADMRVRFAPYRPPDIALKPLLFEVPSLT--------PDAVFTGREWLFQEVDMC 413

  Fly   652 -KSSQEPKEEETKEEATADSSAEPLID-FTESNVNGKQ------EEPQLKP----PVPGEKPRIS 704
             :||:....:..............:|. ....:.:|.:      :.|...|    .:|..:|:.:
Zfish   414 LRSSESTTSQGVIIVGNVGFGKTAIISRLVALSCHGNRMRQITSDSPHASPKHGDTLPLSQPQSA 478

  Fly   705 TNTLP-----PPLPKTKS----------------------------------------CRTIIAD 724
            ..||.     |..|:.:.                                        ||.....
Zfish   479 HGTLVGGSSCPGTPEMRRRQEEALRRLAAQVVAYHYCQSDNAYTCLVPEFVHNVAALLCRAPQMQ 543

  Fly   725 GYYELLLSNPEILECLSVDNIEKNPDECFKKAFLFPLLELTPPKTA-----LLLLIDSIDENYIN 784
            .|.:|||..|.:...||:....::|...|::..|.||..|...:..     |::|||.::|...:
Zfish   544 AYRDLLLRQPHLQSTLSLRACVQDPFNAFRRGLLEPLEILHRERKIACEENLIILIDGLNEAEFH 608

  Fly   785 EGNLISTLKGGRGTVTNHKSRNVAELLSNHIHLFPKWLFLVCTTKKQTKQITKMFTGFKKITLDD 849
            :.:...|               :...|...|..||.||.||.|.:...:.:|:... |.:|:||.
Zfish   609 KPDYGET---------------IVSFLCKTIERFPPWLKLVVTVRTTLQDVTRPLP-FHRISLDR 657

  Fly   850 LRKSHVV-KDVQEYIINRLNS--DFKDSIMLTKEIIE------SLHQLYIKSNGCILYLEKVLHG 905
            |.:|..: .|:|.||::||::  :.::::.|..::..      |.| |...|.|..|||:..|..
Zfish   658 LEESDAIDSDLQGYILHRLHASQEIQNNVALNGKLDNTAFTKLSAH-LKSLSRGSYLYLKLTLDL 721

  Fly   906 IKDNFFSFR--EIKLIPCTLNGLYLYICQKSF-NKKQYMKIRPLLNVLLAS---------SGYVD 958
            |:..:...:  ..|::|..|..:||......| .:..:.::.|||||.:||         .|.|
Zfish   722 IEKGYLVLKSSSYKVVPVNLAEVYLLQLNMRFPTQSSFERVLPLLNVAVASLHPLTDEQAYGAV- 785

  Fly   959 KLFLFNCLRTHNYTIDCQEFEKRLQLMRNILAYDSNAQRLKIFHNSFADWLVDVKFATK-KFICD 1022
                 |.......:::.::|::|.:|:...|....:..|:.| |.||.:||:..:...| ||:||
Zfish   786 -----NAGMMRGASMEWEDFQQRSELLSPFLVKRRDGTRMFI-HPSFREWLIWREDGEKTKFLCD 844

  Fly  1023 VNEGHVMISMYYLLVADTLCANTVRRFAYHLIRSGEYLTSRHVDLDLILMLLESRLNLSDCFYTN 1087
            ...||.:::.::......|.........:|::::
Zfish   845 PRSGHTLLAFWFSRQDSKLNRQQTLELGHHILKA------------------------------- 878

  Fly  1088 QMNCCAQCEHDFKYDVNFLPKTRAMLERFLASELSEPFAQFLC---DFFKPSLPTDAKMLKLLIE 1149
                     |.||.....:..:.::|:....|..:|..:..|.   :.:.|::    |:.:|||.
Zfish   879 ---------HIFKGLSKKVGVSSSVLQGLWVSYSTEGLSTALASLRNLYTPNV----KVSRLLIM 930

  Fly  1150 TGINNAESQNSCESSLMSPELSEKSQNIDFELADLLLSSEKSCLMETQRAGSPSEHSEPPAESQD 1214
            .|.|
Zfish   931 GGAN------------------------------------------------------------- 934

  Fly  1215 ENASSTLHQLSDSHHIELHKGKALIHILANDGNHQLLERALNACKSPIDLEIEDYNGQTALNIAA 1279
                                                           ::...|..|....|.:.|
Zfish   935 -----------------------------------------------VNYRTEVLNNAPILCVHA 952

  Fly  1280 RNGHLEVVKLLLSFSQPCNDGTGRMKRVDVNHADRDGWTPLRSASWGGHSEVVRLLIAQPACKID 1344
            ..|:||...|||.|.            .||:.....|.|||..|:..||..:|..|.::.| |:|
Zfish   953 HLGYLETAALLLEFG------------ADVDGVSESGLTPLGYAAAAGHLSIVTALCSKKA-KVD 1004

  Fly  1345 LADKEGRTALRAAAWSGHEDILKLLIE-----SGADVNSVDRQG--RTSLIAASYMGHYDIVEIL 1402
            ..||.|:.||..||..||.:::|.|::     .|..|.|..:..  :.:||||:.||:.:||..|
Zfish  1005 HLDKNGQCALVHAALRGHLEVVKYLVQCEWNTDGQQVGSFSKSHAIQQALIAAASMGYTEIVSYL 1069

  Fly  1403 L---------ENGANVNHLD-LDGRSALCVAALCGSSGYSKVISTLLDHGANTDQLDNDGMSPLL 1457
            |         |..|.:|:.| |.|.:||..||   ..|...|...||:.||...|.:..|:.||.
Zfish  1070 LDLPEKDEEEEERAQINNFDTLWGETALTAAA---GRGKLDVCRLLLEQGAAVAQPNRRGIVPLF 1131

  Fly  1458 VSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACTAGHATVVKLLLFWGCGIDCMDSEGRTVL 1522
            .:..:|:.::.:|||.:.||.::||..|||||..|.:.||....:.||..|..:..||.||.|.|
Zfish  1132 SAVRQGHWQIVDLLLNHGADVNMADKQGRTPLMMAASEGHLGTAEFLLAQGASLSLMDKEGLTAL 1196

  Fly  1523 SIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYAAFEGFHEVCLQLLESGAKIDECDNEGKTA 1587
            |....:|::..||.|::||....|.|.:|.|||..|||.|..||...|::.||.|:..|..|...
Zfish  1197 SWACLKGHLPLVRALVERGAATAHADKSGRTPLDLAAFYGDSEVVQFLVDHGAMIEHVDYSGMRP 1261

  Fly  1588 LHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACLEGHMDTVEFLLKFCCDVNSKDADSR 1652
            |..|........|.|||              |...::.|                  .:....:|
Zfish  1262 LDRAVGCRNTSVVVALL--------------KKGAKIGC------------------QTLPTRAR 1294

  Fly  1653 TTLYILALENKLEIVKYLLDMTNVDVNIPDSEG--------------RTALHVAAWQGHADMVKT 1703
            .........:|.:|:..||...     |.:.:|              :.||.....:|..:.:||
Zfish  1295 GPATWAMATSKPDIMIVLLSKL-----IEEGDGFYKKGKVKEAAQRYQYALKKFPREGFTEDLKT 1354

  Fly  1704 LIEAGADVNSMDLEARTPLHSCAWQGNHDVMNILLYYGALADHACKQGATALGISAQEGHEKCVI 1768
            ..|....:                     ::|:         ..|::.....|: |:|...|.
Zfish  1355 FRELKVSL---------------------LLNL---------SRCRRKMNDFGM-AEEFASKA-- 1386

  Fly  1769 ALLQFGANPYKSDHCGRTPIKLAAKSSRTSILKIFESY------------------------TKN 1809
              |:.....|:: :..|...|.:::....::..:.|:.                        .:.
Zfish  1387 --LELKPKSYEA-YYARARAKRSSRQFHAALEDLSEAVRLCPNNREIQRLLQRVEEECRQVEQQQ 1448

  Fly  1810 EASNPNEPKFHAHASMLRSPDQ---------------------------------------PPAL 1835
            |...|..|......||:..|..                                       |..|
Zfish  1449 ELDPPPSPPREQAPSMVPPPPMEPHISDMEPVQDLFEEDDDYLERDLDGLPLGVAAETHIIPSGL 1513

  Fly  1836 PLHQNLAPYPAH-------------ASASSVCS---------AATTATVHNGSHLHVLNASSSTH 1878
            |:.||:.|.|:|             .|..|:.|         :.:.:..|..||   ...|....
Zfish  1514 PVIQNMPPSPSHHESPYLGQTYDLRPSPPSMSSPTRQGYQSTSPSLSPTHQSSH---FRPSPPHQ 1575

  Fly  1879 SSNNF------------YQNTMQSDTSSLHKRKSVIS---SQSTGSSNDQAPLT---------FT 1919
            :|.:|            |:::..|:.:::::.:|..:   .|...:...::||:         |:
Zfish  1576 ASYHFSPPPSPLRRGPQYRSSPTSEAAAMYRPQSASAGRYQQDPLAGRPKSPLSKMSSQRSFQFS 1640

  Fly  1920 QQLQRQSKLSS----------RNNLMVNSKHASS------------------------SGAAGHK 1950
            ||..:.::.|.          |.|....:.|:|:                        .|..|:.
Zfish  1641 QQPSQPAQQSQWLQPAKAQIVRTNQPSTAVHSSAVLGSSAYSQIAHSMSARCPGDMDELGDGGYS 1705

  Fly  1951 SS-------GGGGGAQRHSQVLPDLSEHQLASNMTN------------EADMYDMECMSPLYATP 1996
            ||       ..|...||...:.|.|.|.:|....::            :.........:..|..|
Zfish  1706 SSLQPQGSLSAGALYQRAISMDPGLMEDELPQRPSSAYRPTPGGVRYGQTPQISRSQSTAYYPVP 1770

  Fly  1997 PHSPSSE--LSSPGQLPGLNAFVDDERAGTSSGGGAKLPDNHFARDTHMRIILGNLKENQPSSSG 2059
            ||....:  |.||..|......|....|..........|..| :..|.:|.        .||::.
Zfish  1771 PHEMERQVTLGSPENLHAHRRPVSANSAEPKQHPPGPRPLIH-SHSTGLRF--------SPSTNS 1826

  Fly  2060 KSKRSGVSSNPAMR 2073
            ....|..:..|..|
Zfish  1827 LGPASAANLGPGFR 1840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	ANKYR	1236..1489	CDD:440430	80/269 (30%)
		ANK repeat	1270..1313	CDD:293786	12/42 (29%)
		ANK repeat	1315..1347	CDD:293786	12/31 (39%)
		ANK repeat	1349..1380	CDD:293786	12/35 (34%)
		ANK repeat	1382..1413	CDD:293786	13/41 (32%)
		ANK repeat	1415..1446	CDD:293786	11/30 (37%)
		ANKYR	1469..1788	CDD:440430	79/332 (24%)
		ANK repeat	1484..1515	CDD:293786	11/30 (37%)
		ANK repeat	1517..1548	CDD:293786	12/30 (40%)
		ANK repeat	1550..1581	CDD:293786	14/30 (47%)
		ANK repeat	1617..1648	CDD:293786	2/30 (7%)
		ANK repeat	1650..1682	CDD:293786	6/31 (19%)
		ANK repeat	1684..1715	CDD:293786	7/44 (16%)
		ANK repeat	1717..1742	CDD:293786	1/24 (4%)
		ANK repeat	1750..1775	CDD:293786	5/24 (21%)
tanc2a	XP_068075010.1	PHA03095	915..>1214	CDD:222980	106/426 (25%)
		ANK repeat	948..974	CDD:293786	11/37 (30%)
		ANK repeat	976..1007	CDD:293786	12/31 (39%)
		ANKYR	<1086..1284	CDD:440430	75/214 (35%)
		ANK repeat	1093..1123	CDD:293786	12/32 (38%)
		ANK repeat	1125..1156	CDD:293786	9/30 (30%)
		ANK repeat	1159..1189	CDD:293786	11/29 (38%)
		ANK repeat	1191..1222	CDD:293786	12/30 (40%)
		ANK repeat	1224..1255	CDD:293786	14/30 (47%)
		ANK repeat	1257..1287	CDD:293786	9/61 (15%)
		TPR repeat	1316..1341	CDD:276809	3/29 (10%)
		TPR	1323..>1452	CDD:440225	18/164 (11%)
		TPR repeat	1346..1389	CDD:276809	11/77 (14%)
		TPR repeat	1394..1422	CDD:276809	4/28 (14%)
		PHA03247	<1451..1851	CDD:223021	66/402 (16%)