DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10011 and ankhd1

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	XP_009293757.1	Gene:	ankhd1 / 563327	ZFINID:	ZDB-GENE-090421-1	Length:	2607	Species:	Danio rerio

Alignment Length:	1077	Identity:	262/1077 - (24%)
Similarity:	420/1077 - (38%)	Gaps:	190/1077 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1139 TDAKMLKLLIETGINNAESQNSCESSLMSPELSE-KSQNIDFE-LADLLLSSEKSCLMETQRAGS 1201
            ||....||.....:::.....|.|.     |:|| :|..:|.| |.:.:|.:....|:.:...|:
Zfish    64 TDRLDFKLTAAAVLSSGPGSGSDED-----EVSEVESFILDQEDLDNPVLKTASELLLSSAADGA 123

  Fly  1202 PSEHSEPPAESQDENASSTLHQLSDSHHIELHKGKALIHILANDGNHQLLERALNACKSPID--- 1263
            .....:|..:::.|    .|.:.:....:....|||.       .:.::|.|..::....:|
Zfish   124 DLRTVDPETQARLE----ALLEAAGIGKLSTADGKAF-------ADPEVLRRLTSSVSCALDEAA 177

  Fly  1264 LEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPCNDG----------TGRMKRVDVNHADRDGWT 1318
            ..:.....:..||.:..:   .:|....|.::.|:||          .||    .||....:|.:
Zfish   178 AALTRMRAENTLNASQAD---NLVIFSRSLAEACSDGDVNAVRKLLDEGR----SVNEHTEEGES 235

  Fly  1319 PLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLIESGADVNSVDRQG 1383
            .|..|...|:.|:.::|:|..|...|...|...|.|.|||..|:.||:|||:..|||||:....|
Zfish   236 LLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAASGGYVDIVKLLLVHGADVNAQSSTG 300

  Fly  1384 RTSLIAASYMGHYDIVEILLENGANVNHLDLDGRSALCVAALCGSSGYSKVISTLLDHGANTDQL 1448
            .|:|..|...|..|:|::||:.|||:...:.:|.:.|..||   |:|:.:|...||::||..:..
Zfish   301 NTALTYACAGGFLDVVKVLLKEGANIEDHNENGHTPLMEAA---SAGHVEVARVLLEYGAGINTH 362

  Fly  1449 DND-GMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACTAGHATVVKLLLFWGCGID 1512
            .|: ..|.|.::.::|:.::...|||..||.:.......|.|..||..||..|.:|||..|..::
Zfish   363 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 427

  Fly  1513 CMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYAAFEGFHEVCLQLLESGAKI 1577
            .......:.|::.|..|:||....|::||.:....::.|:|||..||.||..|:...||..||.|
Zfish   428 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 492

  Fly  1578 DECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACLEGHMDTVEFLLKFCC 1642
            :....|        .||                         ||..|||..|.::..:||:|...
Zfish   493 NAQTEE--------TQE-------------------------TALTLACCGGFLEVADFLIKAGA 524

  Fly  1643 DVNSKDADSRTTLYILALENKLEIVKYLLDMTNVDVNIPDSEGRTALHVAAWQGHADMVKTLIEA 1707
            |:   :....|.|...|.|..||:||||| ....:|:...:.|.|||..|...||.|:...|::.
Zfish   525 DI---ELGCSTPLMEAAQEGHLELVKYLL-AAGANVHATTATGDTALTYACENGHTDVADVLLQT 585

  Fly  1708 GADVNSMDLEARTPLHSCAWQGNHDVMNILLYYGALADHA-CKQGATALGISAQEGHEKCVIALL 1771
            |||:.......||||...|..|:...:..|:..||..:.| .....|.:.::...||...|..||
Zfish   586 GADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLL 650

  Fly  1772 QFGANPYKSDHCGRTPIKLAAKSSRTSILKIFESYTKNEASNP---------------NEPK--F 1819
            ..||:|......|.|.:..|||...|:::.....|..|..|.|               ..|:  |
Zfish   651 AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNILSVPAPDLSQLTPPSHDTSQAPRVPF 715

  Fly  1820 HAHASMLRSPDQPPALP--------------LHQNLAPYPAHASASSVCSAATTATVHNGSHLHV 1870
            .|.| |:..|.:|..:|              ..|.|:...:::.||....|......|....|..
Zfish   716 QALA-MVVPPQEPDRVPSTIPTPPPVTSKGASKQRLSSLQSNSVASGGLDADLLPPFHPYQPLEC 779

  Fly  1871 LNASSSTHSSNNFYQNTMQSDTSSLHKRKSVISSQSTGSSNDQAPLTFTQQLQRQSK-------- 1927
            : ...:....|...|.....:.:.|...:.:.....|....::...:..:|:|::.|
Zfish   780 I-VEETEGKLNELGQRISAIEKAQLQSLELIQGEPLTKDKIEELKKSREEQVQKKKKILKELQKV 843

  Fly  1928 ---LSSRNNLMVNSKHASSSGAAGHKSSGGGGGAQRHSQVLPDLSEHQLASN------------- 1976
               |..:.......::..:.|.  .:..|...|.:.....|| |...||.|:
Zfish   844 ERQLQLKTQQQFTKEYMETKGL--KEELGQAAGVEMPGTPLP-LQATQLGSDNECEGIHEKEDHR 905

  Fly  1977 --MTN------EADMYDMECM------SPLYATPPHSPSSEL--SSPGQ---------LPGLNA- 2015
              .||      |.|..|::|.      :.|...||..|.:::  |.|.|         .|.|:.
Zfish   906 PTPTNEEDEDEEEDEDDIDCAKLPQVNTILQPPPPPPPQNQVLQSPPLQTSFVPIQPLTPQLSTD 970

  Fly  2016 FVDDERAGTSSGGGAKLPDNHFARDTHMRIILGN-LKENQPSSSGKSKRSGVSSNPAMRLIRSRF 2079
            |...|..|:||      ||       ..|::||. |....|....::....:.:.||..|.
Zfish   971 FSSAEYPGSSS------PD-------LQRVLLGQPLTGLGPGLLAQASDGLMVATPAQTLT---- 1018

  Fly  2080 DAASQLIRRTN------NILSSSSNQGSSSIGVKSGT 2110
            |....::...|      |..:|.|.|.|:...:.:.:
Zfish  1019 DTLDDIMAAVNSRVPVVNTTTSPSPQPSAQTPINTAS 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728
		Ank_4	1237..1291	CDD:290365	7/56 (13%)
		ANK	1266..1403	CDD:238125	44/146 (30%)
		ANK repeat	1270..1313	CDD:293786	11/52 (21%)
		Ank_2	1275..1380	CDD:289560	37/114 (32%)
		ANK repeat	1315..1347	CDD:293786	9/31 (29%)
		ANK repeat	1349..1380	CDD:293786	16/30 (53%)
		Ank_2	1354..1449	CDD:289560	38/94 (40%)
		ANK repeat	1382..1413	CDD:293786	12/30 (40%)
		ANK	1410..1538	CDD:238125	36/128 (28%)
		ANK repeat	1415..1446	CDD:293786	11/30 (37%)
		Ank_5	1438..1489	CDD:290568	14/51 (27%)
		ANK	1479..1604	CDD:238125	36/124 (29%)
		ANK repeat	1484..1515	CDD:293786	11/30 (37%)
		Ank_2	1489..1581	CDD:289560	32/91 (35%)
		ANK repeat	1517..1548	CDD:293786	8/30 (27%)
		ANK repeat	1550..1581	CDD:293786	14/30 (47%)
		Ank_2	1555..1648	CDD:289560	24/92 (26%)
		ANK	1578..1705	CDD:238125	33/126 (26%)
		ANK repeat	1617..1648	CDD:293786	10/30 (33%)
		Ank_2	1624..1715	CDD:289560	32/90 (36%)
		ANK	1645..1771	CDD:238125	38/126 (30%)
		ANK repeat	1650..1682	CDD:293786	12/31 (39%)
		ANK repeat	1684..1715	CDD:293786	12/30 (40%)
		Ank_2	1689..1781	CDD:289560	28/92 (30%)
		ANK repeat	1717..1742	CDD:293786	7/24 (29%)
		ANK repeat	1750..1775	CDD:293786	6/24 (25%)
ankhd1	XP_009293757.1	Ank_2	204..296	CDD:289560	33/95 (35%)
		ANK repeat	204..230	CDD:293786	7/29 (24%)
		ANK	227..353	CDD:238125	46/128 (36%)
		ANK repeat	232..264	CDD:293786	9/31 (29%)
		ANK repeat	269..297	CDD:293786	16/27 (59%)
		Ank_2	271..360	CDD:289560	38/91 (42%)
		ANK	294..420	CDD:238125	41/128 (32%)
		ANK repeat	299..330	CDD:293786	12/30 (40%)
		ANK repeat	332..360	CDD:293786	11/30 (37%)
		ANK	362..486	CDD:238125	37/123 (30%)
		ANK repeat	366..397	CDD:293786	8/30 (27%)
		Ank_4	369..420	CDD:290365	16/50 (32%)
		ANK repeat	401..430	CDD:293786	11/28 (39%)
		Ank_2	404..495	CDD:289560	32/90 (36%)
		ANK repeat	432..463	CDD:293786	8/30 (27%)
		ANK repeat	465..495	CDD:293786	14/29 (48%)
		ANK repeat	498..527	CDD:293786	13/64 (20%)
		Ank_4	502..550	CDD:290365	19/50 (38%)
		ANK	532..650	CDD:238125	38/118 (32%)
		ANK repeat	532..560	CDD:293786	12/28 (43%)
		Ank_2	534..624	CDD:289560	32/90 (36%)
		ANK repeat	562..593	CDD:293786	12/30 (40%)
		ANK repeat	595..624	CDD:293786	9/28 (32%)
		Ank_2	600..689	CDD:289560	23/88 (26%)
		ANK	625..>702	CDD:238125	20/76 (26%)
		ANK repeat	629..659	CDD:293786	9/29 (31%)
		Prefoldin	<816..854	CDD:298833	4/37 (11%)
		ANK	1075..1103	CDD:197603
		ANK repeat	1077..1106	CDD:293786
		Ank_2	1080..1173	CDD:289560
		ANK	1104..1231	CDD:238125
		ANK repeat	1108..1140	CDD:293786
		ANK repeat	1142..1173	CDD:293786
		Ank_2	1147..1240	CDD:289560
		ANK repeat	1175..1206	CDD:293786
		ANK repeat	1210..1240	CDD:293786
		Ank_2	1215..1306	CDD:289560
		ANK repeat	1243..1275	CDD:293786
		ANK	1273..1399	CDD:238125
		ANK repeat	1277..1306	CDD:293786
		Ank_2	1282..1376	CDD:289560
		ANK repeat	1314..1343	CDD:293786
		ANK repeat	1345..1376	CDD:293786
		KH-I	1736..1798	CDD:238053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920