DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10011 and CG42534

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster

Alignment Length:	1054	Identity:	221/1054 - (20%)
Similarity:	380/1054 - (36%)	Gaps:	268/1054 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1168 PELSEKSQNIDFELADLLLSSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHIEL 1232
            |.|....:.:.||       |.......|.:.....::..||.:.:.|....           :.
  Fly    19 PRLKAAKKQLQFE-------SPLPRRTRTMQQQQQQDNDHPPQQEKQEQQQQ-----------QQ 65

  Fly  1233 HKGKALIHILANDGNHQLLERALNAC-------KSPIDLEIED------------YNGQTALNIA 1278
            .:.:|...::|..|:.|..:.|..|.       ..|..|.:..            ..|.|:|..|
  Fly    66 QRQEAADKVIAMPGSSQDTDAAAEAAVDVPETDPDPAQLTVSQSQSSSTVARRRLAEGCTSLMYA 130

  Fly  1279 ARNGHLEVVKLLLSFSQPCNDGTGRMKRVDVNH---------ADRDGWTPLRSASWGGHSEVVRL 1334
            .:.|  ::|::|...    .:....:::.|.:|         .|.:|...|.:|:        .:
  Fly   131 CQRG--DIVQVLAQM----REKPELLRQRDRSHRNALHYCAAQDSEGSKDLVAAA--------SI 181

  Fly  1335 LIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLIESGADVNSVDRQGRTSLIAASYMGHYDIV 1399
            .||.|.. ::.||::|.|.|..|...|:..::.||:.:.||||:||.:|.:.:..|:..|..:.:
  Fly   182 AIAAPEL-LESADEDGFTPLHLAVIQGNLAMVNLLLANKADVNAVDNEGHSVVHWATVCGEVESL 245

  Fly  1400 EILLENGANVNHLDLDGRSALCVAA-LCGSSGYSKVISTLLDHGANTDQLDNDGMSPLLVSSFEG 1463
            ..:|..||:|...|.:|.:.|..|| :||:   ||..|......:|:.:|
  Fly   246 RAVLAAGASVAKPDANGGTPLHYAAQMCGA---SKQDSKQQASSSNSSRL--------------- 292

  Fly  1464 NAEVCELLLEN-AADPDLADFMGRTPLWAACTAGHATVVKLLLFWGCGIDCMDSEGRTVLSIGAA 1527
            :.|:..:||.: .:..|:.|..||.||..|.:||.|..|..|:..|..::..|.:|.|.|....:
  Fly   293 SLEILGILLSHPQSSVDVQDKDGRQPLLWAASAGSAKAVIALVKAGARVESSDKDGLTALHCAGS 357

  Fly  1528 QGNVETVRQLLDRGLDETHRDNAGWTPLHYAAFEGFHEVCLQLLESGAKIDECDNEGKTALHLAA 1592
            :|:.|.:..|:  ||                        |      ||..|..|:.|.||||.|.
  Fly   358 RGHTECIDTLI--GL------------------------C------GAPTDLIDSNGCTALHYAV 390

  Fly  1593 QEGRLHCVQALLDIHSSFVDQKAHD--GKTAFRLACLEGHMDTVEFLLKFCCDVNSKDADSRTTL 1655
            ..|.......|||:.:   |....|  |:|.....|.:|..:|::.|.:...::..::|.....|
  Fly   391 TLGHADATARLLDLEA---DPNRQDRKGRTPAHCGCSKGQFETLKLLKERGANLWLRNAKGDLPL 452

  Fly  1656 YILALENKLEIVKYLLDMTNVDVNIPDSEGRTALHVAAWQGHADMVKTLIEAGADVNSMDLEAR- 1719
            :..|...:.|::::||......||...::||:.||:||...:.||.|.|::.|||||::...:|
  Fly   453 HEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAANDYTDMCKLLLDYGADVNAVYRNSRG 517

  Fly  1720 ---TPLHSCAWQGNHDVMNILLYYGALADHACKQGATALGISAQEGHEKCVIALLQFGANPYKSD 1781
               |||.....:|:......|...|.       |.|..:.:|::.            ..||:...
  Fly   518 LVLTPLDGALQRGHRSTAKFLQANGG-------QPANKVRLSSRR------------TGNPFHET 563

  Fly  1782 HCGR--TPIKLAAKSS----RTSILKIFESYTK-NEASNPNEP---------------------- 1817
            :...  .|:|...|..    |:|  |.:..|.| :::.|.||.
  Fly   564 NATDMVRPLKYVEKEELHDLRSS--KKYVVYLKRSDSDNGNENGKADVGDGDCSCSEQTYRKEQR 626

  Fly  1818 -----KFHAHASMLRSPDQPPALPLHQNLAPYPAHASASSVCSAATTATVHNGSHLHVLNASSST 1877
                 :.|....:.|          ..:......|...|.:|.:.:...:..       ..|...
  Fly   627 LRHVCRRHKRRQLRR----------RTSSCGESKHERCSEICRSKSNIEIRR-------RKSRER 674

  Fly  1878 HSSNNFYQNTMQSDTSS---LHKRKS---VISSQSTGS-------SNDQAPLTFTQQLQRQSKLS 1929
            ::|::.::.....|:..   .|||:.   |...:||.|       |:|......::......| .
  Fly   675 YASSSEWEEESAEDSCENCCYHKRQKDRVVNRKRSTSSRKSKNRDSSDPDEKNHSENHSSPEK-G 738

  Fly  1930 SRNNLMVNSKHASSSGAAGHKSSGGGGGAQRHSQVLPDLSEHQLASNMTNEADMYDMECMSPLYA 1994
            ||..|.||..|.:.:|.....:          .:..|..|.||
  Fly   739 SRKPLAVNGDHQADNGKDQTST----------KERPPSASRHQ---------------------- 771

  Fly  1995 TPPHSPSSELSSP---------GQLPGLNAFVD--------DERAGTSSGGGAKLPDNHFARDTH 2042
            |||....:.:.||         ||:.  |..|:        ||....:.....::..:|.|.:
  Fly   772 TPPTKEGTFIKSPTQSAKSEKSGQMD--NLLVEESHAVELTDEEQEAAKSVVTQVDVHHDAEE-- 832

  Fly  2043 MRIILGNLKENQPSS--SGKSKRSGVSSNPAMRLIRSRFDAASQLIRRTNNILSSS-SNQGSSSI 2104
              |......|..|.:  :||.|.|  .....::|........|:.:.:...|.::: |::..||.
  Fly   833 --IQTSKSSEEAPQAEENGKEKES--EQEVKLQLSEEETQLVSKEVEQVIIIAATALSSESKSSS 893

  Fly  2105 GVKSGTFQWRKESQ 2118
            ..||...:..||.|
  Fly   894 EEKSVEKELPKEGQ 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728
		Ank_4	1237..1291	CDD:290365	14/72 (19%)
		ANK	1266..1403	CDD:238125	34/157 (22%)
		ANK repeat	1270..1313	CDD:293786	9/51 (18%)
		Ank_2	1275..1380	CDD:289560	27/113 (24%)
		ANK repeat	1315..1347	CDD:293786	6/31 (19%)
		ANK repeat	1349..1380	CDD:293786	11/30 (37%)
		Ank_2	1354..1449	CDD:289560	29/95 (31%)
		ANK repeat	1382..1413	CDD:293786	7/30 (23%)
		ANK	1410..1538	CDD:238125	34/129 (26%)
		ANK repeat	1415..1446	CDD:293786	10/31 (32%)
		Ank_5	1438..1489	CDD:290568	9/51 (18%)
		ANK	1479..1604	CDD:238125	34/124 (27%)
		ANK repeat	1484..1515	CDD:293786	11/30 (37%)
		Ank_2	1489..1581	CDD:289560	21/91 (23%)
		ANK repeat	1517..1548	CDD:293786	8/30 (27%)
		ANK repeat	1550..1581	CDD:293786	4/30 (13%)
		Ank_2	1555..1648	CDD:289560	23/94 (24%)
		ANK	1578..1705	CDD:238125	37/128 (29%)
		ANK repeat	1617..1648	CDD:293786	7/32 (22%)
		Ank_2	1624..1715	CDD:289560	27/90 (30%)
		ANK	1645..1771	CDD:238125	33/129 (26%)
		ANK repeat	1650..1682	CDD:293786	7/31 (23%)
		ANK repeat	1684..1715	CDD:293786	15/30 (50%)
		Ank_2	1689..1781	CDD:289560	25/95 (26%)
		ANK repeat	1717..1742	CDD:293786	6/28 (21%)
		ANK repeat	1750..1775	CDD:293786	3/24 (13%)
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	27/113 (24%)
		ANK	193..335	CDD:238125	47/159 (30%)
		ANK repeat	195..226	CDD:293786	11/30 (37%)
		Ank_5	214..269	CDD:290568	18/54 (33%)
		ANK repeat	228..259	CDD:293786	7/30 (23%)
		ANK repeat	314..345	CDD:293786	11/30 (37%)
		Ank_2	319..412	CDD:289560	33/127 (26%)
		ANK	345..468	CDD:238125	36/157 (23%)
		ANK repeat	347..379	CDD:293786	12/63 (19%)
		ANK repeat	381..412	CDD:293786	11/33 (33%)
		ANK	409..538	CDD:238125	35/128 (27%)
		ANK repeat	414..479	CDD:293786	14/64 (22%)
		ANK repeat	419..445	CDD:293786	4/25 (16%)
		Ank_2	420..511	CDD:289560	27/90 (30%)
		ANK repeat	481..511	CDD:293786	15/29 (52%)
		Ank_2	486..>545	CDD:289560	20/65 (31%)
		ANK repeat	516..542	CDD:293786	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12834at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010