DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10011 and rols

DIOPT Version :10

Sequence 1:NP_651624.2 Gene:CG10011 / 43387 FlyBaseID:FBgn0039590 Length:2119 Species:Drosophila melanogaster
Sequence 2:NP_729778.1 Gene:rols / 39368 FlyBaseID:FBgn0041096 Length:1900 Species:Drosophila melanogaster


Alignment Length:1909 Identity:407/1909 - (21%)
Similarity:644/1909 - (33%) Gaps:521/1909 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 SVRKMQQQKSSTQTVSSNHNPNANSIGNCDSTSVINKNHPPPVNNMPKEM----LYATPLRKSDR 87
            ||..|.....|:..||      |...|:...:.|::.....|...:.:||    |.|.   :||.
  Fly   256 SVPPMDLSMISSDGVS------ALDWGSASVSCVLDSGDGNPAEELNEEMAAKCLSAA---ESDL 311

  Fly    88 YKSGDRTRHVATGNA------------ETKLFNFRDSNRLASA--RNGN-PVQVTDLDADEDDAQ 137
            ........|.|:|:.            ..||.:.....|..|.  ||.. |:.:.....|.|.|.
  Fly   312 QSIRRLLEHDASGSVCPSCRISFDKGKRRKLIDTCGHERCYSCMFRNDQCPMCMNSSLKDVDGAN 376

  Fly   138 GDGVD-GCGSTSALVGGSKYSSQPSAGTANQHLEDRRILNFLKDTTQLQKKLEITGRDCPNASFS 201
            ..|.| |.|.:::.:.....|.||...:..|  .:..:..:::...|..:..:...|...|....
  Fly   377 AQGYDTGIGGSTSTIVSPLGSPQPQLRSHAQ--RNAALARYMQQHRQESQSPDYHHRYASNGKLP 439

  Fly   202 NLA----REEHFANLVQQNFPQDVAHHANGETNGGSAPEEDGQEAAGGLK--------------- 247
            ..|    ....|.....|....||.|...|  .||.|.....|..|.|:.               
  Fly   440 RAAALSTNGNGFTTGTTQTVTVDVHHQLGG--GGGGAAAAAKQLMANGISGHSRSSSMSHNIHAA 502

  Fly   248 -------------TQPTED---TDGNLEALMQRKVSPDKEVNGLVHSA-GVEPNNR--------- 286
                         |.||..   ...||.:.:.........|.|.|..| ||...:|         
  Fly   503 AYSELSAAPPAFATPPTRRRFFNHKNLRSALTGGSGGGSGVGGGVGGAGGVGGGHRRTASNGGCP 567

  Fly   287 -----IVSTVYIHREWVLKKIALCLEQRTAGKKSGPVALGGAASSSYVSARAKAAAISSSSYNGC 346
                 |:|..:.|:..       ..:.:..||:|..:.....:.|:....|.|..          
  Fly   568 IDTASILSGDHTHQHH-------HRDNQPEGKESNALNTSTCSDSAVTRRRRKNV---------- 615

  Fly   347 LVLGSNGSGKTSICQAIMKGNSGTKGILNRKLLACYLIESQNPECHSLSLFMRKIVLQLLSHASL 411
                ||.:.|||     .:..:.::..|||..||...:.:.    |..||...||    .|..|:
  Fly   616 ----SNHNLKTS-----ARHGASSENRLNRLSLAGTSVYAG----HLSSLVFGKI----KSLWSV 663

  Fly   412 ISRDESQR---------IIDEGFSFLRDEAQQQEF--KLDEAMNNISLSENAEELLIEELKRGAS 465
            .|.:.|:.         .||...|||.::.|:.:.  :|...:|:...:.|:..        ..|
  Fly   664 NSSNSSEAGLNQLAGSDAIDHHSSFLNEKLQKDQLHARLGLLLNDPGSNGNSSS--------SGS 720

  Fly   466 ECDTKELDNFQSQRTSTVNKAARTTLTRQQSEPAPLQAMDAVNSDEKTGSNYGTHPPKRASRERG 530
            .|:.....:..|..:|:...||.||                     .:||:....|.:..:...|
  Fly   721 GCEPISAHSTTSTTSSSGVGAASTT---------------------TSGSSQNVSPEQTLASGAG 764

  Fly   531 DTEQDKDMGSEKEQKQSQEPKETPKSSPAKSKS---------KIPVKRGRSGSGVLSPSKLATIS 586
            ...     ||:.....|...||...|...|.|:         .:|.| .|.|:     .:.:|..
  Fly   765 MLS-----GSQLSVATSHGVKEDALSLCGKFKAGCSMLHVYEALPSK-SRKGN-----VRRSTRG 818

  Fly   587 NGGQSIQQGGGEDIADLNTDQEKHEIEAAIKDDKVEEPQANNEDKKEDKPEADKE-LNDQLKEEL 650
            ..|.|........:....|......::.|:|....|.|.     ::.|.|...:: |..||...|
  Fly   819 QQGSSSSASAASAVGSRVTASSLAAVQLALKPLFFEVPL-----QEPDPPYVGRQWLVQQLSNIL 878

  Fly   651 DKSSQEPKEEETK------EEATADSS-AEPLIDFTESNVNGKQEEP-----QLKPPVPGEKPR- 702
                   ...||:      :..|..:: ...|::::.......|::|     ||:.....|:.| 
  Fly   879 -------LGTETRVVLINGQPGTGKTAFCLQLVEYSCFGRRQMQDDPDGIYSQLQLGAHCERMRG 936

  Fly   703 ISTN-----------TLPPPLP------KTKSCRTIIADGYYELLLSNPEILECLSVDNIEKNPD 750
            ::::           .|...:|      ..:.|:......|.:.|||.|.:.:.|||.....:.:
  Fly   937 LASHMVGYHFCQADANLTCQVPDFVHSLAAQLCQAPQLTAYRDYLLSEPHLQDILSVRECIADAE 1001

  Fly   751 ECFKKAFLFPLLEL-----TPPKTALLLLIDSIDENYINEGNLISTLKGGRGTVTNHKSRNVAEL 810
            ...|.|.|.||..|     .|.|.| ::::|::.|...:..:...|:......:|.|        
  Fly  1002 RVMKLAILEPLAHLHRAGKIPAKVA-VIVVDALCEAEYHRPDHGHTIASFLAQLTPH-------- 1057

  Fly   811 LSNHIHLFPKWLFLVCTTKKQTKQITKMFTGFKKITLDDLRKSHVV-KDVQEYIINRL------- 867
                   ||.||.||.|.:.|..::.|. ..:.::|||....|..: :|:.:||..||       
  Fly  1058 -------FPAWLKLVATVRTQMLELVKA-PSYTQLTLDSWASSQALQQDMLDYIGARLADSPEIR 1114

  Fly   868 ---------NSDFKDSIMLTKEIIESLHQLYIKSNGCILY----LEKVLHG---IKDNFFSFREI 916
                     ||. ..|...|| .:..|..|   |.|.:||    |:.:..|   ||.:.:     
  Fly  1115 MNIGGGGGQNSQ-SGSQPQTK-FVSHLQSL---SRGSMLYAKLILDLIARGQLVIKSSSY----- 1169

  Fly   917 KLIPCTLNGLYLYICQKSF-NKKQYMKIRPLLNVLLASSGY---VDKLFL-FNCLRTHNYTIDCQ 976
            |::|.:|..::|......| ..:.:.:..|:||:.||:. |   :|:::. ...|......:...
  Fly  1170 KVLPVSLAQIFLLHFNLRFPTARSFEQAAPILNICLAAL-YPLTLDEIYYSMEALSHGREALSWP 1233

  Fly   977 EFEKRLQLMRNILAYDSNAQRL----KIFHNSFADWLV--DVKFATKKFICDVNEGHVMISMYYL 1035
            :|.:|.:|:...|     .:||    ..||:|..:||:  | :..:.||:||...||..|:    
  Fly  1234 DFMQRFKLLDGFL-----IKRLDNTYMFFHSSLREWLMRRD-EGESNKFLCDARLGHAGIA---- 1288

  Fly  1036 LVADTLCANTVRRFAYHLIRSGEYLTSRHVDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFK 1100
                                                                             
  Fly  1289 ----------------------------------------------------------------- 1288

  Fly  1101 YDVNFLPKTRAMLERFLASELSEPFAQFLCDFFKPSLPTDAKMLKLLIETGINNAESQNSCESSL 1165
                           |..|.|..|.:..|      :|.....|||         |........:|
  Fly  1289 ---------------FRLSRLQAPLSPQL------TLELGHHMLK---------AHLYGGTSLTL 1323

  Fly  1166 MSPELSEKSQNIDFELADLLLSSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHI 1230
            :||.          :|....|            ||:.            :|.||:|..|.:.:..
  Fly  1324 LSPR----------DLQSYWL------------AGAA------------DNISSSLGALRNVYSP 1354

  Fly  1231 ELHKGKALIHILANDGNHQLLERALNACKSPIDLEIEDY-NGQTALNIAARNGHLEVVKLLLSFS 1294
            .| |...|:.:.....||:                 .|| .|...|.|||..|.|.:|.|||.|.
  Fly  1355 NL-KVSRLVLLAGASPNHR-----------------TDYMGGAPILCIAAHEGILPMVSLLLEFG 1401

  Fly  1295 QPCNDGTGRMKRVDVNHADRDGWTPLRSASWGGHSEVVRLLIAQPAC--KIDLADKEGRTALRAA 1357
                        .||...:..|.|||..|:..||.:|||.|:|..:.  ::|:..   |.||..|
  Fly  1402 ------------ADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQ---RCALVHA 1451

  Fly  1358 AWSGHEDILKLLI-------ESGADV-NSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDL 1414
            |..||..::|.|:       ....|| .||..|  .:||.|:...|..|:|.||:  .|....||
  Fly  1452 ARMGHLSVVKYLLACDWSPRPHSQDVTRSVALQ--QALIGAAAQAHCKILEDLLD--LNETEFDL 1512

  Fly  1415 D--------GRSALCVAALCGSSGYSKVISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELL 1471
            |        |..||..||   ..|...|:..||..||..|..:..|.|.|.::..||:..|.|.|
  Fly  1513 DVNGMEPSSGELALTAAA---RHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHL 1574

  Fly  1472 LENAA--DPDLADFMGRTPLWAACTAGHATVVKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETV 1534
            |:..|  |..|.. ..:|||..|...||..:|.|||..|...:..|.||.|.||....:|::...
  Fly  1575 LQRGALLDEPLGQ-TRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAA 1638

  Fly  1535 RQLLDRGLDETHRDNAGWTPLHYAAFEGFHEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHC 1599
            :.|::.|.:..|.|:.|.|.|..||::|...:.:.:||.|..::..|..|...|..|.....:..
  Fly  1639 KTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQA 1703

  Fly  1600 VQALL------------------DIHSSFVDQKAHDGKTAFRLACLEGHMDTVEFLLKFCCDV-- 1644
            ||..|                  :|....:::...||...:|....:......::.|:....:  
  Fly  1704 VQVFLRKGAKLGPTTWSMAMGKPEILVILLNKLLEDGNVLYRKNRFQEAAHRYQYALRKISGLEQ 1768

  Fly  1645 ----NSKDADSRTTLYILALENKLEIVKYLLDMTNVDVNIPDSEGRTALHVAAWQGHADMVKTLI 1705
                |:..|..||.|.       |.:.:....:..:|.:|..:....|....:::|:....|..:
  Fly  1769 LLERNAIFAQLRTNLL-------LNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKARM 1826

  Fly  1706 EAGADVNSMDLEARTPLHSCAWQG 1729
            |.|| :|...::|...:...|..|
  Fly  1827 ELGA-LNEALVDANEAMQQAAQSG 1849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10011NP_651624.2 ANKYR 1236..1489 CDD:440430 83/273 (30%)
ANK repeat 1270..1313 CDD:293786 14/42 (33%)
ANK repeat 1315..1347 CDD:293786 13/33 (39%)
ANK repeat 1349..1380 CDD:293786 12/38 (32%)
ANK repeat 1382..1413 CDD:293786 10/30 (33%)
ANK repeat 1415..1446 CDD:293786 12/38 (32%)
ANKYR 1469..1788 CDD:440430 67/287 (23%)
ANK repeat 1484..1515 CDD:293786 11/30 (37%)
ANK repeat 1517..1548 CDD:293786 9/30 (30%)
ANK repeat 1550..1581 CDD:293786 9/30 (30%)
ANK repeat 1617..1648 CDD:293786 5/36 (14%)
ANK repeat 1650..1682 CDD:293786 6/31 (19%)
ANK repeat 1684..1715 CDD:293786 7/30 (23%)
ANK repeat 1717..1742 CDD:293786 3/13 (23%)
ANK repeat 1750..1775 CDD:293786
rolsNP_729778.1 zf-RING_5 327..364 CDD:434085 7/36 (19%)
Ank_2 1382..1467 CDD:463710 35/99 (35%)
ANK repeat 1382..1408 CDD:293786 13/37 (35%)
ANK repeat 1410..1441 CDD:293786 12/30 (40%)
ANKYR 1481..1714 CDD:440430 76/240 (32%)
ANK repeat 1486..1518 CDD:293786 12/33 (36%)
ANK repeat 1521..1552 CDD:293786 12/33 (36%)
ANK repeat 1554..1586 CDD:293786 11/31 (35%)
ANK repeat 1591..1619 CDD:293786 11/27 (41%)
Spy 1608..>1847 CDD:443119 51/246 (21%)
ANK repeat 1621..1652 CDD:293786 9/30 (30%)
ANK repeat 1654..1685 CDD:293786 9/30 (30%)
ANK repeat 1687..1712 CDD:293786 6/24 (25%)
TPR repeat 1736..1768 CDD:276809 4/31 (13%)
TPR repeat 1773..1810 CDD:276809 8/43 (19%)
TPR repeat 1815..1843 CDD:276809 7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

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