Protein Alignment CG10011 and tanc2b

DIOPT Version :10

• Sequence 1: NP_651624.2
• Gene: CG10011 / 43387
• FlyBaseID: FBgn0039590
• Length: 2119
• Species: Drosophila melanogaster
• Sequence 2: XP_073774149.1
• Gene: tanc2b / 335127
• ZFINID: ZDB-GENE-030131-7067
• Length: 2164
• Species: Danio rerio
• Alignment Length: 2355
• Identity: 466/2355 - (19%)
• Similarity: 742/2355 - (31%)
• Gaps: 806/2355 - (34%)

  Fly   227 GETNGGSAPEED-GQEAAGGLK----------TQPTEDTDGNLEALMQRKVSPDKEVNGLVHSAG 280
            |:.|..|....| |.|..|.|:          |.|....|.:........|:|.....|..|...
Zfish    13 GKANRKSRISSDGGNEDGGDLQSAALDPFHSYTGPGGSVDSDCVFEGGYSVAPLSATEGFQHMRA 77

  Fly   281 VEPNNRIV--STVYIHREWVLKKIALCLEQRTAGKKSGPVALGGAASSSYVSARAKAAAISSSSY 343
            :|..:|.:  |.:..|:        :......:.:|....|.||..:..........||.:..:.
Zfish    78 MEGVSRSLPSSPLLTHQ--------ISSSHLPSARKIFSTATGGIGAELGPPPSVDEAANTLMTR 134

  Fly   344 NGCLVLGSNGSGKTSICQAIMKGNSGTKGI-LNRKLLACYLIESQN---PECHSLSLFMRKIVLQ 404
            .|.| ||...|..:...|..|:.....:|. .:.::..|..:.|..   |.|...|........|
Zfish   135 LGFL-LGDKVSEGSEEPQFSMEEPDDAQGFGASGRMSPCSTLTSSTASPPACSPCSTLPSAAPGQ 198

  Fly   405 LLSH--ASLISRDESQRIIDEGFSFLRDEAQQQEFKLDEAMNNISLSENAEELLIEELKRGASEC 467
            .::.  ::|.|||.........:|    |...:..|..:.....||.       :....|...:.
Zfish   199 AVTSPTSTLESRDSGIIATLTNYS----EPMDRSGKHGDGSRGSSLK-------LWHSHRSTLDS 252

  Fly   468 DTKELDNFQSQRTSTVNKAARTTLTRQQSEPAPLQAMDAVNSDEKTGSNYGTHPPKRASRERGDT 532
            ....:|...:..|.::||....:.....|.|.||..|...||...|.|.:
Zfish   253 SLYRVDENMTASTFSLNKIPEPSSVHYSSHPTPLYLMPRPNSVAATSSAH--------------- 302

  Fly   533 EQDKDMGSEKEQKQSQEPKETPKSSPAKSKSKIPVKRGRSGSGV---------------LSPSKL 582
              .:|:....||:.:  |..|....|.:|.:     .||||..:               |:|.:|
Zfish   303 --LEDLAYLDEQRHA--PLRTSLRMPRQSST-----AGRSGQDLRASANSHAWQSQSLRLAPYRL 358

  Fly   583 ATISNGGQSIQQGGGEDIADLNTDQEKHEIEAAIKDDKVEEPQANNEDKKEDKPEADKELNDQLK 647
                           :||              |:|....|.|....:.....:        |.|.
Zfish   359 ---------------QDI--------------ALKPLLFEVPSITMDSVFTGR--------DWLF 386

  Fly   648 EELDKSSQEPKEEETKEEATADSSAEPLIDFTESNVNGK---------------QEEPQLKPP-- 695
            :|:|...:     .|...::|.......|.|.::.:..:               .:.||..|.
Zfish   387 QEIDACLR-----STHSGSSAGVVLVGNIGFGKTAIISRLVALSCHGNRMRQIASDSPQASPKHG 446

  Fly   696 --VPGEKPRISTNTLP----PPLPKTKS------------------------------------- 717
              :|..:|:.|..||.    |..|:.:.
Zfish   447 DGIPLSQPQPSHGTLGGGSCPGTPEMRRRQEEAMRRLAAQVVAYHYCQSDNAYTCLVPEFVHNVA 511

  Fly   718 ---CRTIIADGYYELLLSNPEILECLSVDNIEKNPDECFKKAFLFPLLEL-----TPPKTALLLL 774
               ||:.....|.||||..|.|...||:.:..::|...|::..|.||..|     ..|:..|::|
Zfish   512 ALLCRSPQLTAYRELLLKEPHIQSMLSLRSCVQDPPTAFRRGVLEPLHALYKERKITPEEDLIIL 576

  Fly   775 IDSIDENYINEGNLISTLKGGRGTVTNHKSRNVAELLSNHIHLFPKWLFLVCTTKKQTKQITKMF 839
            ||.::|...::.:...|               :...|...|:.||.||.||.|.:...::|||..
Zfish   577 IDGLNEAEFHKPDYGDT---------------IVSFLCKTINKFPAWLKLVVTVRTTLQEITKPL 626

  Fly   840 TGFKKITLDDLRKSHVV-KDVQEYIINRLNS--DFKDSIMLTKEIIES-----LHQLYIKSNGCI 896
            . |.:|:||.|.::..: .|:|.||::|::|  :.:::|.|..::..|     ...|...|.|..
Zfish   627 P-FHQISLDALEENDAIDHDLQGYILHRIHSSAEIQNNISLNGKMDNSSFGKLSSHLKALSQGSF 690

  Fly   897 LYLEKVLHGIKDNFFSFR--EIKLIPCTLNGLYLYICQKSF-NKKQYMKIRPLLNVLLASSGYVD 958
            |||:.....|:..:...:  ..|::|.:|..:||..|...| .:..:.:..|||||.|||...:.
Zfish   691 LYLKLTFDLIERGYLVLKSSNYKVVPVSLAEVYLLQCNMRFPTQSSFERALPLLNVGLASLHPLT 755

  Fly   959 KLFLFNCLRTHNY--TIDCQEFEKRLQLMRNILAYDSNAQRLKIFHNSFADWLVDVKFATK-KFI 1020
            ...::..:...:.  |:|..:|::|::.:...|....:..|:.: |.||.:||:..:...| ||:
Zfish   756 DEQIYQAINGGSVKGTLDWDDFQQRMENLSVFLVKRRDGTRMFV-HPSFREWLIWREEGEKTKFL 819

  Fly  1021 CDVNEGHVMISMYYLLVADTLCANTVRRFAYHLIRSGEYLTSRHVDLDLILMLLESRLNLSDCFY 1085
            ||...||.:::.::....:.|.........:|::::
Zfish   820 CDPRNGHTLLAFWFSRQENKLNRQQTIELGHHILKA----------------------------- 855

  Fly  1086 TNQMNCCAQCEHDFKYDVNFLPKTRAMLERFLASELSEPFAQFLC---DFFKPSLPTDAKMLKLL 1147
                       |.||.....:..:.::|:....|..:|..:..|.   :.:.|::    |:.:||
Zfish   856 -----------HIFKGLSKKVGVSSSILQGLWVSYSTESLSTALSSLRNLYTPNI----KVSRLL 905

  Fly  1148 IETGINNAESQNSCESSLMSPELSEKSQNIDFELADLLLSSEKSCLMETQRAGSPSEHSEPPAES 1212
            |..|.|
Zfish   906 ILGGAN----------------------------------------------------------- 911

  Fly  1213 QDENASSTLHQLSDSHHIELHKGKALIHILANDGNHQLLERALNACKSPIDLEIEDYNGQTALNI 1277
                                                             ::...|..|....|.:
Zfish   912 -------------------------------------------------VNYRTEVLNNAPVLCV 927

  Fly  1278 AARNGHLEVVKLLLSFSQPCNDGTGRMKRVDVNHADRDGWTPLRSASWGGHSEVVRLLIAQPACK 1342
            .|..|:.::|.|||      .:|.|      |:.....|.|||..|:..||..:|..|..:.| |
Zfish   928 HAHLGYADMVNLLL------ENGAG------VDSPSESGLTPLGYAAAAGHLSIVTSLCKRKA-K 979

  Fly  1343 IDLADKEGRTALRAAAWSGHEDILKLLI------------------------------------- 1370
            :|..||.|:.||..||..||.|:||.||
Zfish   980 LDHLDKHGQCALVHAALRGHLDVLKFLIQNDWGQTHLQSPSPTQSQDTPSPVSQPQATPSPTPPD 1044

  Fly  1371 ---------------------ESGADVNSVDRQGR------------------------------ 1384
                                 |..|:....:.|.|
Zfish  1045 ATPSPTQATPTESPPSGPEQQEDPAETPQEEEQNREESPKEEVEKQTQEDTQAERSSSPSSVSFN 1109

  Fly  1385 ------TSLIAASYMGHYDIVEILLE---------NGANVNHLD-LDGRSALCVAALCGSSGYSK 1433
                  .:||||:.||:.:||..||:         ..|.:|..| |.|.:||..||   ..|..:
Zfish  1110 KSIAIQQALIAAASMGYTEIVSYLLDLPERDEEDIQRAQINSCDTLWGETALSAAA---GRGKLE 1171

  Fly  1434 VISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACTAGHA 1498
            |...||:.|:...|.:..|:.||..|..:|:.::.:||:.:.||.:|||..|||||..|.:.||.
Zfish  1172 VCRLLLEQGSAVAQPNRRGVLPLFSSVRQGHWQIVDLLVSHGADVNLADKQGRTPLMMAASEGHL 1236

  Fly  1499 TVVKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYAAFEGF 1563
            ..|:.|:..|..:|.||.||.|.||....:|::..||.|::||....|.|..|.|||..|||.|.
Zfish  1237 DTVEFLMAQGASMDLMDKEGLTALSWACLKGHLSVVRCLVERGAATDHADKNGRTPLDLAAFYGD 1301

  Fly  1564 HEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACL- 1627
            .:|...|::.||.::..|..|...|..|........|.|||              |...::.|.
Zfish  1302 SDVVQFLVDHGALVEHVDYSGMRPLDRAVGCRNTSVVVALL--------------KKGAKIGCQT 1352

  Fly  1628 -----EGHMDTVEFLLKFCCDVNSKDADSRTTLYILALENKLEIVKYLLDMTNVDVNIPDSEG-- 1685
                 :|...|...            |.|:..:.|:.|...||                :.:|
Zfish  1353 LPSPHKGGPATWAM------------ATSKPDIMIILLSKLLE----------------EGDGFY 1389

  Fly  1686 ------------RTALHVAAWQGHADMVKTLIEAGADVNSMDLEARTPLHSCAWQGNHDVMNILL 1738
                        :.||.....:|.::.:||..|....:.......|..::............:.|
Zfish  1390 KKGKVKEAAQRYQYALKKFPREGLSEDLKTFKELKVSLFLNLSRCRRKMNDFGMAEEFATKALEL 1454

  Fly  1739 --------YYGALADHACKQGATALGISAQEGHEKC-----VIALLQFGANPYK----------- 1779
                    |..|.|..:.:|.|.||. ..:|..:.|     :..|||.....|:
Zfish  1455 KPKSYEAFYARARAKRSSRQFAEALD-DLREAIKLCPNNREIQRLLQRVEEEYRQVTQSEELELE 1518

  Fly  1780 ---------------SDHCGRTP------------------------------IKLAAK-SSRTS 1798
                           .:....||                              |.||:. .|.||
Zfish  1519 PPPSPPPSPLPVEEDEEPPRHTPPPEPRLDDMEPVQDLFEDDDFLEQELEAVSIGLASDIRSNTS 1583

  Fly  1799 ILKIFESYTKNEA-------SNPNEPKFHAHASMLRSP-------DQPPALPLHQN-----LAPY 1844
            .|.|..|...:.|       |.....:||..:|.:.||       ..|...|.|||     ..|:
Zfish  1584 SLAIIRSPPLSPAHHDTGYLSGGQAFEFHPSSSSMSSPTHHSYQSTSPCISPTHQNSHYRQSPPH 1648

  Fly  1845 --PAHASA--------------------------------------SSVCSAATTATVHNGSHLH 1869
              |||.|:                                      .|||...:    .:||.:.
Zfish  1649 TSPAHQSSYRFSPPPMGGGGNQGMDYQSPPPSPLRRGVPFRASPPVESVCIYRS----QSGSPVR 1709

  Fly  1870 V------------LNASSSTHSSNNFYQNTMQSDTSSLHKRKSV--------------------- 1901
            .            |...||..|.....|.:..|.||..|:.:.:
Zfish  1710 YQQEPLPSRPKSPLLKMSSQRSFQLQSQPSQSSQTSQHHQVQGLRLQPSMAQIVRTNQPSNSVYS 1774

  Fly  1902 -----ISSQSTGSS------NDQAP-LTFTQQLQRQSKLSSRNNLMVNS--KHASSSGAAG---- 1948
                 :||:..|||      .|:.| |.:...|..:|....:::|.|.:  :|....|.:|
Zfish  1775 QLAHPLSSRYQGSSMDVDRDRDREPRLVYQPSLDGRSMSQVQSSLSVGALCQHGGRGGPSGVLES 1839

  Fly  1949 --------------HKSSGGGGGAQRHSQVLPDLSEHQLASNMTNEADMYDMECMSPLYATPPHS 1999
                          ::|:.||.|..|.||. |.:|..|.|:..  ....:::|......|.||
Zfish  1840 NLGKDELPQRPASAYRSATGGPGGMRFSQT-PQISRSQSAAYY--PVSKHELERAVAASALPP-- 1899

  Fly  2000 PSSELSSPGQLPGL----------------------------NAFVDDERAGTSSGGGAKL---- 2032
              .:|.|| ::|.|                            |.......:..|||....|
Zfish  1900 --CQLGSP-EIPHLVRRPISANTSDLKQHVPTPRPLIHSQSVNLRFSPSSSNISSGSSCNLASGF 1961

  Fly  2033 -PDNHFARDTHMRIILGNLKE---NQPSSSGKSKRSGVSSNPAMRLIRSRFDAASQLIRRTNNIL 2093
             |.:..|:   |.|.|....|   ::||:...|:....|..|.    |||......:|.:|....
Zfish  1962 RPSSSMAQ---MEIPLQVAYERSFDEPSALSPSQSGHYSGEPT----RSRTTPFMGVIDKTARTT 2019

  Fly  2094 SSSSNQGSSSIGVKS 2108
            ....:|.|.:..|.|
Zfish  2020 QQYLHQPSRAWPVSS 2034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	ANKYR	1236..1489	CDD:440430	82/356 (23%)
		ANK repeat	1270..1313	CDD:293786	11/42 (26%)
		ANK repeat	1315..1347	CDD:293786	12/31 (39%)
		ANK repeat	1349..1380	CDD:293786	14/88 (16%)
		ANK repeat	1382..1413	CDD:293786	14/75 (19%)
		ANK repeat	1415..1446	CDD:293786	10/30 (33%)
		ANKYR	1469..1788	CDD:440430	88/407 (22%)
		ANK repeat	1484..1515	CDD:293786	12/30 (40%)
		ANK repeat	1517..1548	CDD:293786	12/30 (40%)
		ANK repeat	1550..1581	CDD:293786	12/30 (40%)
		ANK repeat	1617..1648	CDD:293786	4/36 (11%)
		ANK repeat	1650..1682	CDD:293786	5/31 (16%)
		ANK repeat	1684..1715	CDD:293786	7/44 (16%)
		ANK repeat	1717..1742	CDD:293786	3/32 (9%)
		ANK repeat	1750..1775	CDD:293786	9/29 (31%)
tanc2b	XP_073774149.1	None