Protein Alignment CG10011 and Tanc1

DIOPT Version :10

• Sequence 1: NP_651624.2
• Gene: CG10011 / 43387
• FlyBaseID: FBgn0039590
• Length: 2119
• Species: Drosophila melanogaster
• Sequence 2: XP_006234266.1
• Gene: Tanc1 / 311055
• RGDID: 1302949
• Length: 1856
• Species: Rattus norvegicus
• Alignment Length: 1906
• Identity: 399/1906 - (20%)
• Similarity: 660/1906 - (34%)
• Gaps: 543/1906 - (28%)

  Fly   431 EAQQQEFKLDEAMNNISLSENAEELL------------------IEE--------LKRGASECDT 469
            |..:.|.|:|   |..|.|..|:|||                  ||:        |.:|.|.|.|
  Rat   114 EPIETEAKVD---NEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNEAMCTALSQGISPCST 175

  Fly   470 -------KELDNFQSQRTSTVNKAA--RTTLTRQQSEPAPLQAMD---------AVNSDEKTGSN 516
                   ...|:..|...|.|:|.|  ::......|..:.|::.|         :..:|:::||:
  Rat   176 LTSSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRSGSS 240

  Fly   517 --YGTHPPKRASRERG---DTEQDKDMGSEKEQKQSQEPKETPKSSPAKSKSKIPVKRGRSGSGV 576
              :......|...::|   |...|......:|:.........||:..:.....:|..:. ||| :
  Rat   241 LEWNRDGSLRLGVQKGVLHDRRADNCSPVAEEETTGSAESVLPKAESSAGDGPVPYSQS-SGS-L 303

  Fly   577 LSP---SKLATISNGGQSIQQGGGEDIADLNTD----------QEKHEIEAAIKDDKVEE----- 623
            :.|   |..||.|...:.:....|:..|.|.|.          ....|::|.....|.:|
  Rat   304 IMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHSTAGGRAQEVKARFAPYKPQEILLKP 368

  Fly   624 -----PQANNEDKKEDKPEADKELNDQLKE-ELDK------------------------------ 652
                 |....:.....:....:::.:.|:. ||.:
  Rat   369 LLFEVPSITTDSVFVGRDWLFQQIEENLRNTELAENRGAVVVGNVGFGKTAIISKLVALSCHGSR 433

  Fly   653 ----SSQEPKEEETKEEATADSSAEPLIDFTES-NVNGKQEEPQLKPPVPGEKPR---------- 702
                :|..|.......:.|.|....||:..:.| :..|....|.....|..::||
  Rat   434 MRQIASSSPSSSLKTSDPTHDLPGTPLLSPSSSTSALGAARTPPGPGTVDSQRPREDAVKYLASK 498

  Fly   703 -------ISTNTLPPPLPK------TKSCRTIIADGYYELLLSNPEILECLSVDNIEKNPDECFK 754
                   .:.||....:|:      ...||:.....|.:||:..|::...|::.:..::|...||
  Rat   499 VVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIREPQLQSMLNLRSCVQDPVAAFK 563

  Fly   755 KAFLFPLLELTP----PKTALLLLIDSIDENYINEGNLISTLKGGRGTVTNHKSRNVAELLSNHI 815
            :..|.||..|..    |:...::|||.::|...::.:...||               :..::..|
  Rat   564 RGILEPLTNLRNEQKIPEEEYIILIDGLNEAEFHKPDYGDTL---------------SSFITKII 613

  Fly   816 HLFPKWLFLVCTTKKQTKQITKMFTGFKKITLDDL-RKSHVVKDVQEYIINRLNS--DFKDSIML 877
            ..||.||.|:.|.:...::|..... |.|::|||. ....:..|:..|:.:|::|  |...:|.|
  Rat   614 PKFPPWLKLIVTVRADFQEIISTLP-FVKLSLDDFPGNQDIHSDLHAYVQHRVHSSQDILSNISL 677

  Fly   878 TKEIIESL-----HQLYIKSNGCILYLEKVLHGIKDNFFSFR--EIKLIPCTLNGLYLYICQKSF 935
            ..:...:|     ..|.::|.|..|||:..|...:......:  ..|::|.:|:.|||..|...|
  Rat   678 NGKADAALIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYKVVPVSLSELYLLQCNMKF 742

  Fly   936 -NKKQYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNYTID--CQEFEKRLQLMRNILAYDSNAQR 997
             .:..:.:..|:|||.|||...:....:|..:...:...:  .::|::|::.:...|....:..|
  Rat   743 MTQSAFDRALPILNVALASLHPMTDEQIFQAINAGHIQGEQGWEDFQQRMEALSCFLIKRRDKTR 807

  Fly   998 LKIFHNSFADWLV-DVKFATKKFICDVNEGHVMISMYYLLVADTLCANTVRRFAYHLIRSGEYLT 1061
            : ..|.||.:||| .....:..|:|:...||.:::..:......|.........:|::::
  Rat   808 M-FCHPSFREWLVWRADGESTAFLCEPRNGHALLAFMFSRQESKLNRQQTVELGHHILKA----- 866

  Fly  1062 SRHVDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFLPKT-------RAMLERFLAS 1119
                                               |.||   ....||       :|:...:...
  Rat   867 -----------------------------------HIFK---GLSKKTGVSSSHLQALWIGYSTE 893

  Fly  1120 ELSEPFAQFLCDFFKPSLPTDAKMLKLLIETGINNAESQNSCESSLMSPELSEKSQNIDFELADL 1184
            .||...|. |.:.:.|::    |:.:|||..|.|
  Rat   894 GLSAALAS-LRNLYTPNV----KVSRLLILGGAN------------------------------- 922

  Fly  1185 LLSSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHIELHKGKALIHILANDGNHQ 1249
                                                                             
  Rat   923 ----------------------------------------------------------------- 922

  Fly  1250 LLERALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPCNDGTGRMKRVDVNHADR 1314
                        ::...|..|....|.:.:..||.|||.|||.|. .|.||           ...
  Rat   923 ------------VNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFG-ACLDG-----------MSE 963

  Fly  1315 DGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLI----ESGAD 1375
            :|...|..|:..||.::|.||..:.| ::|..||:|:.||..:|..||.|||:.|:    .:|..
  Rat   964 NGMNALCYAAAAGHMKLVCLLTKKGA-RVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPP 1027

  Fly  1376 VNSVDRQGRT---SLIAASYMGHYDIVEILL----ENGANVNHLD-LDGRSALCVAALCGSSGYS 1432
            .....|:.:.   :|.||:.|||..:|:.||    |:...||..| |.|.:||..||   ..|..
  Rat  1028 QPGTLRKSQALQQALTAAASMGHSAVVQSLLGMAEEHEIEVNGTDTLWGETALTAAA---GRGKL 1089

  Fly  1433 KVISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACTAGH 1497
            ::...||:.||...:.:..|:.||..::.:|:.:|.:|||:...|.:|.|..|||||..|...||
  Rat  1090 EICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVQLLLDRGCDVNLNDKQGRTPLMVAACEGH 1154

  Fly  1498 ATVVKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYAAFEG 1562
            .:.|:.||..|..:..:|.||.:.||....:|:...|:.|::.|.:....|..|.|||..|||.|
  Rat  1155 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYG 1219

  Fly  1563 FHEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACL 1627
            ..|..|.|:|.||.|:..|:.|...|..|     :.|....:.:  :.:.:.|..|..|:.:|
  Rat  1220 DAETVLYLVEKGAVIEHVDHSGMRPLDRA-----IGCRNTAVVV--TLLRKGAKLGNAAWAMA-- 1275

  Fly  1628 EGHMDTVEFLLKFCCDVNS--------KDADSRTTLYILALE--------------NKLEIVKYL 1670
            ....|.:..||:...:..:        |:|..|   |..||.              |:|.:..||
  Rat  1276 TSKPDILIILLQKLMEEGNVMYKKGKMKEAAQR---YQYALRKFPREGLGEDMRPFNELRVSLYL 1337

  Fly  1671 -----LDMTNVDVNIPDSEGRTALHVAAWQGHADMVKTLIEAGADVNS-------MDLEARTPLH 1723
                 ...|| |..:.:.....||.:......|...:    |.|..||       .||:....|
  Rat  1338 NLSRCRRKTN-DFGLAEEFASKALELKPKSYEAFYAR----ARAKRNSRQFLAALADLQEAVKL- 1396

  Fly  1724 SCAWQGNHDVMNILLYYGALADHACKQGATALGISAQEGHEKCVIALLQFGANPYKSDHCGRTPI 1788
             |  ..|.::..:|    |..:..|||        .|...::...|.|.  |.|..||:....|
  Rat  1397 -C--PTNQEIKRLL----ARVEEECKQ--------LQRNQQQKQQAPLP--APPNDSDNDEEAP- 1443

  Fly  1789 KLAAKSSRTSILKIFESYTKNEASNPNEPKFHAHASMLRSPDQPPALPLHQNLAPY--------- 1844
                    .|.||  :.:...||...:........|.......||::|     :||
  Rat  1444 --------ASSLK--DHFPIEEAEEEDTSSQEESISPTPRSQPPPSVP-----SPYIRNLQEGLQ 1493

  Fly  1845 ----PAHASASSVCSAATTATVHN--------------GSHLHVLNASSSTHSSNNFYQNTMQSD 1891
                ||...:.:..|.:...||..              .::.|:.:..||..:||...|.:.|:.
  Rat  1494 SKGRPASPQSRAGISKSLRETVAQPGLVMQPTKQAQIVKTNQHLGSGQSSMRNSNTKVQVSSQNP 1558

  Fly  1892 TSS-----LHKRKSVISSQ--------STGSS----NDQAPLTFTQQLQR---------QSKLSS 1930
            ..|     :....:|..:|        |||:.    .|:...:.:.||||         .||:.:
  Rat  1559 PPSPMPGRVSAAPAVSRNQHLEGTGPFSTGTGCGHFGDRLGPSQSLQLQRGESGTAYPLPSKVKA 1623

  Fly  1931 RNNLMVNSKHASSSGAAGHKSSGGGGGAQ--RHSQVLPDLSEHQLASNMTNEADMYDMECMSPLY 1993
            ...|:.   |||.:......|.||.....  ||..        .|:|:.::
  Rat  1624 AERLLA---HASVAVDMAPPSQGGPVSCSDVRHPA--------SLSSSGSS-------------- 1663

  Fly  1994 ATPPHSPSSELSSPGQLPGLNAFVDDERAGTSSGGGAKLPDNHFARDTHMRIILGNLKENQPSSS 2058
                .||||.:........|.:     .:..|.|..|:.||:.. ||.....:.|...|::|.::
  Rat  1664 ----GSPSSSVKMSSSTSSLTS-----SSSVSDGFKAQGPDSRI-RDRGTTQVQGGTAEHRPRNT 1718

  Fly  2059 ------GKSKRSGVSSNPAMR 2073
                  .|:.|.....||..|
  Rat  1719 PFMGIMDKTARFQQQVNPPSR 1739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	ANKYR	1236..1489	CDD:440430	77/264 (29%)
		ANK repeat	1270..1313	CDD:293786	14/42 (33%)
		ANK repeat	1315..1347	CDD:293786	10/31 (32%)
		ANK repeat	1349..1380	CDD:293786	11/34 (32%)
		ANK repeat	1382..1413	CDD:293786	12/37 (32%)
		ANK repeat	1415..1446	CDD:293786	10/30 (33%)
		ANKYR	1469..1788	CDD:440430	92/352 (26%)
		ANK repeat	1484..1515	CDD:293786	12/30 (40%)
		ANK repeat	1517..1548	CDD:293786	8/30 (27%)
		ANK repeat	1550..1581	CDD:293786	15/30 (50%)
		ANK repeat	1617..1648	CDD:293786	6/38 (16%)
		ANK repeat	1650..1682	CDD:293786	11/50 (22%)
		ANK repeat	1684..1715	CDD:293786	7/37 (19%)
		ANK repeat	1717..1742	CDD:293786	4/24 (17%)
		ANK repeat	1750..1775	CDD:293786	4/24 (17%)
Tanc1	XP_006234266.1	NACHT	<518..1262	CDD:444362	214/939 (23%)
		PHA03095	903..>1215	CDD:222980	107/439 (24%)
		ANK repeat	936..962	CDD:293786	13/37 (35%)
		ANK repeat	964..995	CDD:293786	10/31 (32%)
		ANKYR	1076..1282	CDD:440430	68/217 (31%)
		ANK repeat	1076..1106	CDD:293786	10/32 (31%)
		ANK repeat	1112..1139	CDD:293786	9/26 (35%)
		ANK repeat	1142..1172	CDD:293786	12/29 (41%)
		ANK repeat	1174..1205	CDD:293786	8/30 (27%)
		ANK repeat	1207..1238	CDD:293786	15/30 (50%)
		ANK repeat	1240..1265	CDD:293786	4/31 (13%)
		TPR repeat	1289..1314	CDD:276809	5/27 (19%)
		TPR	1293..>1410	CDD:440225	27/132 (20%)
		TPR repeat	1332..1362	CDD:276809	7/30 (23%)
		TPR repeat	1367..1395	CDD:276809	7/31 (23%)