DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10011 and Ankrd28

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	XP_038950906.1	Gene:	Ankrd28 / 306264	RGDID:	1559931	Length:	1053	Species:	Rattus norvegicus

Alignment Length:	1035	Identity:	266/1035 - (25%)
Similarity:	417/1035 - (40%)	Gaps:	250/1035 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1181 LADLLLSSEKSCLMETQRAGSPSE-----HSEPPAESQDENASSTLH---QLSDSHHIELHKGKA 1237
            :|.|.|..:.| |::....|.|.|     ..:.....||....:.||   .|.|:..|||
  Rat     1 MAFLKLRDQPS-LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIEL----- 59

  Fly  1238 LI----HILANDGNHQL-LERALNAC---------KSPIDLEIEDYNGQTALNIAARNGHLEVVK 1288
            ||    .:.|.|..... |.||:.:|         |...|:...|.|.||.|:|||.|..::..:
  Rat    60 LILSGARVNAKDSKWLTPLHRAVASCSEEAVQILLKHSADVNARDKNWQTPLHIAAANKAVKCAE 124

  Fly  1289 LLLSFSQPCNDGTGRMKRVDVNHADRDGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTA 1353
            .|:....            :||.:||.|.|.|..|::.||.|:|:||:::.| .|:..||:.|.|
  Rat   125 SLVPLLS------------NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGA-NINAFDKKDRRA 176

  Fly  1354 LRAAAWSGHEDILKLLIESGADVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLDGRS 1418
            :..||:.||.:::|||:..||:|...|::..|.|.||:..|...:|:.||:.|.::|..:..|.:
  Rat   177 IHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNT 241

  Fly  1419 ALCVAALCGSSGYSKVISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVC-ELLLENAADPDLAD 1482
            .|.||..   :|...|::.|:|.|||.:|.:..|.:||..::...:..:| |||:.|.||.::..
  Rat   242 PLHVACY---NGQDVVVNELIDCGANVNQKNERGFTPLHFAAASTHGALCLELLVGNGADVNMKS 303

  Fly  1483 FMGRTPLWAACTAGHATVVKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHR 1547
            ..|:|||......|..:..:.::..|..|||.|..|.|.|.|.|..|:...:..|:..|.|...|
  Rat   304 KDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKR 368

  Fly  1548 DNAGWTPLHYAAFEGFHEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVD 1612
            ...|..|||.||..||.:.|.:||.||..||..|:.|:|.||.||..|.|.|:..||:..:.| :
  Rat   369 GIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADF-N 432

  Fly  1613 QKAHDGKTAFRLA--------------------------CLEGH----MDT----VEFLLKFCCD 1643
            :|...|::....|                          |...|    .||    :|:||:...:
  Rat   433 KKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDAN 497

  Fly  1644 VNSKDADS------------RTTLYILALENKLEIV------KYLLDMTN--------------- 1675
            ...:|...            |..|.::|.|..|:::      ..|.|..|
  Rat   498 PGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGH 562

  Fly  1676 -----------VDVNIPDSEGRTALHVAAWQGHADMVKTLIEAGADVNSMD-LEARTPLHSCAWQ 1728
                       :|:::.:|.|||.|.:||::||.:.|..||..||.:...| :..|||:|:.|..
  Rat   563 HQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYVLKRTPIHAAATN 627

  Fly  1729 GNHDVMNI------------------------------------LLYYGALADHACKQGATALGI 1757
            |:.:.:.:                                    ||..||..|...|.|.|||..
  Rat   628 GHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHR 692

  Fly  1758 SAQEGHEKCVIALLQFGANPYKSDHCGRTPIKLAAKSSRTSIL-KIFESYTKNEASNPNEPKFHA 1821
            .|..|||:||.||||.||.....|..|||||.|:|......:| .:.:|.|..:| ||.....|.
  Rat   693 GAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSATSVDA-NPAIVDNHG 756

  Fly  1822 H-------------------------------------------------------ASMLRSPDQ 1831
            :                                                       ||::.:||.
  Rat   757 YTALHWACYNGHETCVELLLEQDVFQKIDGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNAPDS 821

  Fly  1832 PPALPLHQNLAPYPAHASASSVCSAATTATVHNGSHLHVLNASSST------HSSNNFYQNTMQ- 1889
            ....|||  .|.:..|.....:..:....          :|::.||      .::.|...||::
  Rat   822 KGRTPLH--AAAFTDHVECLQLLLSQNAQ----------VNSADSTGKTPLMMAAENGQTNTVEM 874

  Fly  1890 ------SDTSSLHKRKSVISSQSTGSSNDQAPLTFTQQLQRQSKLSSRNNLMVNSKH-ASSSGAA 1947
                  :|.:...|.|:.....:.|..::.:.|...:::..::.:::.|..:....| |:.:|..
  Rat   875 LVSSASADLTLQDKSKNTALHLACGKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLT 939

  Fly  1948 GHKSSGGGGGAQRHSQVLPDLSEHQLASNMTNEADMYDMECMSPLYAT-PPHSPSSELSS 2006
            .......|.||   |.:..|.:.:..|.......|:.|  |::.:.|| .|.|.:|.|:|
  Rat   940 MVVQELLGKGA---SVLAVDENGYTPALACAPNKDVAD--CLALILATMMPVSSNSPLTS 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728
		Ank_4	1237..1291	CDD:290365	19/67 (28%)
		ANK	1266..1403	CDD:238125	47/136 (35%)
		ANK repeat	1270..1313	CDD:293786	11/42 (26%)
		Ank_2	1275..1380	CDD:289560	36/104 (35%)
		ANK repeat	1315..1347	CDD:293786	12/31 (39%)
		ANK repeat	1349..1380	CDD:293786	12/30 (40%)
		Ank_2	1354..1449	CDD:289560	33/94 (35%)
		ANK repeat	1382..1413	CDD:293786	10/30 (33%)
		ANK	1410..1538	CDD:238125	39/128 (30%)
		ANK repeat	1415..1446	CDD:293786	11/30 (37%)
		Ank_5	1438..1489	CDD:290568	18/51 (35%)
		ANK	1479..1604	CDD:238125	45/124 (36%)
		ANK repeat	1484..1515	CDD:293786	9/30 (30%)
		Ank_2	1489..1581	CDD:289560	32/91 (35%)
		ANK repeat	1517..1548	CDD:293786	9/30 (30%)
		ANK repeat	1550..1581	CDD:293786	15/30 (50%)
		Ank_2	1555..1648	CDD:289560	36/126 (29%)
		ANK	1578..1705	CDD:238125	44/204 (22%)
		ANK repeat	1617..1648	CDD:293786	9/64 (14%)
		Ank_2	1624..1715	CDD:289560	32/168 (19%)
		ANK	1645..1771	CDD:238125	48/206 (23%)
		ANK repeat	1650..1682	CDD:293786	9/75 (12%)
		ANK repeat	1684..1715	CDD:293786	13/30 (43%)
		Ank_2	1689..1781	CDD:289560	39/128 (30%)
		ANK repeat	1717..1742	CDD:293786	8/60 (13%)
		ANK repeat	1750..1775	CDD:293786	14/24 (58%)
Ankrd28	XP_038950906.1	ANK repeat	12..38	CDD:293786	4/25 (16%)
		PHA03095	22..>310	CDD:222980	95/308 (31%)
		ANK repeat	40..71	CDD:293786	10/35 (29%)
		ANK repeat	76..104	CDD:293786	6/27 (22%)
		ANK repeat	106..137	CDD:293786	11/42 (26%)
		ANK repeat	140..170	CDD:293786	12/30 (40%)
		ANK repeat	172..203	CDD:293786	12/30 (40%)
		PHA03095	186..>454	CDD:222980	90/271 (33%)
		ANK repeat	205..236	CDD:293786	10/30 (33%)
		ANK repeat	238..269	CDD:293786	12/33 (36%)
		ANK repeat	271..302	CDD:293786	10/30 (33%)
		ANK repeat	305..336	CDD:293786	9/30 (30%)
		ANK repeat	338..363	CDD:293786	7/24 (29%)
		ANK repeat	371..402	CDD:293786	15/30 (50%)
		ANK repeat	404..435	CDD:293786	12/31 (39%)
		ANK repeat	437..468	CDD:293786	2/30 (7%)
		ANK repeat	470..502	CDD:293786	7/31 (23%)
		Ank_2	475..580	CDD:403870	16/104 (15%)
		ANK repeat	552..580	CDD:293786	1/27 (4%)
		PHA02874	554..>863	CDD:165205	71/321 (22%)
		ANK repeat	582..613	CDD:293786	13/30 (43%)
		ANK repeat	618..650	CDD:293786	6/31 (19%)
		ANK repeat	652..683	CDD:293786	5/30 (17%)
		ANK repeat	685..716	CDD:293786	16/30 (53%)
		ANK repeat	718..747	CDD:293786	10/28 (36%)
		ANK repeat	755..820	CDD:293786	3/64 (5%)
		ANK repeat	823..853	CDD:293786	6/41 (15%)
		Ank_2	827..920	CDD:403870	15/104 (14%)
		ANK repeat	855..887	CDD:293786	5/31 (16%)
		ANK repeat	889..920	CDD:293786	3/30 (10%)
		ANK repeat	925..956	CDD:293786	7/33 (21%)
		Ank	927..957	CDD:394980	7/32 (22%)
		Ank_2	930..1006	CDD:423045	19/70 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910