DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10011 and Ankrd44

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	XP_017451840.1	Gene:	Ankrd44 / 301415	RGDID:	1561893	Length:	1074	Species:	Rattus norvegicus

Alignment Length:	1131	Identity:	287/1131 - (25%)
Similarity:	441/1131 - (38%)	Gaps:	317/1131 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1190 KSC----LMETQRAGSPSE-----HSEPPAESQDENASSTLHQ---LSDSHHIELHKGKALI--- 1239
            |.|    |::...:|.|.|     |......:.|....:.||.   |.|:..|||     ||
  Rat     5 KLCDQPPLVQAIFSGDPEEIRLLIHKTEDVNALDSEKRTPLHVAAFLGDAEIIEL-----LILSG 64

  Fly  1240 -HILANDGNHQL--LERALNA---------CKSPIDLEIEDYNGQTALNIAARNGHL---EVVKL 1289
             .:.|.| |..|  |.||:.:         .|...|:...|.|.|:.:::||.|..:   ||:..
  Rat    65 ARVNAKD-NMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQSPVHVAAANKAVKCAEVIIP 128

  Fly  1290 LLSFSQPCNDGTGRMKRVDVNHADRDGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTAL 1354
            |||               .||.:||.|.|.|..|:..||.|:|.||:|:.| .|:..||:.|.||
  Rat   129 LLS---------------SVNVSDRGGRTALHHAALNGHMEMVNLLLAKGA-NINAFDKKDRRAL 177

  Fly  1355 RAAAWSGHEDILKLLIESGADVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLDGRSA 1419
            ..||:.||.|::.|||..||:|...|::|.|.|.||:..|..::|:.||..|..::.:::.|.:|
  Rat   178 HWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTA 242

  Fly  1420 LCVAALCGSSGYSKVISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVC-ELLLENAADP----- 1478
            |.:|..   :|...|::.|:|:|||.:|.:|.|.:||..::...:..:| |||:.|.||.
  Rat   243 LHIACY---NGQDAVVNELIDYGANVNQPNNSGFTPLHFAAASTHGALCLELLVNNGADVNIQSK 304

  Fly  1479 ----------------------------DLADFMGRTPLWAACTAGHATVVKLLLFWG-----CG 1510
                                        |..|..|.|||..|...||..::..|:..|     ||
  Rat   305 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCG 369

  Fly  1511 I---------------DCM-------------------------------DSEGRTVLSIGAAQG 1529
            |               ||.                               |:.|||.|...||.|
  Rat   370 IHSMFPLHLAALNAHSDCCRKLLSSGQKYSIVSLFSNEHVLSAGFEIDTPDTFGRTCLHAAAAGG 434

  Fly  1530 NVETVRQLLDRGLDETHRDNAGWTPLHYAAFE-GFHEVCLQ-LLESGAKIDECDNEGKTALHLAA 1592
            |||.::.|...|.|...:|..|.|||||||.. .||  |:: |:.:||.|:|.||.|:||||.||
  Rat   435 NVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFH--CIKALVTTGANINETDNWGRTALHYAA 497

  Fly  1593 QE---------GRLH-------------------CVQALL--DIHSSFVDQKAHDGKTAFRLACL 1627
            ..         |..|                   |::.||  |.:.|..|:   :|..:...|..
  Rat   498 ASDMDRNKMILGNAHDNSEELERAREVKGKDAALCLEFLLQNDANPSIRDK---EGYNSIHYAAA 559

  Fly  1628 EGHMDTVEFLLKFCCDVNSKDADS---RTTLYILALENKLEIVKYLLDMTNVDVNIPDSEGRTAL 1689
            .||...:|.||: ..:...:::|.   ::.|::.|.....:.::.|| .:.||::|.|.:|||||
  Rat   560 YGHRQCLELLLE-RTNTGFEESDGGALKSPLHLAAYNGHHQALEVLL-QSLVDLDIRDEKGRTAL 622

  Fly  1690 HVAAWQGHADMVKTLIEAGADVNSMD-LEARTPLHSCAWQGN----------------------- 1730
            ::||::||.:.|:.|:..||.:...| :..|||||:....|:
  Rat   623 YLAAFKGHTECVEALVNQGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEVVDVKDAK 687

  Fly  1731 ------------H-DVMNILLYYGALADHACKQGATALGISAQEGHEKCVIALLQFGANPYKSDH 1782
                        | |.:::||...|..|.....|.|||......|||:||..||:..|:....|.
  Rat   688 GQTPLMLAVAYGHIDAVSLLLEKEANVDAVDTVGCTALHRGIMTGHEECVQMLLEQEASILCKDS 752

  Fly  1783 CGRTPIKLAAK---------------SSRTSILKIFESYTK--------NE-------------- 1810
            .||||:..||.               |.....||..:.||.        ||
  Rat   753 RGRTPLHYAAARGHATWLNELVQIALSEEDCCLKDNQGYTPLHWACYNGNENCIEVLLEQKCFRK 817

  Fly  1811 -ASNPNEPK----FHAH------------ASMLRSPDQPPALPLHQNLAPYPAHASASSVC---S 1855
             ..||..|.    .:.|            :|::...|......||  .|.:..||....:.   .
  Rat   818 FIGNPFTPLHCAIINGHESCASLLLGAIDSSIVSCRDDKGRTTLH--AAAFGDHAECLQLLLRHD 880

  Fly  1856 AATTATVHNGSHLHVLNASSSTHSSNNFYQNTMQSDTSSLHKRKSVISSQSTGSSNDQAPLTFTQ 1920
            |...|..::|....::.|.:....:.:...|:.|:|.:...|..:.....:....:::..|....
  Rat   881 AQVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLAISKGHEKCALLILD 945

  Fly  1921 QLQRQSKLSSRNNLMVNSKH-ASSSGAAGHKSSGGGGGAQRHSQVLPDLSEHQLASNMTNEADMY 1984
            ::|.:|.::::|:.:....| |:.:|...........||   ..:..|.:.|..|.......|:.
  Rat   946 KIQDESLINAKNSALQTPLHIAARNGLKVVVEELLAKGA---CVLAVDENGHTPALACAPNKDVA 1007

  Fly  1985 DMECMSPLYAT-PPHSPSSELSSPGQLPGLNAFVDDERAGTSSGGGAKLPDNHFARDTHMRIILG 2048
            |  |::.:.|| ...||||.:::..       ||                  :|.:|...|..|.
  Rat  1008 D--CLALILATMMTFSPSSTMTAVN-------FV------------------YFRKDNLSRRTLS 1045

  Fly  2049 NL-------KENQPSSSGKSKRSGVS 2067
            |:       ..|..|..|.::....|
  Rat  1046 NMGSRVSLCSNNLDSEGGYNENDSDS 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728
		Ank_4	1237..1291	CDD:290365	19/71 (27%)
		ANK	1266..1403	CDD:238125	52/139 (37%)
		ANK repeat	1270..1313	CDD:293786	12/45 (27%)
		Ank_2	1275..1380	CDD:289560	41/107 (38%)
		ANK repeat	1315..1347	CDD:293786	13/31 (42%)
		ANK repeat	1349..1380	CDD:293786	14/30 (47%)
		Ank_2	1354..1449	CDD:289560	35/94 (37%)
		ANK repeat	1382..1413	CDD:293786	10/30 (33%)
		ANK	1410..1538	CDD:238125	50/212 (24%)
		ANK repeat	1415..1446	CDD:293786	11/30 (37%)
		Ank_5	1438..1489	CDD:290568	21/84 (25%)
		ANK	1479..1604	CDD:238125	59/205 (29%)
		ANK repeat	1484..1515	CDD:293786	14/81 (17%)
		Ank_2	1489..1581	CDD:289560	42/144 (29%)
		ANK repeat	1517..1548	CDD:293786	13/30 (43%)
		ANK repeat	1550..1581	CDD:293786	16/32 (50%)
		Ank_2	1555..1648	CDD:289560	37/124 (30%)
		ANK	1578..1705	CDD:238125	44/159 (28%)
		ANK repeat	1617..1648	CDD:293786	7/30 (23%)
		Ank_2	1624..1715	CDD:289560	28/93 (30%)
		ANK	1645..1771	CDD:238125	44/165 (27%)
		ANK repeat	1650..1682	CDD:293786	8/34 (24%)
		ANK repeat	1684..1715	CDD:293786	13/30 (43%)
		Ank_2	1689..1781	CDD:289560	34/128 (27%)
		ANK repeat	1717..1742	CDD:293786	10/60 (17%)
		ANK repeat	1750..1775	CDD:293786	11/24 (46%)
Ankrd44	XP_017451840.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820