DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10011 and Ankrd50

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	NP_001178535.1	Gene:	Ankrd50 / 294988	RGDID:	1311665	Length:	1427	Species:	Rattus norvegicus

Alignment Length:	1477	Identity:	545/1477 - (36%)
Similarity:	796/1477 - (53%)	Gaps:	259/1477 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   718 CRTIIADGYYELLLSNPEILECLSVDNIEKNPDECFKKAFLFPLLELTPPKTALLLLIDSIDENY 782
            |::.:..| ||..|.:|.:...|.....|:||.|.||:..|.|||.:.||..:|.||:||:||..
  Rat   135 CQSGLLQG-YEDKLRDPAVQSLLEPGECERNPAEAFKRCVLLPLLGMKPPPQSLYLLVDSVDEGC 198

  Fly   783 INEGNLISTLKGGRGTVTNHKSRNVAELLSNHIHLFPKWLFLVCTTKKQTKQITKMFTGFKKITL 847
                |::.    |..|..| .|..|||||:.|...||.||.|:|:.:||::.:|||||||:||:|
  Rat   199 ----NVVE----GEQTSPN-LSGTVAELLAGHHEFFPPWLLLLCSARKQSRAVTKMFTGFRKISL 254

  Fly   848 DDLRKSHVVKDVQEYIINRLNSDFKDSIMLTKEIIESLHQLYIKSNGCILYLEKVLHGIKDNFFS 912
            |||||:::|||||:||::||:.:......||||..|:|:||:|||:||.||||:||.|:.:||..
  Rat   255 DDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAETLNQLHIKSSGCFLYLERVLDGVVENFIM 319

  Fly   913 FREIKLIPCTLNGLYLYICQKSFNKKQYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNYTIDCQE 977
            .|||:.||.|||||||::||:.|.:||:.|::|:|||:||:...:....|::.:.|.|.::..::
  Rat   320 LREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAACRPLTMTELYHAVWTKNMSLTLED 384

  Fly   978 FEKRLQLMRNILAYDSNAQRLKIFHNSFADWLVDVKFATKKFICDVNEGHVMISMYYLLVADTLC 1042
            |:::|.::..:|.....:.:: :||:|||:||:|||..|:|::|:..|||.|::|.|...|..|.
  Rat   385 FQRKLDVLSKLLVDGLGSTKI-LFHHSFAEWLLDVKHCTQKYLCNAAEGHRMLAMSYTCQARNLT 448

  Fly  1043 ANTVRRFAYHLIRSGEYLTSRHVDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFLP 1107
            ....:.||.|||.|...|.    ..:|.|.::.:...:.|...|
  Rat   449 PLEAQEFALHLINSNLQLE----PAELALWMIWNGTPVKDSLST--------------------- 488

  Fly  1108 KTRAMLERFLASELSEPFAQFLCDFFKPSLPTDAKMLKLLIETG--INNAESQNSCESSLMSPEL 1170
                                        .:|.:.::|:|||..|  :|:.:.:.||    :..:.
  Rat   489 ----------------------------LIPKEQEVLQLLIRAGAHVNSEDDRTSC----IVRQA 521

  Fly  1171 SEKSQNIDFELADLLLSSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHIELHKG 1235
            .|:..:|     ..||.|..|                  ....|.|..:.|...:.|..::
  Rat   522 LEREDSI-----RTLLDSGAS------------------VNQCDSNGRTLLANAAYSGSLD---- 559

  Fly  1236 KALIHILANDGNHQLLERALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPCNDG 1300
              ::::|.:.|               .||||||.:|.|.|.:|||.||.:||..|:        |
  Rat   560 --VVNLLVSRG---------------ADLEIEDTHGHTPLTLAARQGHTKVVNCLI--------G 599

  Fly  1301 TGRMKRVDVNHADRDGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDI 1365
            .|    .::||.|:||||.||||:||||:|||..|: ....|:|.||.:.|||||||||.|||||
  Rat   600 CG----ANINHTDQDGWTALRSAAWGGHTEVVSALL-YAGVKVDCADADSRTALRAAAWGGHEDI 659

  Fly  1366 LKLLIESGADVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLDGRSALCVAALC--GS 1428
            :..|::.||:||..|.:|||:||||:||||.:|||.||::||.|||.|:|||:||.|||||  .|
  Rat   660 VLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPAS 724

  Fly  1429 SGYSKVISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAAC 1493
            .|::.|:|.|:|.||..|..|.|||:||||:::||:.:|.:||||..||.|..|..|||||.||.
  Rat   725 KGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA 789

  Fly  1494 TAGHATVVKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYA 1558
            :.|||:||..|||||..:|.:||||||||||.:||||||.||.||||||||:|||:|||||||.|
  Rat   790 SMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDESHRDDAGWTPLHMA 854

  Fly  1559 AFEGFHEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFR 1623
            ||||...:|..|:|.||:.:|.||:|:....||:|||...|||.||: :.|.:||:.:||:.|.|
  Rat   855 AFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE-NKSNIDQRGYDGRNALR 918

  Fly  1624 LACLEGHMDTVEFLLKFCCDVNSKDADSRTTLYILALENKLEIVKYLLDMTNVDVNIPDSEGRTA 1688
            :|.||||.|.||.|.....|||.||||.|.|||||||||:|.:.:|.|: ...:|...|:|||||
  Rat   919 VAALEGHRDIVELLFSHGADVNYKDADGRPTLYILALENQLTMAEYFLE-NGANVEASDAEGRTA 982

  Fly  1689 LHVAAWQGHADMVKTLIEAGADVNSMDLEARTPLHSCAWQGNHDVMNILLYYGALADHACKQGAT 1753
            |||:.||||.:||:.||...||||:.|.|.|:.|.|.||||:..|:.:|:.:||:.||.|.||||
  Rat   983 LHVSCWQGHVEMVRVLIACHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGAT 1047

  Fly  1754 ALGISAQEGHEKCVIALLQFGANPYKSDHCGRTPIKLAAKSSRTSILKIFESYTKNEASNPNEPK 1818
            ||.|:|||||...|..||:.||:|..:|..|||.:::|||:..:.|:|:.|.|..:..:..:...
  Rat  1048 ALCIAAQEGHVDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSP 1112

  Fly  1819 FHAHASMLRSPDQP-----PALPLHQN---------LAPY-------PAHASASSVCSAATT--- 1859
            .|   :|.:.|.|.     .:|.:..|         |.|.       ||||.:|...|..:|
  Rat  1113 VH---TMEQKPPQSTPSKMQSLTIRSNSSGGTGGGDLQPSLRGLPNGPAHAFSSPSESPDSTVDR 1174

  Fly  1860 --ATVHNGSHLHVLNASSSTHSSN--------------NFYQNTMQSDTSSLHKRKSVIS----S 1904
              :::.|.|.....|:|..|.||.              :|.:...|........|:||:|    :
  Rat  1175 QKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHSLSFTEQIQQHSLPRSRSRQSVVSPSSTT 1239

  Fly  1905 QSTGSSNDQAPLTFTQQLQRQSKLSSRNNLMVNSKHASSSGAAGHKSSGGGGGAQRHSQVLPDLS 1969
            ||.|.|::.....|.....:.|..|:::|....|:::|.||:||.|       |::::...|.:.
  Rat  1240 QSLGHSHNSPSSEFEWSQVKPSLKSTKSNKGGKSENSSKSGSAGKK-------AKQNNSSQPKVL 1297

  Fly  1970 EHQLASNMTNEADMYDMECMSPLYATPPHSPSSELSSPGQLPGLNAFVDDERAGTSSGGGAKLPD 2034
            |:::..                                          .|:|...:..|.:  |.
  Rat  1298 EYEMTQ------------------------------------------FDKRGPVAKSGSS--PP 1318

  Fly  2035 NHFARDTHMRIILGNLKEN---QP-----SSSGKSK-RSGVSSNPAMRLIRSRFDAASQLIRRTN 2090
            .....::..:|::.:.:::   ||     ...|:.| |:|:.:||...|..::.......:.||
  Rat  1319 KQMPAESQCKIMVPSSQDSNRAQPQFLIHQQGGEQKRRNGIMTNPNYHLQSNQVFLGRVSVPRT- 1382

  Fly  2091 NILSSSSNQ--------GSSSIGVKSG----------TFQWRKESQM 2119
              |....:|        ..:.:.:|..          :|.::||:.:
  Rat  1383 --LQERGHQEVLEGFPPSETELNLKQALKLQIEGSDPSFNYKKETPL 1427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728	54/112 (48%)
		Ank_4	1237..1291	CDD:290365	18/53 (34%)
		ANK	1266..1403	CDD:238125	73/136 (54%)
		ANK repeat	1270..1313	CDD:293786	15/42 (36%)
		Ank_2	1275..1380	CDD:289560	53/104 (51%)
		ANK repeat	1315..1347	CDD:293786	18/31 (58%)
		ANK repeat	1349..1380	CDD:293786	19/30 (63%)
		Ank_2	1354..1449	CDD:289560	58/96 (60%)
		ANK repeat	1382..1413	CDD:293786	21/30 (70%)
		ANK	1410..1538	CDD:238125	77/129 (60%)
		ANK repeat	1415..1446	CDD:293786	18/32 (56%)
		Ank_5	1438..1489	CDD:290568	27/50 (54%)
		ANK	1479..1604	CDD:238125	78/124 (63%)
		ANK repeat	1484..1515	CDD:293786	18/30 (60%)
		Ank_2	1489..1581	CDD:289560	61/91 (67%)
		ANK repeat	1517..1548	CDD:293786	25/30 (83%)
		ANK repeat	1550..1581	CDD:293786	18/30 (60%)
		Ank_2	1555..1648	CDD:289560	45/92 (49%)
		ANK	1578..1705	CDD:238125	66/126 (52%)
		ANK repeat	1617..1648	CDD:293786	16/30 (53%)
		Ank_2	1624..1715	CDD:289560	51/90 (57%)
		ANK	1645..1771	CDD:238125	69/125 (55%)
		ANK repeat	1650..1682	CDD:293786	15/31 (48%)
		ANK repeat	1684..1715	CDD:293786	20/30 (67%)
		Ank_2	1689..1781	CDD:289560	49/91 (54%)
		ANK repeat	1717..1742	CDD:293786	10/24 (42%)
		ANK repeat	1750..1775	CDD:293786	15/24 (63%)
Ankrd50	NP_001178535.1	AAA_16	23..195	CDD:404141	24/60 (40%)
		PHA03095	480..>717	CDD:222980	112/346 (32%)
		ANK repeat	544..575	CDD:293786	9/51 (18%)
		ANK repeat	577..608	CDD:293786	15/42 (36%)
		ANK repeat	610..641	CDD:293786	18/31 (58%)
		PHA03095	625..>907	CDD:222980	167/283 (59%)
		ANK repeat	643..674	CDD:293786	19/30 (63%)
		ANK repeat	676..707	CDD:293786	21/30 (70%)
		ANK repeat	709..745	CDD:293786	19/35 (54%)
		ANK repeat	747..778	CDD:293786	17/30 (57%)
		PHA02876	<763..>1102	CDD:165207	190/340 (56%)
		ANK repeat	780..811	CDD:293786	18/30 (60%)
		ANK repeat	813..844	CDD:293786	25/30 (83%)
		ANK repeat	847..877	CDD:293786	17/29 (59%)
		ANK repeat	879..910	CDD:293786	14/31 (45%)
		ANK repeat	912..943	CDD:293786	16/30 (53%)
		ANK repeat	945..976	CDD:293786	15/31 (48%)
		ANK repeat	978..1009	CDD:293786	20/30 (67%)
		ANK repeat	1011..1042	CDD:293786	14/30 (47%)
		ANK repeat	1044..1075	CDD:293786	18/30 (60%)
		ANK repeat	1077..1102	CDD:293786	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BFJC
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	725	1.000	Inparanoid score	I591
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004643
OrthoInspector	1	1.000	-	-		oto96483
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	1	1.100	-	-	LDO	PTHR24123
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4356
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.790