Protein Alignment CG10011 and TANC2

DIOPT Version :10

• Sequence 1: NP_651624.2
• Gene: CG10011 / 43387
• FlyBaseID: FBgn0039590
• Length: 2119
• Species: Drosophila melanogaster
• Sequence 2: XP_011522899.1
• Gene: TANC2 / 26115
• HGNCID: 30212
• Length: 2075
• Species: Homo sapiens
• Alignment Length: 2021
• Identity: 412/2021 - (20%)
• Similarity: 660/2021 - (32%)
• Gaps: 638/2021 - (31%)

  Fly   220 DVAHHANGETNGGSAPEEDGQEAAGGLKTQPTEDTDGNLEALMQRKVSPDKEVN-GLVHSAGVEP 283
            ||..:..|:......|.....|||..|.|:        |..|:..||:   ||. |..:|..|:.
Human   138 DVDAYCPGDAEQELGPPPSVDEAANTLMTR--------LGFLLGEKVT---EVQPGDQYSMEVQD 191

  Fly   284 NNRIVSTVYIHREWVLKKIALC--LEQRTAGKKSGPVALGGAASSSYVSARAKAAAISSSSYNGC 346
            .|:..:        :.::|:.|  |...||    .|.|....::...:|..|.|   ...||...
Human   192 ENQTSA--------ITQRISPCSTLTSSTA----SPPASSPCSTLPPISTNATA---KDCSYGAV 241

  Fly   347 LVLGSNGSGKTSICQAIMKGNSGTKGILNRKLLACYLIESQNPECHSLSLFMRKIVLQLLSHASL 411
                      ||....:...:||                               |:..|.|::..
Human   242 ----------TSPTSTLESRDSG-------------------------------IIATLTSYSEN 265

  Fly   412 ISR----DESQRIIDEGFSFLRDEAQQQEFKLDEAMNNISLSENAEELLIEELKRGASECDTKEL 472
            :.|    .||.:.:..|.:.  ...|.|:..:|..:..:
Human   266 VERTKYAGESSKELGSGGNI--KPWQSQKSSMDSCLYRV-------------------------- 302

  Fly   473 DNFQSQRTSTVNKAAR---TTLTRQQSEPAPLQAMDAVNSDEKTGSNY---------GTHPPKRA 525
            |...:..|.::||...   .|:..|..:..||..|...||...|.|.:         ..|.|.|.
Human   303 DENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRT 367

  Fly   526 SRERGDTEQDKDMGSEKEQKQSQEPKETPKSSPAKSKSKIPVKRGRSGSGVLSPSKLATISNGGQ 590
            |...    ..:.||..:.| |....:..|...|..|               |.|......|...:
Human   368 SLRM----PRQSMGGARTQ-QDLRVRFAPYRPPDIS---------------LKPLLFEVPSITTE 412

  Fly   591 SIQQGGGEDIADLNTDQEKHEIEAAIKDDKVEEPQ--------------------------ANNE 629
            |:..|         .|...|||:|.::.......|                          ....
Human   413 SVFVG---------RDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMR 468

  Fly   630 DKKEDKPEADKELNDQLKEELDKSSQEPKEEETKEEATADSSAEPLIDFTESNVNGKQEEP--QL 692
            ....|.|.|.       .:.:|.:.:.|..:.....::..|.:.|    ....:..:|||.  :|
Human   469 QIASDSPHAS-------PKHVDANRELPLTQPPSAHSSITSGSCP----GTPEMRRRQEEAMRRL 522

  Fly   693 KPPVPGEKPRISTNTLPPPLPK------TKSCRTIIADGYYELLLSNPEILECLSVDNIEKNPDE 751
            ...|.......:.|.....:|:      ...||:.....|.|.||..|.:...||:.:..::|..
Human   523 ASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPHLQSMLSLRSCVQDPMA 587

  Fly   752 CFKKAFLFPLLELTP----PKTALLLLIDSIDENYINEGNLISTLKGGRGTVTNHKSRNVAELLS 812
            .|::..|.||..|..    |....::|||.::|...::.:...|               :...||
Human   588 SFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDT---------------IVSFLS 637

  Fly   813 NHIHLFPKWLFLVCTTKKQTKQITKMFTGFKKITLDDLRKSHVV-KDVQEYIINRL--NSDFKDS 874
            ..|..||.||.|:.|.:...::|||:.. |.:|.||.|.::..: :|:|.||::|:  :|:.:::
Human   638 KMIGKFPSWLKLIVTVRTSLQEITKLLP-FHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNN 701

  Fly   875 IMLTKEIIE------SLHQLYIKSNGCILYLEKVLHGIKDNFFSFR--EIKLIPCTLNGLYLYIC 931
            |.|..::..      |.| |...|.|..|||:.....|:..:...:  ..|::|.:|:.:||..|
Human   702 ISLNGKMDNTTFGKLSSH-LKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQC 765

  Fly   932 QKSF-NKKQYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNY--TIDCQEFEKRLQLMRNILAYDS 993
            ...| .:..:.::.|||||.:||...:....:|..:...:.  |::.::|::|::.:...|....
Human   766 NMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRR 830

  Fly   994 NAQRLKIFHNSFADWLVDVKFATK-KFICDVNEGHVMISMYYLLVADTLCANTVRRFAYHLIRSG 1057
            :..|:.: |.||.:||:..:...| ||:||...||.:::.::......|.........:|::::
Human   831 DMTRMFV-HPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKA- 893

  Fly  1058 EYLTSRHVDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFLPKTRAMLERFLASELS 1122
                                                   |.||.....:..:.::|:....|..:
Human   894 ---------------------------------------HIFKGLSKKVGVSSSILQGLWISYST 919

  Fly  1123 EPFAQFLC---DFFKPSLPTDAKMLKLLIETGINNAESQNSCESSLMSPELSEKSQNIDFELADL 1184
            |..:..|.   :.:.|::    |:.:|||..|.|
Human   920 EGLSMALASLRNLYTPNI----KVSRLLILGGAN------------------------------- 949

  Fly  1185 LLSSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHIELHKGKALIHILANDGNHQ 1249
                                                                             
Human   950 ----------------------------------------------------------------- 949

  Fly  1250 LLERALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPCNDGTGRMKRVDVNHADR 1314
                        |:...|..|....|.:.:..|:.|:|.|||.|.            .:|:.:..
Human   950 ------------INYRTEVLNNAPILCVQSHLGYTEMVALLLEFG------------ANVDASSE 990

  Fly  1315 DGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLIESGADVNSV 1379
            .|.|||..|:..|:..:| :|:.:...|:|..||.|:.||..||..||.:::|.||:....: :.
Human   991 SGLTPLGYAAAAGYLSIV-VLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTM-AG 1053

  Fly  1380 DRQG--------RTSLIAASYMGHYDIVEILLE---------NGANVNHLD-LDGRSALCVAALC 1426
            .:||        :.:||||:.||:.:||..||:         ..|.:|..| |.|.:||..||
Human  1054 QQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAA-- 1116

  Fly  1427 GSSGYSKVISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWA 1491
             ..|..:|...||:.||...|.:..|..||..:..:|:.::.:|||.:.||.::||..|||||..
Human  1117 -GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMM 1180

  Fly  1492 ACTAGHATVVKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLH 1556
            |.:.||...|..||..|..|..||.||.|.||....:|::..||.|:|.|....|.|..|.|||.
Human  1181 AASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLD 1245

  Fly  1557 YAAFEGFHEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTA 1621
            .|||.|..||...|::.||.|:..|..|...|..|
Human  1246 LAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRA------------------------------ 1280

  Fly  1622 FRLACLEGHMDTVEFLLKFCCDVNSKDADSRTTLYILALENKLEIVKYLLDMTNVDVNIPDSEGR 1686
              :.|                         |.|
Human  1281 --VGC-------------------------RNT-------------------------------- 1286

  Fly  1687 TALHVAAWQGHADMVKTLIEAGADVNSMDLEARTPLHSCAW---QGNHDVMNILL---------- 1738
                        .:|.||::.||.:....|.:| |.....|   ....|:|.|||
Human  1287 ------------SVVVTLLKKGAKIGCQTLPSR-PRGPATWAMATSKPDIMIILLSKLMEEGDMF 1338

  Fly  1739 YYGALADHACKQGATALGISAQEG--------HEKCVIALLQFGANPYKSDHCGRTPIKLAAKSS 1795
            |.......|.::...||....:||        .|..|..||.......|.:..|      .|:..
Human  1339 YKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFG------MAEEF 1397

  Fly  1796 RTSIL----KIFESY-------------------TKNEASN--PNEP-------KFHAHASMLRS 1828
            .|..|    |.:|:|                   ..|||..  ||..       :.......::.
Human  1398 ATKALELKPKSYEAYYARARAKRSSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQ 1462

  Fly  1829 PDQPPALP-----LHQNLAPYPAHASASSVCSAATTATVHNGSHLH--VLNASSSTHSSNNFYQN 1886
            |.|||..|     |.:...|.|.|....||      ..:....:|.  |.|.|....:.....|.
Human  1463 PQQPPPPPQPQQQLPEEAEPEPQHEDIYSV------QDIFEEEYLEQDVENVSIGLQTEARPSQG 1521

  Fly  1887 --TMQSDTSS-LHKRKSVISSQSTGSSN--DQAPLTFTQQLQRQSKLSSRNNLMVNSKHASSSGA 1946
              .:||..|| .|:..:.|||...||..  |....:......||:..|:...|....:::....:
Human  1522 LPVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQNSHYRPS 1586

  Fly  1947 AGHKSSGGGGGAQRHS-------------------------QVLPDLSEHQLASNMTNEADMYDM 1986
            ..|.|....||:.|.|                         :..|......:..:.:.....|..
Human  1587 PPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQ 1651

  Fly  1987 ECMSPLYATPPHSPSSELSS-PGQLPGLNAFVDDERAGTSSGGGAKLPDNHFARDTHMRIILGNL 2050
            |.........|.||.|:::. |.|:|.|...|..:        |.:|      :....:|:
Human  1652 ETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQ--------GLRL------QPAKAQIV---- 1698

  Fly  2051 KENQPS 2056
            :.||||
Human  1699 RSNQPS 1704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	ANKYR	1236..1489	CDD:440430	76/270 (28%)
		ANK repeat	1270..1313	CDD:293786	10/42 (24%)
		ANK repeat	1315..1347	CDD:293786	10/31 (32%)
		ANK repeat	1349..1380	CDD:293786	10/30 (33%)
		ANK repeat	1382..1413	CDD:293786	14/47 (30%)
		ANK repeat	1415..1446	CDD:293786	11/30 (37%)
		ANKYR	1469..1788	CDD:440430	82/339 (24%)
		ANK repeat	1484..1515	CDD:293786	13/30 (43%)
		ANK repeat	1517..1548	CDD:293786	12/30 (40%)
		ANK repeat	1550..1581	CDD:293786	14/30 (47%)
		ANK repeat	1617..1648	CDD:293786	1/30 (3%)
		ANK repeat	1650..1682	CDD:293786	2/31 (6%)
		ANK repeat	1684..1715	CDD:293786	5/30 (17%)
		ANK repeat	1717..1742	CDD:293786	9/37 (24%)
		ANK repeat	1750..1775	CDD:293786	8/32 (25%)
TANC2	XP_011522899.1	PHA03095	930..>1224	CDD:222980	101/422 (24%)
		ANK repeat	963..989	CDD:293786	9/37 (24%)
		ANK repeat	991..1022	CDD:293786	10/31 (32%)
		ANKYR	1100..1299	CDD:440430	80/302 (26%)
		ANK repeat	1108..1138	CDD:293786	12/32 (38%)
		ANK repeat	1140..1171	CDD:293786	9/30 (30%)
		ANK repeat	1174..1204	CDD:293786	13/29 (45%)
		ANK repeat	1206..1237	CDD:293786	12/30 (40%)
		ANK repeat	1239..1270	CDD:293786	14/30 (47%)
		ANK repeat	1272..1302	CDD:293786	11/130 (8%)
		TPR repeat	1331..1356	CDD:276809	3/24 (13%)
		TPR	1335..>1450	CDD:440225	23/120 (19%)
		TPR repeat	1361..1404	CDD:276809	11/48 (23%)
		TPR repeat	1409..1438	CDD:276809	5/28 (18%)
		PHA03247	<1512..1741	CDD:223021	41/211 (19%)