DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10011 and ANKRD28

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	NP_001336206.1	Gene:	ANKRD28 / 23243	HGNCID:	29024	Length:	1086	Species:	Homo sapiens

Alignment Length:	1021	Identity:	265/1021 - (25%)
Similarity:	404/1021 - (39%)	Gaps:	259/1021 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1200 GSPSE-----HSEPPAESQDENASSTLH---QLSDSHHIELHKGKALI----HILANDGNHQL-L 1251
            |.|.|     ..:.....||....:.||   .|.|:..|||     ||    .:.|.|..... |
Human    52 GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIEL-----LILSGARVNAKDSKWLTPL 111

  Fly  1252 ERALNAC---------KSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPCNDGTGRMKRV 1307
            .||:.:|         |...|:...|.|.||.|:|||.|..::..:.|:....
Human   112 HRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLS------------ 164

  Fly  1308 DVNHADRDGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLIES 1372
            :||.:||.|.|.|..|::.||.|:|:||:::.| .|:..||:.|.|:..||:.||.:::|||:..
Human   165 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGA-NINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 228

  Fly  1373 GADVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLDGRSALCVAALCGSSGYSKVIST 1437
            ||:|...|::..|.|.||:..|...:|:.||:.|.::|..:..|.:.|.||..   :|...|::.
Human   229 GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACY---NGQDVVVNE 290

  Fly  1438 LLDHGANTDQLDNDGMSPLLVSSFEGNAEVC-ELLLENAADPDLADFMGRTPLWAACTAGHATVV 1501
            |:|.||..:|.:..|.:||..::...:..:| |||:.|.||.::....|:|||......|..:..
Human   291 LIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRS 355

  Fly  1502 KLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYAAFEGFHEV 1566
            :.::..|..|||.|..|.|.|.|.|..|:...:..|:..|.|...|...|..|||.||..||.:.
Human   356 QTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDC 420

  Fly  1567 CLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLA------ 1625
            |.:||.||..||..|:.|:|.||.||..|.|.|:..||:..:.| ::|...|::....|
Human   421 CRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADF-NKKDKFGRSPLHYAAANCNY 484

  Fly  1626 --------------------CLEGH----MDT----VEFLLKFCCDVNSKDADS----------- 1651
                                |...|    .||    :|:||:...:...:|...
Human   485 QCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYG 549

  Fly  1652 -RTTLYILALENKLEIV------KYLLDMTN--------------------------VDVNIPDS 1683
             |..|.::|.|..|:::      ..|.|..|                          :|:::.:|
Human   550 HRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNS 614

  Fly  1684 EGRTALHVAAWQGHADMVKTLIEAGADVNSMD-LEARTPLHSCAWQGNHDVMNI----------- 1736
            .|||.|.:||::||.:.|..||..||.:...| :..|||:|:.|..|:.:.:.:
Human   615 SGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAV 679

  Fly  1737 -------------------------LLYYGALADHACKQGATALGISAQEGHEKCVIALLQFGAN 1776
                                     ||..||..|...|.|.|||...|..|||:||.||||.||.
Human   680 DIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 744

  Fly  1777 PYKSDHCGRTPIKLAAKSSRTSIL----------------------------------------- 1800
            ....|..|||||.|:|......:|
Human   745 CLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL 809

  Fly  1801 --KIFESYTKNEASNP------NEPKFHAH-------ASMLRSPDQPPALPLHQNLAPYPAH--- 1847
              ::|:. |:..|.:|      |:.:..|.       ||::.:.|.....|||  .|.:..|
Human   810 EQEVFQK-TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLH--AAAFTDHVEC 871

  Fly  1848 --------ASASSVCSAATT---ATVHNGS----HLHVLNASSSTHSSNNFYQNTMQSDTSSLHK 1897
                    |..:||.|...|   ....||.    .:.|.:||:.....:|.....:....|..|:
Human   872 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHE 936

  Fly  1898 RKSVISSQSTGSSNDQAPLTFTQ-QLQRQSKLSSRNNLMVNSKHASSSGAAGHKSSGGGGGAQRH 1961
            ..:::..:..   .|:..:..|. .||....:::||.|.:..:.....||
Human   937 TSALLILEKI---TDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGA--------------- 983

  Fly  1962 SQVLPDLSEHQLASNMTNEADMYDMECMSPLYAT-PPHSPSSELSS 2006
            |.:..|.:.:..|.......|:.|  |::.:.|| .|.|.||.|||
Human   984 SVLAVDENGYTPALACAPNKDVAD--CLALILATMMPVSSSSPLSS 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728
		Ank_4	1237..1291	CDD:290365	19/67 (28%)
		ANK	1266..1403	CDD:238125	47/136 (35%)
		ANK repeat	1270..1313	CDD:293786	11/42 (26%)
		Ank_2	1275..1380	CDD:289560	36/104 (35%)
		ANK repeat	1315..1347	CDD:293786	12/31 (39%)
		ANK repeat	1349..1380	CDD:293786	12/30 (40%)
		Ank_2	1354..1449	CDD:289560	32/94 (34%)
		ANK repeat	1382..1413	CDD:293786	10/30 (33%)
		ANK	1410..1538	CDD:238125	38/128 (30%)
		ANK repeat	1415..1446	CDD:293786	10/30 (33%)
		Ank_5	1438..1489	CDD:290568	17/51 (33%)
		ANK	1479..1604	CDD:238125	45/124 (36%)
		ANK repeat	1484..1515	CDD:293786	9/30 (30%)
		Ank_2	1489..1581	CDD:289560	32/91 (35%)
		ANK repeat	1517..1548	CDD:293786	9/30 (30%)
		ANK repeat	1550..1581	CDD:293786	15/30 (50%)
		Ank_2	1555..1648	CDD:289560	36/126 (29%)
		ANK	1578..1705	CDD:238125	44/204 (22%)
		ANK repeat	1617..1648	CDD:293786	9/64 (14%)
		Ank_2	1624..1715	CDD:289560	32/168 (19%)
		ANK	1645..1771	CDD:238125	48/206 (23%)
		ANK repeat	1650..1682	CDD:293786	9/75 (12%)
		ANK repeat	1684..1715	CDD:293786	13/30 (43%)
		Ank_2	1689..1781	CDD:289560	39/128 (30%)
		ANK repeat	1717..1742	CDD:293786	8/60 (13%)
		ANK repeat	1750..1775	CDD:293786	14/24 (58%)
ANKRD28	NP_001336206.1	ANK repeat	45..71	CDD:293786	3/18 (17%)
		PHA03095	55..>343	CDD:222980	94/308 (31%)
		ANK repeat	73..104	CDD:293786	10/35 (29%)
		ANK repeat	109..137	CDD:293786	6/27 (22%)
		ANK repeat	139..170	CDD:293786	11/42 (26%)
		ANK repeat	173..203	CDD:293786	12/30 (40%)
		ANK repeat	205..236	CDD:293786	12/30 (40%)
		ANK repeat	238..269	CDD:293786	10/30 (33%)
		PHA03095	252..>508	CDD:222980	78/259 (30%)
		ANK repeat	271..302	CDD:293786	11/33 (33%)
		ANK repeat	304..335	CDD:293786	10/30 (33%)
		ANK repeat	338..369	CDD:293786	9/30 (30%)
		ANK repeat	371..396	CDD:293786	7/24 (29%)
		ANK repeat	404..435	CDD:293786	15/30 (50%)
		ANK repeat	437..468	CDD:293786	12/31 (39%)
		ANK repeat	470..501	CDD:293786	2/30 (7%)
		ANK repeat	503..535	CDD:293786	7/31 (23%)
		Ank_2	508..613	CDD:403870	16/104 (15%)
		ANK repeat	585..613	CDD:293786	1/27 (4%)
		PHA02874	587..>896	CDD:165205	72/311 (23%)
		ANK repeat	615..646	CDD:293786	13/30 (43%)
		ANK repeat	651..683	CDD:293786	6/31 (19%)
		ANK repeat	685..716	CDD:293786	5/30 (17%)
		ANK repeat	718..749	CDD:293786	16/30 (53%)
		ANK repeat	751..780	CDD:293786	8/28 (29%)
		ANK repeat	855..886	CDD:293786	7/32 (22%)
		Ank_2	860..953	CDD:403870	18/97 (19%)
		ANK repeat	888..920	CDD:293786	6/31 (19%)
		ANK repeat	922..953	CDD:293786	3/33 (9%)
		ANK repeat	958..989	CDD:293786	8/45 (18%)
		Ank	960..990	CDD:394980	7/44 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910