DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10011 and T28D6.4

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	NP_499461.1	Gene:	T28D6.4 / 176566	WormBaseID:	WBGene00012124	Length:	991	Species:	Caenorhabditis elegans

Alignment Length:	1212	Identity:	280/1212 - (23%)
Similarity:	461/1212 - (38%)	Gaps:	368/1212 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   688 EEPQ-LKPPVP----GEK----------PRISTNTLPPPLPKTKSCRTIIADGYYELLLSNPEIL 737
            :||| .:||..    ||:          ||::|.||   |..|.|
Worm    70 DEPQSSEPPTVIRSLGEQLMRRFPNLVLPRLTTVTL---LEDTVS-------------------- 111

  Fly   738 ECLSVDNIEKNPDECFKKAFLFPLLELTPPKTA--LLLLIDSIDENYINEGNLISTLKGGRGTVT 800
               ::|:..:.|.|             |.|.|:  :.|:|||:::
Worm   112 ---ALDHFLRLPLE-------------TMPSTSKPVFLVIDSVED-------------------- 140

  Fly   801 NHKSRNVAELLSNHIHLFPKWLFLVCTTKKQTKQITKMFTGFKKITLDDLRKSHVVKDVQEYIIN 865
             .:::.:.|:|   :.:.|.|:.:|.|::.:|...|            :|.:.|:
Worm   141 -EETQVLVEML---VEILPPWIQIVTTSRDRTNSET------------ELLELHI---------- 179

  Fly   866 RLNSDFKDSIML------TKEIIESLHQLYIKSNGCILYLEKVLHGIKDNFFSFREIKLIPCTL- 923
              :|||...|.|      .:|:.|:       |:|...|:|::...:        |:.::|..:
Worm   180 --DSDFDKFIRLKLPHCHVEEVREA-------SDGSWFYVEQLARAV--------ELGMVPSDMV 227

  Fly   924 --NGL--YLYICQKSFNKK--------QYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNYTIDCQ 976
              .|:  .:::..:|..:.        :..:.||....|||.|..:             .:.|..
Worm   228 PPIGVEKMMHLVARSLPRSFADIVRLAKTSRNRPTRQQLLAVSQML-------------VSRDIS 279

  Fly   977 EFEKRLQLMRNILAYDSNAQRLKIFHNSFADWLVDVKF---ATKKFICDVNEGHVMISMYYLL-- 1036
            ..||.::::.:::...|:....:|||      :.|:.|   ..:.|.|     |...:.:|..
Worm   280 VLEKDIRIITSLIGTASSENPSEIFH------VPDIWFQLIGEENFRC-----HTAWAEHYKTKR 333

  Fly  1037 --VADTLCANTVRRFAYHLIRSGEYLTSRHVDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDF 1099
              .|..:|     ..||||..|                            .||.:|.
Worm   334 RKSAQDIC-----ELAYHLSHS----------------------------TTNPLNA-------- 357

  Fly  1100 KYDVNFLPKTRAMLERFLASELSEPFAQFLCDFFKPSLPTDAKMLKLLIETGINNAESQNSCESS 1164
                                                        :|.|...|..|
Worm   358 --------------------------------------------VKTLQSVGAGN---------- 368

  Fly  1165 LMSPELSEKSQNIDFELADLLLSSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHH 1229
                 |..:...||.....||.|           ||:..|          ||....::..|
Worm   369 -----LVLRCHVIDLPTTALLKS-----------AGARME----------ENNYDVVYACS---- 403

  Fly  1230 IELHKGKALIHILANDGNHQLLERALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLL---- 1290
                           .|:...|:..|...| |:.::|     ...|..||..|::|:.:.|
Worm   404 ---------------VGDVSYLDAILREMK-PVPMDI-----CFGLLTAAARGNIEMCRFLADHF 447

  Fly  1291 --LSFSQPCNDGTGRMKRVDVNHADRDGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTA 1353
              |..|..|.:                 |..||||:..|..|::.||: :....:|......|||
Worm   448 PHLVASSCCGE-----------------WNALRSAACYGQLEILHLLL-EKGVDVDECGHSDRTA 494

  Fly  1354 LRAAAWSGHEDILKLLIESGADVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLDGRS 1418
            ||||||||....::||:::||:|:..|.:.||:|:||::|.|.|:|.::::.||:||.:|..|.:
Worm   495 LRAAAWSGQLAAVQLLLQTGAEVDRRDSEQRTALMAAAFMCHKDVVSVIIQYGADVNAIDKSGAT 559

  Fly  1419 ALCVAALCGS--SGYSKVISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVC-ELLLENAADPDL 1480
            ||.:....||  ...|:....||:|.|:....|.:|...|.::::.|  :.| :|:||.....|:
Worm   560 ALHLNLSNGSKQEENSETTKLLLEHNADCKIEDANGRVALHLAAYHG--DPCLQLILEKHPIVDV 622

  Fly  1481 ADFMGRTPLWAACTAGHATVVKLLLFWG-CGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDE 1544
            .|.||:|||..|.:.|....|:.|.... ..:|.:|:.|||.|...|..|:.|.|..|...|.||
Worm   623 MDNMGQTPLMLAASQGQLEAVQFLTKTAKADVDAIDNNGRTALQWAAINGHPEVVEFLCSVGSDE 687

  Fly  1545 THRDNAGWTPLHYAAFEGFHEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSS 1609
            .|:||.|...||||.... |...::.|.:...::..|..|:..:.:||..|.|..::.|:.| |.
Worm   688 GHKDNDGAVALHYAVTHD-HVELVKHLTNQHTVEAKDRYGQHPMMIAAANGNLKVLEYLMGI-SD 750

  Fly  1610 FVDQKAHDGKTAFRLACLEGHMDTVEFLLKFCCDVNSKDADSRTTLYILALENKLEIVKYLLDMT 1674
            .::|..|:|:||..||.:..|...::.:.....|.:.:|.|.....:.|.|.|.:.:.:..|. .
Worm   751 IINQPDHEGRTALSLASMAAHTSIIDLISPRITDWSQRDHDGTPLAHTLILSNLIFVAEVYLG-H 814

  Fly  1675 NVDVNIPDSEGRTALHVAAWQGH---ADMVKTLIEAGADVNSMDLEARTPLHSCAWQGNHDVMNI 1736
            ..:.:..|:.|||.:||.|....   |.|:|.:  .|.:..::|...||.|.:..| ..|..:::
Worm   815 GANSSDSDAHGRTCVHVVASTNDVAAAKMLKRI--GGVNFEAVDRGGRTALMTAVW-AKHVAISV 876

  Fly  1737 LLY--YGALADHACKQGATALGISAQEGHEKCVIALLQFGANPYKSDHCGRTPIKLAAKSSRTSI 1799
            .|.  .|...:...:||||||.|:||.|....|..||:|||.|...|..|||.:.:|..|....|
Worm   877 FLLDSCGVDPNRTDRQGATALSIAAQIGDRDLVNLLLKFGAEPEIKDSMGRTAMDVAMISGNEPI 941

  Fly  1800 LKIFESYTKNEASN------PNEP------KFHAHASMLRSP 1829
            :.:.:|...:..|:      ||.|      :.....|.||.|
Worm   942 VSLLQSVNGSSGSSGIGSSVPNSPLDASKQRILKATSSLRMP 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728	21/118 (18%)
		Ank_4	1237..1291	CDD:290365	12/59 (20%)
		ANK	1266..1403	CDD:238125	46/142 (32%)
		ANK repeat	1270..1313	CDD:293786	9/48 (19%)
		Ank_2	1275..1380	CDD:289560	35/110 (32%)
		ANK repeat	1315..1347	CDD:293786	10/31 (32%)
		ANK repeat	1349..1380	CDD:293786	16/30 (53%)
		Ank_2	1354..1449	CDD:289560	38/96 (40%)
		ANK repeat	1382..1413	CDD:293786	13/30 (43%)
		ANK	1410..1538	CDD:238125	41/131 (31%)
		ANK repeat	1415..1446	CDD:293786	10/32 (31%)
		Ank_5	1438..1489	CDD:290568	17/51 (33%)
		ANK	1479..1604	CDD:238125	41/125 (33%)
		ANK repeat	1484..1515	CDD:293786	10/31 (32%)
		Ank_2	1489..1581	CDD:289560	29/92 (32%)
		ANK repeat	1517..1548	CDD:293786	13/30 (43%)
		ANK repeat	1550..1581	CDD:293786	7/30 (23%)
		Ank_2	1555..1648	CDD:289560	24/92 (26%)
		ANK	1578..1705	CDD:238125	34/129 (26%)
		ANK repeat	1617..1648	CDD:293786	7/30 (23%)
		Ank_2	1624..1715	CDD:289560	21/93 (23%)
		ANK	1645..1771	CDD:238125	36/130 (28%)
		ANK repeat	1650..1682	CDD:293786	5/31 (16%)
		ANK repeat	1684..1715	CDD:293786	10/33 (30%)
		Ank_2	1689..1781	CDD:289560	32/96 (33%)
		ANK repeat	1717..1742	CDD:293786	6/26 (23%)
		ANK repeat	1750..1775	CDD:293786	14/24 (58%)
T28D6.4	NP_499461.1	Ank_2	428..521	CDD:372319	35/110 (32%)
		ANK repeat	428..454	CDD:293786	7/25 (28%)
		ANK repeat	459..488	CDD:293786	10/29 (34%)
		ANK repeat	490..521	CDD:293786	16/30 (53%)
		PHA03095	507..>776	CDD:222980	90/272 (33%)
		ANK repeat	523..554	CDD:293786	13/30 (43%)
		ANK repeat	556..592	CDD:293786	10/35 (29%)
		ANK repeat	594..624	CDD:293786	8/31 (26%)
		ANK repeat	626..658	CDD:293786	10/31 (32%)
		ANK repeat	660..691	CDD:293786	13/30 (43%)
		PHA03095	675..>943	CDD:222980	83/273 (30%)
		ANK repeat	725..756	CDD:293786	9/31 (29%)
		ANK repeat	824..856	CDD:293786	10/33 (30%)
		ANK repeat	858..890	CDD:293786	7/32 (22%)
		ANK repeat	892..923	CDD:293786	17/30 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166411
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BFJC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto17575
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3509
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.670