Protein Alignment CG10011 and rols

DIOPT Version :10

• Sequence 1: NP_651624.2
• Gene: CG10011 / 43387
• FlyBaseID: FBgn0039590
• Length: 2119
• Species: Drosophila melanogaster
• Sequence 2: XP_061496536.1
• Gene: rols / 1274089
• VectorBaseID: AGAMI1_004922
• Length: 2031
• Species: Anopheles gambiae
• Alignment Length: 1982
• Identity: 409/1982 - (20%)
• Similarity: 666/1982 - (33%)
• Gaps: 634/1982 - (31%)

  Fly     6 DNDNLRNDIYENLPCQAMYNDSVRKMQQQKSSTQTVSSNHNPNANSIGNCDSTSVINKNHPPPVN 70
            |||.|.::       .|:|....|||....||...:|...:|...     :.:.:....|...:.
Mosquito   472 DNDILSSN-------GAIYQPLSRKMHGYGSSNHLMSPLGSPQPQ-----NRSQMRTNGHFSSIY 524

  Fly    71 NMPKEMLYATPLRKSDRYKSGDRTRHVATGNAETKLFNFRDSNRLASARNGNPVQVTDLDADEDD 135
            ..|.::     |..::|||..||......|.        :..:..||...|
Mosquito   525 QSPSDI-----LGTAERYKLKDRPPKCPPGG--------KTESHYASITTG-------------- 562

  Fly   136 AQGDGVDGCGSTSALVGGSKYSSQPSAGTANQHLEDRRILNFLKDTTQLQKKLEITGRDCPNASF 200
                        |..|.||.:..||..|          ::..|:..:.|....|||...|.....
Mosquito   563 ------------STGVAGSTHHQQPGYG----------MMKPLQQRSALNSSSEITSSTCATPPQ 605

  Fly   201 SNLAREEHFANLVQQNFPQDVAHHANGETNGGSAPEEDGQEAAGGLKTQPTEDTDGNLEALMQRK 265
            :   |...|:       |:::........:.|:|.:
Mosquito   606 N---RRRLFS-------PKNLRSPFGYRRSNGNAAD----------------------------- 631

  Fly   266 VSPDKEVNGLVHSAGVEPNNRIVSTVYIHREW--VLKKIALCLEQRTAGKKSGPVALGGAASSSY 328
               :..::||.         .:::....||..  ...||:..:..||.|..|.....|...|||
Mosquito   632 ---NSTLSGLA---------SLLNPATFHRATTAAASKISRSMALRTTGGLSRDGGGGSGGSSS- 683

  Fly   329 VSARAKAAAISSSSYNGCLVLGSNGSGKTSICQAIMKGNSGTKGILNRKLLACYLIESQNPECHS 393
                  ......|.:|   :|.|:|.....|.:.....|.|.|  .:|..|.           .|
Mosquito   684 ------GGVGGGSGFN---LLASHGPPMNGISKRQRNANDGHK--FHRLSLG-----------SS 726

  Fly   394 LSLFMRKIVLQLLSHASLISRDESQRIIDEGFSFL------RDEAQQQEFKLDEAMNNISLSENA 452
            .|:...||.....:.|:.::...:|...|||.:..      :.::.|.|.:       :.|....
Mosquito   727 ASMVFGKIKSLWSAQATTVNAGLNQLADDEGGNVKPLVMNGKSKSSQDELQ-------VRLGFFL 784

  Fly   453 EELLIEELKRGASECDTKELDNFQSQRTSTVNKAARTTLTRQQSEPAPLQAMDAVNSDEKTGSNY 517
            |......|:.....|.:  |.:..:...||:..::...::|...||.|..     ...|..||
Mosquito   785 ENNTRRNLRAPNQSCSS--LTSANTSPVSTLTGSSEADVSRVLQEPNPYH-----TGCESIGS-- 840

  Fly   518 GTHPPKRASRERGDTEQDKDMGSEKEQKQSQEPKETPKSSPAKSKSKIPVKRGRSGSGV----LS 578
                                |.|..||..:       .|||...:..  |...:|||.|    ..
Mosquito   841 --------------------MMSISEQSNA-------SSSPVSRRHS--VTTSQSGSNVDDLLAF 876

  Fly   579 PSKLATISNGGQSIQQGGGEDIADLNTDQEKHEIEAAIKDDKVEEPQANNEDKKEDKPEADKELN 643
            .|:..|:....:|.|                  |:..| |.|:...|...:.:::
Mosquito   877 KSRRTTVRRSARSGQ------------------IKGPI-DPKIRFAQYRQQHQQQ---------- 912

  Fly   644 DQLKEEL-------DKSSQEP------KEEETKEEATADSSAEP----------------LIDFT 679
            .||:::|       :..:.||      :....:|.|||..|.:.                |:...
Mosquito   913 QQLQQQLTLKPLFFEVPTHEPNPLFVGRHWLVRELATAIQSTDSPGVLLSGNLGTGKTALLLQLV 977

  Fly   680 ESNVNGKQEEPQLKP--------PVPGEKPRI----------------STNTLPPPLPK--TKSC 718
            |.:..|:::|..::.        .|..::.|.                ||..:|..:..  .:.|
Mosquito   978 EYSCFGRRKELPIQENDGIYCQINVAHDRLRTLASHVVAYHFCQADNNSTCLIPDFVHSLAAQLC 1042

  Fly   719 RTIIADGYYELLLSNPEILECLSVDNIEKNPDECFKKAFLFPLLEL-----TPPKTALLLLIDSI 778
            :......|:|.||....:...|||.....||:.......|.||..|     .|.|.. ::|:|::
Mosquito  1043 QAPQLAAYHEFLLGEHALQHALSVKECIANPERAMTMGILEPLAALRRTGKIPAKNC-VILVDAL 1106

  Fly   779 DE---NYINEGNLISTLKGGRGTVTNHKSRNVAELLSNHIHLFPKWLFLVCTTKKQTKQITKMFT 840
            .|   :..:.|:.:::.               .:.:|.|   ||.||.::.|.:.|..:..|...
Mosquito  1107 CEAEYHRPDHGDTVASF---------------LQRMSEH---FPPWLKVIATIRTQMLEFCKGLP 1153

  Fly   841 GFKKITLDDLRKSHVV-KDVQEYIINRLN--SDFKDSIMLTKEIIE-SLH-----QLYIKSNGCI 896
             :.|::||....:.:: ||:.|||..|:|  ...:.::...||||. |.|     .|...|.|..
Mosquito  1154 -YTKMSLDSWATNEMLQKDILEYITFRINQSQSIQHNVAGGKEIINTSAHFKFAQHLLALSKGSF 1217

  Fly   897 LY----LEKVLHG---IKDNFFSFREIKLIPCTLNGLYLYICQKSFNKK-----QYMKIRPLLNV 949
            |:    |:.:..|   ||.:.|     |::|.:|..::|.    :||.:     .|.:|..:|.|
Mosquito  1218 LFAKLTLDLIERGNLVIKSSSF-----KVLPVSLAQIFLL----NFNLRFPTATAYDRISNILAV 1273

  Fly   950 LLASSGYVDKLFLFNCLR--------------------THNYTIDCQEFEKRLQLMRNILAYDSN 994
            .||:...:....:|..|.                    |....||..||..|.:.:...|
Mosquito  1274 CLAALYPLTLTEIFYSLNALIASGESPADSESGSEPDGTGGGMIDWDEFLCRFKTLTGFL----- 1333

  Fly   995 AQRL----KIFHNSFADWLV--DVKFATKKFICDVNEGHVMISMYYLLVADTLCANTVRRFAYHL 1053
            .:||    ..||.||.:||:  |...:| ||:||:..||..|::....:...|.........:|:
Mosquito  1334 VKRLDDTYMFFHPSFREWLIRRDDGEST-KFLCDLRNGHAGIALRLSRLQAPLDPEQALELGHHI 1397

  Fly  1054 IRSGEYLTSRHVDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFLPKTRAMLERFLA 1118
            :                                                       :|.|.|...
Mosquito  1398 L-------------------------------------------------------KAHLYRNAP 1407

  Fly  1119 SELSEPFAQFLCDFFKPSLPTDAKMLKLLIETGINNAESQNSCESSLMSPELSEKSQNIDFELAD 1183
            |..|               |.|.:...:...||         |.||.::...:..|.|:  :::.
Mosquito  1408 SHQS---------------PRDLQAYWVASVTG---------CVSSALTTLRNVYSPNV--KVSR 1446

  Fly  1184 LLLSSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHIELHKGKALIHILANDGNH 1248
            |||           .||:..:|..|...|
Mosquito  1447 LLL-----------LAGASPDHVTPFLGS------------------------------------ 1464

  Fly  1249 QLLERALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPCNDGTGRMKRVDVNHAD 1313
                       :||            |.|||..|.|.:|.|||.|.            ..|...:
Mosquito  1465 -----------API------------LCIAAHEGILPMVNLLLEFG------------ASVEQTN 1494

  Fly  1314 RDGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLI------ES 1372
            ..|.|||..||..||.:|||.|:|..|. :...|...|.||..||.:|...::|.|:      .|
Mosquito  1495 SQGCTPLILASARGHCDVVRQLVAAGAF-LGQTDTSQRCALVHAAIAGRLQVVKYLVACDWLPRS 1558

  Fly  1373 GADVNSVDRQGRTSLIAASYMGHYDIVEILLENG-ANVNHLD-LDGRSALCVAALCGSSGYSKVI 1435
            |::..::::..:.:|.||:..|:.||||.||:.| ..||.|| :.|.:||..|.   ::|:::.|
Mosquito  1559 GSNDVTLEQAAQQALTAAAGQGNTDIVEDLLDMGEVQVNRLDVITGETALTTAC---ANGHTETI 1620

  Fly  1436 STLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACTAGHATV 1500
            ..||:.||:|:..:...|:|||::..||:..:.|.||::.||.:..:...:|.|..|...||..:
Mosquito  1621 VILLNRGASTEVRNRKEMAPLLIAVKEGHWAIVERLLQHPADCEQTEANSKTALMIAAEEGHVGI 1685

  Fly  1501 VKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYAAFEGFHE 1565
            ::|||..|..:...|.:|.|.||....:|..:..:.||:||.|:.|.|..|.|||..||::|...
Mosquito  1686 IELLLSRGASLTAQDKDGLTALSWACLRGKQQAAKCLLERGADKQHADGTGRTPLDLAAYQGSAS 1750

  Fly  1566 VCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALL------------------DIHSSFVD 1612
            :...||:.||:|:..|..|...|..|.....:..||..|                  :|....::
Mosquito  1751 LVQMLLDHGAQIEHVDINGMRPLDRAIACRNVQVVQVFLKRGAKLGPATWAMANGKPEIMLILLN 1815

  Fly  1613 QKAHDGKTAFRLACLEGHMDTVEFLLK----------------FCCDV--------------NSK 1647
            :...||.|.:|...|:......::.||                .|..|              ||.
Mosquito  1816 KLLEDGNTLYRKNRLQEASHRYQYALKKIPSAPSTGGDVNGNGGCTMVTDPLTGGPVPDSNNNSH 1880

  Fly  1648 DADSRTTLYILALENKLEIVKYLLDMTNV-----DVNIPDSEGRTALHV--AAWQGHADMVKTLI 1705
            .::|....:     .:|.. .:||:::..     ||.......|.|:.:  :|:.|:....|.|:
Mosquito  1881 SSNSNVATF-----QQLRF-NFLLNLSRCKRKMNDVAEAIELARQAIEIKPSAYDGYYARAKALM 1939

  Fly  1706 EAG---------------ADVNSMDL-EARTPLHSCAWQGNHDVMNILLYYGALADHACKQGATA 1754
            |.|               |...:.:: |..|.||....:....|         :||       ||
Mosquito  1940 EQGSYGEALRDASAALARAQPTTAEIRETLTRLHGDLQKRQMQV---------IAD-------TA 1988

  Fly  1755 LGISAQEGHEKCVIALLQFGANPYKSDHCGRT 1786
            ....|..|.......:...|:....|.|.||:
Mosquito  1989 NSALASVGLSTVATPMESVGSTRSSSVHSGRS 2020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	ANKYR	1236..1489	CDD:440430	77/260 (30%)
		ANK repeat	1270..1313	CDD:293786	12/42 (29%)
		ANK repeat	1315..1347	CDD:293786	14/31 (45%)
		ANK repeat	1349..1380	CDD:293786	10/36 (28%)
		ANK repeat	1382..1413	CDD:293786	13/31 (42%)
		ANK repeat	1415..1446	CDD:293786	10/30 (33%)
		ANKYR	1469..1788	CDD:440430	89/389 (23%)
		ANK repeat	1484..1515	CDD:293786	9/30 (30%)
		ANK repeat	1517..1548	CDD:293786	11/30 (37%)
		ANK repeat	1550..1581	CDD:293786	12/30 (40%)
		ANK repeat	1617..1648	CDD:293786	11/60 (18%)
		ANK repeat	1650..1682	CDD:293786	6/36 (17%)
		ANK repeat	1684..1715	CDD:293786	9/47 (19%)
		ANK repeat	1717..1742	CDD:293786	5/24 (21%)
		ANK repeat	1750..1775	CDD:293786	4/24 (17%)
rols	XP_061496536.1	None