Protein Alignment CG10011 and LOC1274056

DIOPT Version :10

• Sequence 1: NP_651624.2
• Gene: CG10011 / 43387
• FlyBaseID: FBgn0039590
• Length: 2119
• Species: Drosophila melanogaster
• Sequence 2: XP_313120.6
• Gene: LOC1274056 / 1274056
• VectorBaseID: AGAMI1_002206
• Length: 2274
• Species: Anopheles gambiae
• Alignment Length: 2408
• Identity: 1245/2408 - (51%)
• Similarity: 1554/2408 - (64%)
• Gaps: 437/2408 - (18%)

  Fly    12 NDIYENLPCQAMYNDSVRKMQQQKSSTQTVSS--------------NHNPNA----NSIGNCDST 58
            :||||||||..  ::::|......::...|||              .:.|.|    :..|...:.
Mosquito     4 DDIYENLPCHT--DEALRNGNGTSTTGNRVSSVMMEGGGGGGVAGGRNRPTAEGDEHGEGKVQNN 66

  Fly    59 SVINKNHPPPVNNMPKEMLYATPLRKSDRYKSGDRTRHVATGNAETKLFNFRDSNRLASARNGNP 123
            ..:|.          |:|||||||:||:|               ..|:.     |...:.:|||
Mosquito    67 LALNS----------KDMLYATPLKKSER---------------PVKVL-----NNAPAMQNGN- 100

  Fly   124 VQVTDLDADEDDAQGDGVDGCGSTSALVGGSKYSSQPSAGT-----------ANQHLEDRRILNF 177
                            ||.|        ||.:.::..:|||           .|..||||||.:|
Mosquito   101 ----------------GVGG--------GGRQNTATANAGTFSGEAERDTKIINAELEDRRIRDF 141

  Fly   178 LKDTTQLQKKLEITGRDCPNASFSNLAREEHFANLVQQNFPQD----VAHH----ANGETNGGSA 234
            ||||:|:.||:|: .:...:::||.|||:||||:|||:|....    ..||    .:|....|..
Mosquito   142 LKDTSQMHKKIEL-HKTYQSSNFSYLARKEHFADLVQRNVNSSNGAAADHHPEPAGDGADAAGDE 205

  Fly   235 PEEDGQ---EAAGGLKTQPTEDTDGNLE-------------------------------ALMQRK 265
            |:....   .||||.||...|:.|.||:                               |..||.
Mosquito   206 PDSSAALAVAAAGGYKTLAGEEEDKNLDLDINESLNELEARCNEKLEMLAKLNRTRSSTATEQRS 270

  Fly   266 VSPDKE----------VNGLVHSAGVEP----------------------NN------------R 286
            ...:::          |.|....|||.|                      ||            .
Mosquito   271 QEDNEQQADLLGAQLMVGGDEGDAGVVPKPSAPPLSALTTERGSKAGGGSNNLTDPNAGGAGSGE 335

  Fly   287 IVSTVYIHREWVLKKIALCLEQRTAGKKSGPVALGGA-------------ASS-------SYVSA 331
            .:.:.:::|||||||||:|||||.:.|...||...||             |||       .|.:.
Mosquito   336 AIISAHLNREWVLKKIAMCLEQRISKKPVPPVPTVGAGVTQSTEGAPTPSASSVPPAGPGGYFAR 400

  Fly   332 RAKAAAISS-----------SSYNGC-----LVLGSNGSGKTSICQAIMKGNSGTKGILNRKLLA 380
            ..:|||.|.           ...||.     ||||||||||||||..|::|.|||||:|||:|||
Mosquito   401 SGQAAAASGVPPTDGGGHHRGGENGLPSLGYLVLGSNGSGKTSICNDIIEGTSGTKGMLNRRLLA 465

  Fly   381 CYLIESQNPECHSLSLFMRKIVLQLLSHASLISRDESQRIIDEGFSFLRD--------------- 430
            ||.:.||||||||||:|:|.::||:|||:|.::...|..:.......|.:
Mosquito   466 CYFVNSQNPECHSLSMFIRSVILQILSHSSYVNSTGSCGVGPPELINLSEVSVEANELQPVNTSN 530

  Fly   431 ----EAQQQEFKLDEAM-NNISLSENAEELLIEELKRGASECDTKELDNFQSQRTS-TVNK---- 485
                ||.||:.|.:..: .....|..:.:....:...|::|...|||::  :.||. .:|:
Mosquito   531 DCLPEADQQQLKAEPVLPQPAGESHGSNQPATMDATDGSNEAVDKELED--AIRTEMKINERVAE 593

  Fly   486 --AARTTLTRQQSEPAPLQAMDAVNSD-EKTGSNYGTHPPKRASRERGDTEQDKDMGSEKEQKQS 547
              :.|..::||||||     :::::.| |:....|.||||..|....|:...::....||..|.:
Mosquito   594 FCSNRKKVSRQQSEP-----VESLSRDREQPNYPYKTHPPAVAKAGTGNAGAEESNDDEKLDKAT 653

  Fly   548 QEPKETPKSSPAKSKSKIPVKRGRSGSGVLSPSKLATISNGG----------------------- 589
            ..|     ..||| .||||:   ..||.:.||.|::.....|
Mosquito   654 MSP-----GRPAK-VSKIPI---AIGSTIRSPKKMSPTKEDGSGKQEQLEHHPGTKPTPEEEEQD 709

  Fly   590 QSIQQGGGEDIADLNTDQEKHEIEAAIKDDKVEEPQANNEDKKEDKPEADKELNDQLKEELDKSS 654
            .:|.:||||.||           |..:.|.|:.      ||::||.         .:|.::.:.:
Mosquito   710 DTILEGGGEAIA-----------EGDMSDIKLV------EDEEEDA---------VVKSDVSEKA 748

  Fly   655 QEPKEEETKEEATADSSAEPLIDFTESNVNGKQEEPQLKPPVPGEKPRISTNTLPPPLPKTKSCR 719
            ::.:...|.|:..|.:.:|            ::::..::...|.|      .::||||||:|:||
Mosquito   749 KQSEPMVTPEQPAARNDSE------------EKKQHTMRTTKPME------TSIPPPLPKSKNCR 795

  Fly   720 TIIADGYYELLLSNPEILECLSVDNIEKNPDECFKKAFLFPLLELTPPKTALLLLIDSIDENYIN 784
            .:|||||||:|||||:|.|.|:||:||||||:|||||.|||||||.|||.||||||||||||||.
Mosquito   796 QVIADGYYEMLLSNPDIFESLTVDSIEKNPDDCFKKAILFPLLELCPPKNALLLLIDSIDENYIQ 860

  Fly   785 EGNLISTLKGGRGTVTNHKSRNVAELLSNHIHLFPKWLFLVCTTKKQTKQITKMFTGFKKITLDD 849
            :|||||||||.:.|    ||||:||||||||||.|||||:|||.|||.|.|||:||||||:||||
Mosquito   861 DGNLISTLKGKQVT----KSRNIAELLSNHIHLMPKWLFMVCTAKKQNKNITKLFTGFKKLTLDD 921

  Fly   850 LRKSHVVKDVQEYIINRLNSDFKDSIMLTKEIIESLHQLYIKSNGCILYLEKVLHGIKDNFFSFR 914
            |||||||||||:|||||||:||: .|.|||:|||||:|||||||||:|||.|||:||::|||:||
Mosquito   922 LRKSHVVKDVQQYIINRLNTDFR-GINLTKDIIESLNQLYIKSNGCLLYLYKVLNGIRENFFTFR 985

  Fly   915 EIKLIPCTLNGLYLYICQKSFNKKQYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNYTIDCQEFE 979
            ||||||||||||||||||||||||||.||||:|||||..:.||||.|::|||||||||::.::||
Mosquito   986 EIKLIPCTLNGLYLYICQKSFNKKQYSKIRPILNVLLVCNSYVDKYFIYNCLRTHNYTLEMEDFE 1050

  Fly   980 KRLQLMRNILAYDS-NAQRLKIFHNSFADWLVDVKFATKKFICDVNEGHVMISMYYLLVADTLCA 1043
            :||:|||||:.|.. |...::||||||.|||:||||:||||:||:||||||:||||.:|||.:|.
Mosquito  1051 RRLELMRNIVEYSPLNPCAVRIFHNSFCDWLIDVKFSTKKFLCDLNEGHVMVSMYYTVVADEICP 1115

  Fly  1044 NTVRRFAYHLIRSGEYLTSRHVDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFLPK 1108
            |.:|.:.||||::||||||::|||||:|:|||::.|||||||||.:||||.||.:.:.|:|...:
Mosquito  1116 NKLRLYLYHLIKTGEYLTSKNVDLDLLLILLETKSNLSDCFYTNLLNCCAMCEDECRNDINLSAR 1180

  Fly  1109 TRAMLERFLASELSEPFAQFLCDFFKPSLPTDAKMLKLLIETGINNAESQNSCESS-LMSPELSE 1172
            |:.||:|||..:|.:.|..||.|||||:||||.|:||||||||||||::..||||| :.||.||:
Mosquito  1181 TKYMLDRFLNGQLGDDFMIFLNDFFKPNLPTDCKVLKLLIETGINNADTALSCESSAINSPVLSD 1245

  Fly  1173 KSQNIDFELADLLLSSEKSCLMETQRA-------------------------------------- 1199
            :|||||.|||:||:||||||..|.|::
Mosquito  1246 RSQNIDSELAELLISSEKSCQQELQKSINLELLDCTGAVGGGGGCGGMLDGALLARDGGAGRVSA 1310

  Fly  1200 ----------------------GSPSEHSEPPAESQDENASSTLHQLSDSHHIELHKGKALIHIL 1242
                                  |..|...:..::.|::...|.:.  .|....|:||||||||||
Mosquito  1311 ELARHRYSAGPSITSGGVGGGDGGSSALGDSKSDIQNDRVGSGVQ--CDMFEGEMHKGKALIHIL 1373

  Fly  1243 ANDGNHQLLERALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPCNDGTGRMKRV 1307
            ||:|||.||||||||||.||||||||.||||||||||||||.|:|||||::.||..|||||.:.:
Mosquito  1374 ANEGNHTLLERALNACKDPIDLEIEDLNGQTALNIAARNGHQEIVKLLLTYKQPLRDGTGRYRMI 1438

  Fly  1308 DVNHADRDGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLIES 1372
            |||||||||||||||||||||:|||:|||....|.||.||||||||||||||||:|||:|:|||:
Mosquito  1439 DVNHADRDGWTPLRSASWGGHTEVVKLLIETGVCAIDRADKEGRTALRAAAWSGNEDIVKILIEA 1503

  Fly  1373 GADVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLDGRSALCVAALCGSSGYSKVIST 1437
            ||:|||:|:||||||||||||||||||||||||||:|||.|||||:||||||||||||||:||||
Mosquito  1504 GANVNSIDKQGRTSLIAASYMGHYDIVEILLENGADVNHTDLDGRNALCVAALCGSSGYSRVIST 1568

  Fly  1438 LLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACTAGHATVVK 1502
            ||::||||||.||:|||||||||||||||:|||||||.||||:||.|||||||||||:|||.|||
Mosquito  1569 LLEYGANTDQTDNEGMSPLLVSSFEGNAEICELLLENGADPDMADNMGRTPLWAACTSGHANVVK 1633

  Fly  1503 LLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYAAFEGFHEVC 1567
            |||||||||||||||||||||:.|||||:|||||||||||||||||||||||||||||||:.::|
Mosquito  1634 LLLFWGCGIDCMDSEGRTVLSVAAAQGNLETVRQLLDRGLDETHRDNAGWTPLHYAAFEGYADIC 1698

  Fly  1568 LQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACLEGHMD 1632
            :|||||||||||||||||.|||||||||....::|:|:||...:||:||||||||||||||.|.:
Mosquito  1699 VQLLESGAKIDECDNEGKAALHLAAQEGHNAVMEAILNIHRPCIDQRAHDGKTAFRLACLEEHFE 1763

  Fly  1633 TVEFLLKFCCDVNSKDADSRTTLYILALENKLEIVKYLLDMTNVDVNIPDSEGRTALHVAAWQGH 1697
            .::.||||.||:||||||||||||||||||||:.||:||:.:|.|||||||||||||||:|||||
Mosquito  1764 CIQTLLKFGCDINSKDADSRTTLYILALENKLKAVKFLLEYSNADVNIPDSEGRTALHVSAWQGH 1828

  Fly  1698 ADMVKTLIEAG-ADVNSMDLEARTPLHSCAWQGNHDVMNILLYYGALADHACKQGATALGISAQE 1761
            |:|||.||..| ||||:||||:|||||||||||||:||.:||||||:.|||||||||||||||||
Mosquito  1829 AEMVKLLITLGNADVNAMDLESRTPLHSCAWQGNHEVMQLLLYYGAVPDHACKQGATALGISAQE 1893

  Fly  1762 GHEKCVIALLQFGANPYKSDHCGRTPIKLAAKSSRTSILKIFESYTKNEASNPNEPKFHAHASML 1826
            ||||||..||::|||||||||||||||||||||:|.::|:|.|::|||:.....  ..|.|.: |
Mosquito  1894 GHEKCVSYLLKYGANPYKSDHCGRTPIKLAAKSNRNNVLRILENFTKNDLDCGK--MMHPHLN-L 1955

  Fly  1827 RSPDQ-PPALPLHQNLAP---YPAHASASSVCSAATTATVHNGSHLHVLNASSSTHSSNNFYQNT 1887
            :|||: ||...:| |.:|   ||.:.:.....|......:.|.|..: .|.:|||..:||||:||
Mosquito  1956 KSPDELPPCSSIH-NPSPSSGYPNNPNLLMPASGGGGPAMLNVSSTN-SNTTSSTTQNNNFYENT 2018

  Fly  1888 MQSDTSSLHKRKSVISSQSTGSSNDQAPLTFTQQLQRQSK-LSSRNNLMVNSKH-------ASSS 1944
            |.||||||.|||||||||||||||:|||::||||||:.|: .:|:::.:|..:|       .|||
Mosquito  2019 MHSDTSSLQKRKSVISSQSTGSSNEQAPMSFTQQLQKHSRHHNSKSHHIVQQQHQPHHQQQTSSS 2083

  Fly  1945 GAAGHKSSGGGGGAQRHSQVLPDLSEHQ--LASNM---TNEADMYDMECMSPLYATPPHSPSSEL 2004
            ..|...:       ::||||||::.|:|  :|||:   .|:||::|:.||||||||||||||||:
Mosquito  2084 SVAKFSN-------KKHSQVLPNVEEYQANIASNIRINPNDADLFDLGCMSPLYATPPHSPSSEI 2141

  Fly  2005 SSPGQ------LPGLNAFVDDERAGTSSGGGAKLP-DNHFARDTHMRIILG-NLKEN---QPSSS 2058
            |||||      |..|....::.....|:......| ||||||||||||||| |.||:   |.:|.
Mosquito  2142 SSPGQNQPPSSLALLGKQFEEMNISLSNNSTIMNPHDNHFARDTHMRIILGNNQKESGQLQGASG 2206

  Fly  2059 G------KSKRSGVSSNPAMRLIRSRFDAASQLIRRTNNILSSS-SNQGSSSIGVKSGTFQWRKE 2116
            |      .|||||:::||||||||:|.|:|:||||||||:|||| :|||||||||||||||||||
Mosquito  2207 GAGGGGKSSKRSGIATNPAMRLIRNRIDSAAQLIRRTNNMLSSSGNNQGSSSIGVKSGTFQWRKE 2271

  Fly  2117 SQM 2119
            |||
Mosquito  2272 SQM 2274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	ANKYR	1236..1489	CDD:440430	210/252 (83%)
		ANK repeat	1270..1313	CDD:293786	31/42 (74%)
		ANK repeat	1315..1347	CDD:293786	23/31 (74%)
		ANK repeat	1349..1380	CDD:293786	25/30 (83%)
		ANK repeat	1382..1413	CDD:293786	29/30 (97%)
		ANK repeat	1415..1446	CDD:293786	26/30 (87%)
		ANKYR	1469..1788	CDD:440430	259/319 (81%)
		ANK repeat	1484..1515	CDD:293786	28/30 (93%)
		ANK repeat	1517..1548	CDD:293786	27/30 (90%)
		ANK repeat	1550..1581	CDD:293786	25/30 (83%)
		ANK repeat	1617..1648	CDD:293786	21/30 (70%)
		ANK repeat	1650..1682	CDD:293786	24/31 (77%)
		ANK repeat	1684..1715	CDD:293786	24/31 (77%)
		ANK repeat	1717..1742	CDD:293786	20/24 (83%)
		ANK repeat	1750..1775	CDD:293786	20/24 (83%)
LOC1274056	XP_313120.6	None