DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10011 and ankrd42

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	XP_002942124.2	Gene:	ankrd42 / 100498077	XenbaseID:	XB-GENE-5888011	Length:	514	Species:	Xenopus tropicalis

Alignment Length:	500	Identity:	117/500 - (23%)
Similarity:	187/500 - (37%)	Gaps:	151/500 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1354 LRAAAWSGHEDILKLLIESGADVNSVDRQGR-TSLIAASYMGHYDIVEILLENGANVNHLDLDGR 1417
            :..|...|..:.|..:::||..:|..|...: |.|..|::.|..:.:..||.:||:|:.:...|.
Frog    22 IHEAVRGGDVEQLAAIVQSGTGINDPDPLHKFTPLHWAAHSGSLECLHWLLWHGADVSDVTTRGW 86

  Fly  1418 SALCVAALCGSSGYSKVISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVC-ELLLENAADPDLA 1481
            :|..:||:.|.                                     :.| :.|:.|.||....
Frog    87 TAAHLAAIRGQ-------------------------------------DACMQALIVNGADLSAK 114

  Fly  1482 DFMGRTPLWAACTAGHATVVKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETH 1546
            |.       ..|...|                          :.||.|:..|::.:|..|:|...
Frog   115 DD-------RHCCPAH--------------------------LAAAHGHSFTLQSVLRSGVDINS 146

  Fly  1547 RDNAGWTPLHYAAFEGFHEVCLQLL-ESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSS- 1609
            .|..||.|:|||||.| ...||||| ..||.:::.|..|....||||.||.|||::.|:...||
Frog   147 SDRTGWKPVHYAAFHG-RLGCLQLLFRWGATLEDADLNGNIPAHLAAMEGHLHCLKFLVSKASSV 210

  Fly  1610 --FVDQKAHDGKTAFRLACLEGHMDTVEFLLKFCCDVNSKDADSRTTLYILALENKLEIVKYLLD 1672
              .::....:|:|...||                           ..||      |..||:| :|
Frog   211 TRVLEATNMNGETPKDLA---------------------------RKLY------KDNIVQY-ID 241

  Fly  1673 MTNVDVNIPDSEGRTAL--HVAAWQGHADMVKTLIEAG-ADVNSMDLEARTPLHSCAWQGNHDVM 1734
            ....:.:.||.:...|.  ||||::|....::.|:|:| .::|..|.:..||||..|.||..:
Frog   242 GVEYERDHPDEQENLAFPAHVAAFKGDLVTLRKLVESGIININERDDKGATPLHKAAGQGQLE-- 304

  Fly  1735 NILLYYGALADHACKQGATALGISAQEGHEKCVIALLQFGANPYKSDHCGRTPIKLAAKSSRTSI 1799
                                           |:..||:.||:...::..|.||..:|.:.::.:.
Frog   305 -------------------------------CLQWLLEMGADYNITNEAGETPKDVAKRFAKLAA 338

  Fly  1800 LKIFESYTKNEAS----NPNEPKFHAHASMLRSPDQPPALPLHQN 1840
            :|:.......|.|    |..:|.:.....:..|.|.|..|.|.::
Frog   339 VKLLGGNVAGEDSDEELNDEDPAYFERHGVEGSTDHPDYLSLSES 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728
		Ank_4	1237..1291	CDD:290365
		ANK	1266..1403	CDD:238125	11/49 (22%)
		ANK repeat	1270..1313	CDD:293786
		Ank_2	1275..1380	CDD:289560	6/25 (24%)
		ANK repeat	1315..1347	CDD:293786
		ANK repeat	1349..1380	CDD:293786	6/25 (24%)
		Ank_2	1354..1449	CDD:289560	21/95 (22%)
		ANK repeat	1382..1413	CDD:293786	9/31 (29%)
		ANK	1410..1538	CDD:238125	17/128 (13%)
		ANK repeat	1415..1446	CDD:293786	5/30 (17%)
		Ank_5	1438..1489	CDD:290568	6/51 (12%)
		ANK	1479..1604	CDD:238125	38/125 (30%)
		ANK repeat	1484..1515	CDD:293786	2/30 (7%)
		Ank_2	1489..1581	CDD:289560	26/92 (28%)
		ANK repeat	1517..1548	CDD:293786	7/30 (23%)
		ANK repeat	1550..1581	CDD:293786	16/31 (52%)
		Ank_2	1555..1648	CDD:289560	31/96 (32%)
		ANK	1578..1705	CDD:238125	33/131 (25%)
		ANK repeat	1617..1648	CDD:293786	4/30 (13%)
		Ank_2	1624..1715	CDD:289560	21/93 (23%)
		ANK	1645..1771	CDD:238125	28/128 (22%)
		ANK repeat	1650..1682	CDD:293786	7/31 (23%)
		ANK repeat	1684..1715	CDD:293786	10/33 (30%)
		Ank_2	1689..1781	CDD:289560	22/94 (23%)
		ANK repeat	1717..1742	CDD:293786	7/24 (29%)
		ANK repeat	1750..1775	CDD:293786	3/24 (13%)
ankrd42	XP_002942124.2	ANK repeat	22..48	CDD:293786	6/25 (24%)
		PHA02874	29..>359	CDD:165205	110/467 (24%)
		ANK repeat	50..82	CDD:293786	9/31 (29%)
		ANK repeat	84..115	CDD:293786	10/67 (15%)
		ANK repeat	150..181	CDD:293786	16/31 (52%)
		ANK repeat	183..213	CDD:293786	13/29 (45%)
		ANK repeat	289..320	CDD:293786	12/63 (19%)
		Smc	376..>472	CDD:224117	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920