DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10011 and zfp1

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	XP_017945878.1	Gene:	zfp1 / 100493692	XenbaseID:	XB-GENE-6465737	Length:	507	Species:	Xenopus tropicalis

Alignment Length:	389	Identity:	78/389 - (20%)
Similarity:	131/389 - (33%)	Gaps:	147/389 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 GLKTQPTEDTDGNLEALMQRKVSPDKEVNGLVHSAGVEPNNRIVS----TVYIHREWVLKKIALC 305
            |:..:||:...||.:        ||     |:|       .||:|    .:|:          |.
Frog     2 GISQEPTDPVMGNQD--------PD-----LLH-------QRILSLTLEIIYL----------LT 36

  Fly   306 LEQRTAGKKSGPVA---------LGGA----ASSSYVSARAKAAAISSSSYNGCLVLGSNGSGKT 357
            .|..|..||||..|         ||||    .:.:..:..|..:|:...:....|.|.||
Frog    37 GEGYTVTKKSGDGAPPQTCTDCMLGGACRHHVTPTVGALHAPGSALQKENAKRILELISN----- 96

  Fly   358 SICQAIMKGNSGTKGILNRKLLACYLIESQNPECHSLSLFMRKIVLQLLSHASLISRDESQRIID 422
             |.|.:    :|...|                .|..:||:..      |.....:..::|:.:
Frog    97 -IIQLL----TGEVAI----------------RCEDVSLYFS------LEEWQYLKGNKSRYL-- 132

  Fly   423 EGFSFLRDEAQQQEFKLDEAMNNISLSENAE----------ELLIEELKRGASECDTKELDNFQS 477
            ||   :....||.:...::      :..:||          |::.||    .|..::..|.|..:
Frog   133 EG---MEGSVQQTDCPKED------VGSDAEPLWYRDREFPEIVAEE----PSLWESPTLPNTPT 184

  Fly   478 QRTSTVNKAAR---------------TTLTRQQSEPAPLQAMDAVNSDEKTGSNYGTHPPKRASR 527
            ......|:.:|               ..||||.. |.|     ..|.::...          ||.
Frog   185 APQRPPNRISRGFNEELAAWGRGKGSDPLTRQMG-PDP-----CTNPNDSLS----------ASI 233

  Fly   528 ERGDTEQDKDMGSEKEQKQSQ-------EPKE---TPKSSPAKSKSKIPVKRGRSGSGVLSPSK 581
            ...|.::::|  |.:|.|:|.       ||.|   .|:||...:.|.:.:....:.|..::|::
Frog   234 LLRDIKEEED--SWEEGKESDFSIVTVTEPMEEMPDPESSANNTFSSVTISELETTSFQVAPNR 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640	20/122 (16%)
		Methylase_S	<772..885	CDD:279728
		Ank_4	1237..1291	CDD:290365
		ANK	1266..1403	CDD:238125
		ANK repeat	1270..1313	CDD:293786
		Ank_2	1275..1380	CDD:289560
		ANK repeat	1315..1347	CDD:293786
		ANK repeat	1349..1380	CDD:293786
		Ank_2	1354..1449	CDD:289560
		ANK repeat	1382..1413	CDD:293786
		ANK	1410..1538	CDD:238125
		ANK repeat	1415..1446	CDD:293786
		Ank_5	1438..1489	CDD:290568
		ANK	1479..1604	CDD:238125
		ANK repeat	1484..1515	CDD:293786
		Ank_2	1489..1581	CDD:289560
		ANK repeat	1517..1548	CDD:293786
		ANK repeat	1550..1581	CDD:293786
		Ank_2	1555..1648	CDD:289560
		ANK	1578..1705	CDD:238125
		ANK repeat	1617..1648	CDD:293786
		Ank_2	1624..1715	CDD:289560
		ANK	1645..1771	CDD:238125
		ANK repeat	1650..1682	CDD:293786
		ANK repeat	1684..1715	CDD:293786
		Ank_2	1689..1781	CDD:289560
		ANK repeat	1717..1742	CDD:293786
		ANK repeat	1750..1775	CDD:293786
zfp1	XP_017945878.1	KRAB_A-box	107..141	CDD:383038	8/60 (13%)
		COG5048	<262..469	CDD:227381	7/34 (21%)
		C2H2 Zn finger	324..344	CDD:275368
		C2H2 Zn finger	352..372	CDD:275368
		C2H2 Zn finger	380..400	CDD:275368
		C2H2 Zn finger	408..428	CDD:275368
		C2H2 Zn finger	436..456	CDD:275368
		C2H2 Zn finger	464..484	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010