Protein Alignment CG10011 and ankrd50

DIOPT Version :10

• Sequence 1: NP_651624.2
• Gene: CG10011 / 43387
• FlyBaseID: FBgn0039590
• Length: 2119
• Species: Drosophila melanogaster
• Sequence 2: XP_002942044.1
• Gene: ankrd50 / 100490221
• XenbaseID: XB-GENE-6045366
• Length: 1410
• Species: Xenopus tropicalis
• Alignment Length: 1483
• Identity: 546/1483 - (36%)
• Similarity: 787/1483 - (53%)
• Gaps: 293/1483 - (19%)

  Fly   727 YELLLSNPEILECLSVDNIEKNPDECFKKAFLFPLLELTPPKTALLLLIDSIDE--NYINEGNLI 789
            :|..|::|.:...|.....|:||.|.||:..|.|||.:..|..:|.:::||:||  |.:...:..
 Frog   131 FEDKLNDPSVQSLLQPGECERNPSEAFKRCVLLPLLAIKAPAQSLFMVVDSVDEGCNIVEGEHRP 195

  Fly   790 STLKGGRGTVTNHKSRNVAELLSNHIHLFPKWLFLVCTTKKQTKQITKMFTGFKKITLDDLRKSH 854
            |.|.|           .:|:||:.|...||.||.|:|:.:||::.:|||||||:||:||||||::
 Frog   196 SGLSG-----------TIADLLATHHEFFPPWLLLICSARKQSRTVTKMFTGFRKISLDDLRKAY 249

  Fly   855 VVKDVQEYIINRLNSDFKDSIMLTKEIIESLHQLYIKSNGCILYLEKVLHGIKDNFFSFREIKLI 919
            :|||||:||::||:.:......||||..|.|:||:|||:||.||||:||.|:.:||...|||:.|
 Frog   250 IVKDVQQYILHRLDQEEALRQHLTKETAEMLNQLHIKSSGCFLYLERVLDGVVENFIMLREIRDI 314

  Fly   920 PCTLNGLYLYICQKSFNKKQYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNYTIDCQEFEKRLQL 984
            |.|||||||::||:.|.:||:.|::|:|||:||:...:..:.|||.:.|.|.::..::|:::|.:
 Frog   315 PGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAACKPLTTIELFNAVWTKNMSLTMEDFQRKLDV 379

  Fly   985 MRNILAYDSNAQRLKIFHNSFADWLVDVKFATKKFICDVNEGHVMISMYYLLVADTLCANTVRRF 1049
            :..:|.......:: :||.|||:||:|||..|:|::|:..|||.|::|.|...|..|....|:.|
 Frog   380 LSKVLVEGLGNTKI-LFHYSFAEWLLDVKHCTQKYLCNAAEGHRMLAMSYTCRAKELTPIEVQEF 443

  Fly  1050 AYHLIRSGEYLTSRHVDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFLPKTRAMLE 1114
            |.|||.|...||:..:.|.:||.                    ..|..|
 Frog   444 ALHLIHSNLQLTNSELALWMILN--------------------GTCVKD---------------- 472

  Fly  1115 RFLASELSEPFAQFLCDFFKPSLPTDAKMLKLLIETGIN-NAESQNSCESSLMSPELSEKSQNID 1178
                         .||..    :|.:.::|:||::.|.: ::|...:|   .:..:..|:..:|
 Frog   473 -------------SLCTL----IPKEQEVLQLLVKAGAHVDSEDDRTC---CIVRQALEREDSI- 516

  Fly  1179 FELADLLL---SSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHIELHKGKALIH 1240
                ..||   :|...|                     |.|..:.|...:.|.:::      :::
 Frog   517 ----RTLLDNGASVNQC---------------------DSNGRTLLANTAYSGNLD------VVN 550

  Fly  1241 ILANDGNHQLLERALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPCNDGTGRMK 1305
            :|.:.|:               ||||||.||||||.:|||.||::||..|:        |.|
 Frog   551 LLVSRGS---------------DLEIEDANGQTALTLAARQGHVKVVNCLI--------GCG--- 589

  Fly  1306 RVDVNHADRDGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLI 1370
             .::||.|.||||.||||:||||:|||..|:...| |:|.||.:.|||||||||.|||||:..|:
 Frog   590 -ANINHCDHDGWTALRSAAWGGHTEVVSALLYAGA-KVDCADADSRTALRAAAWGGHEDIVLNLL 652

  Fly  1371 ESGADVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLDGRSALCVAALC--GSSGYSK 1433
            :.||:||..|.:|||:||||:||||.:|||.||.:||.:||.|:|||:||.|||||  .|.|::.
 Frog   653 QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLGHGAEINHEDVDGRTALSVAALCVPASKGHAS 717

  Fly  1434 VISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACTAGHA 1498
            |:|.|::.||..|..|.|||:||||:::||:.:|.:||||..||.|..|..|||||.||.:.|||
 Frog   718 VVSLLIEQGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHA 782

  Fly  1499 TVVKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYAAFEGF 1563
            .||..|||||..:|.:||||||||||.:||||||.||.||||||||.|||:|||||||.|||||.
 Frog   783 AVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGH 847

  Fly  1564 HEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACLE 1628
            ..:|..|:|.||:.:|.||:|:..|.||||||...|||.||: :.|.||||.:||::|.|:|.||
 Frog   848 RLICEALIEQGARTNEIDNDGRIPLILAAQEGHYDCVQILLE-NKSAVDQKGYDGRSALRVAALE 911

  Fly  1629 GHMDTVEFLLKFCCDVNSKDADSRTTLYILALENKLEIVKYLLDMTNVDVNIPDSEGRTALHVAA 1693
            ||.|.||.||....|:|:||||.|.|||||||||:|.:.:|.|: ...:|...|::|||||||:.
 Frog   912 GHRDIVELLLSNGADLNAKDADGRPTLYILALENQLSMAEYFLE-NGANVEASDTDGRTALHVSC 975

  Fly  1694 WQGHADMVKTLIEAGADVNSMDLEARTPLHSCAWQGNHDVMNILLYYGALADHACKQGATALGIS 1758
            ||||.:||::||...||||:.|.|.|:.|.|.||||:..|:.:|:.:|.|.|:.|.||||||.|:
 Frog   976 WQGHLEMVQSLISYKADVNASDNEKRSSLQSAAWQGHVKVVQLLIEHGTLVDNTCNQGATALCIA 1040

  Fly  1759 AQEGHEKCVIALLQFGANPYKSDHCGRTPIKLAAKSSRTSILKIFESYTKNEASNPNEPKFHAHA 1823
            |||||...|..||:.||:|..:|..|||.:::|||:..:.|:|:.|.|..:..|..|....|...
 Frog  1041 AQEGHTDVVQFLLENGADPNHADQFGRTAMRVAAKNGHSEIIKLLEKYGASIPSGCNPSPVHTME 1105

  Fly  1824 SMLRSP--------------------DQPPALPLHQNLAPYPAHASASSVCSAATTATVHNGSHL 1868
            ..:.:|                    |..|::   :.|...||||.:|...|..:|...|..|
 Frog  1106 QKVLNPSSKVQSSTIKSNSSSSTGGGDVHPSM---RGLCNGPAHAFSSPSESPDSTVDRHKSS-- 1165

  Fly  1869 HVLNASSSTHSSNNFYQNTMQSDTSSLHKRKSVISSQSTGSSNDQAPLTFTQQLQRQSKLSSRNN 1933
                      .|||   :...|..|||....|..::|:....:... |:||:|:|:.|...||:
 Frog  1166 ----------LSNN---SLKSSKNSSLRTTSSTATAQTVPIDSFHC-LSFTEQIQQHSLPRSRS- 1215

  Fly  1934 LMVNSKHASSSGAAGHKSSGGGGGAQRHSQVLPDLSEHQLASNMTNEADMYDMECMSPLYATPPH 1998
                                      |.|.|.|..:.|.|..|                     :
 Frog  1216 --------------------------RQSIVSPSSTTHSLGQN---------------------Y 1233

  Fly  1999 SPSSELSSPGQLPGLNAFVDDE----RAGTSSGGGAK---------------------------- 2031
            ||:||.......|.|.:...::    .:.:.|...||
 Frog  1234 SPTSEFEWSQVKPSLKSTKTNKSGKGESSSKSNSVAKKTKQNCSSQPKVLEYEMTQFDKRVHPQD 1298

  Fly  2032 -LPDNHFARDTHMRI-----ILGNLKEN---QPSSSGKSKRSGVSSNPAMRLIRSRFDAASQLIR 2087
             ||..|...|:.::|     .:|..::.   |..:..:.||:|:.:||...|      ..:|:..
 Frog  1299 SLPLKHIPVDSKIQIPSVQQEVGRSQQQFLIQQQNLEQKKRNGIMTNPNYHL------QGNQVFL 1357

  Fly  2088 RTNNILSSSSNQG-----------SSSIGVKSG----------TFQWRKESQM 2119
            ...::..:..::|           .:.:|:|..          :|.::||:.:
 Frog  1358 GRVSVPRAVQSRGLQDVLEGYPSSETELGLKQSLKLQIEGSDPSFNYKKETPL 1410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	ANKYR	1236..1489	CDD:440430	129/254 (51%)
		ANK repeat	1270..1313	CDD:293786	18/42 (43%)
		ANK repeat	1315..1347	CDD:293786	19/31 (61%)
		ANK repeat	1349..1380	CDD:293786	19/30 (63%)
		ANK repeat	1382..1413	CDD:293786	20/30 (67%)
		ANK repeat	1415..1446	CDD:293786	17/32 (53%)
		ANKYR	1469..1788	CDD:440430	184/318 (58%)
		ANK repeat	1484..1515	CDD:293786	18/30 (60%)
		ANK repeat	1517..1548	CDD:293786	25/30 (83%)
		ANK repeat	1550..1581	CDD:293786	18/30 (60%)
		ANK repeat	1617..1648	CDD:293786	16/30 (53%)
		ANK repeat	1650..1682	CDD:293786	15/31 (48%)
		ANK repeat	1684..1715	CDD:293786	19/30 (63%)
		ANK repeat	1717..1742	CDD:293786	10/24 (42%)
		ANK repeat	1750..1775	CDD:293786	15/24 (63%)
ankrd50	XP_002942044.1	PHA03100	<483..>594	CDD:476869	40/172 (23%)
		ANK repeat	532..563	CDD:293786	9/51 (18%)
		ANKYR	546..839	CDD:440430	177/326 (54%)
		ANK repeat	565..596	CDD:293786	18/42 (43%)
		ANK repeat	598..629	CDD:293786	19/31 (61%)
		ANK repeat	631..662	CDD:293786	19/30 (63%)
		ANK repeat	664..695	CDD:293786	20/30 (67%)
		ANK repeat	697..733	CDD:293786	18/35 (51%)
		ANK repeat	735..766	CDD:293786	17/30 (57%)
		ANK repeat	768..799	CDD:293786	18/30 (60%)
		ANK repeat	801..832	CDD:293786	25/30 (83%)
		ANKYR	821..1090	CDD:440430	147/270 (54%)
		ANK repeat	835..865	CDD:293786	17/29 (59%)
		ANK repeat	867..898	CDD:293786	17/31 (55%)
		ANK repeat	900..931	CDD:293786	16/30 (53%)
		ANK repeat	933..964	CDD:293786	15/31 (48%)
		ANK repeat	966..997	CDD:293786	19/30 (63%)
		ANK repeat	999..1030	CDD:293786	13/30 (43%)
		ANK repeat	1032..1063	CDD:293786	18/30 (60%)
		ANK repeat	1065..1091	CDD:293786	10/25 (40%)