DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10011 and si:ch1073-398c20.3

DIOPT Version :9

Sequence 1:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster
Sequence 2:	XP_021331002.1	Gene:	si:ch1073-398c20.3 / 100331458	ZFINID:	ZDB-GENE-161017-19	Length:	418	Species:	Danio rerio

Alignment Length:	595	Identity:	102/595 - (17%)
Similarity:	174/595 - (29%)	Gaps:	256/595 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   612 IEAAIKDDKVEEP-QANNEDKKEDKPEADKELNDQL--KEELDKSSQEPKEEETKEEATADSSAE 673
            |:...:|.|:||. :..:||.        ::|.|.|  |||:      |:..:.|||...|....
Zfish     4 IKEESEDLKIEETFRVKHEDA--------EQLTDLLPWKEEI------PELNDVKEEKDLDEEGH 54

  Fly   674 PLIDFTESNVNGKQEEPQLKPPVPGEKPRISTNTLPPPLPKTKSCRTIIADGYYELLLSNPEILE 738
            .:     |.|...:...|...||                    ||.|....|  :.|.:...:.:
Zfish    55 LI-----SGVKTSENSAQQTGPV--------------------SCFTCKECG--KSLTTKRTLND 92

  Fly   739 CLSVDNIEKNPDECFKKAFLFPLLELTPPKTALLLLIDSIDENYINEGNLISTLKGGRGTVTNHK 803
            .:.:...|| |.:|                       ......||::    |||:  |..:|:..
Zfish    93 HMRIHTGEK-PCQC-----------------------KQCGNRYIDK----STLR--RHMITHTG 127

  Fly   804 SRNVAELLSNHIHLFPKWLFLVCT------TKKQTKQI-TKMFTGFKKITLDD-----LRKSH-- 854
            .|.                 ..|.      |:|...:: |::.||.|..|...     .|||:
Zfish   128 ERP-----------------FTCQQCGKGFTRKSNLEVHTRIHTGQKAFTCQQCGHGFTRKSNLE 175

  Fly   855 ----VVKDVQEYIINRLNSDFKDSIMLTKEIIESLHQLYIKSNGCILYLEKVLHGIKDNFFSFRE 915
                :....:.:|..:..:.|...::|  |:...:|
Zfish   176 VHTRIHTGEKPFICPQCGNCFSRKMLL--EVHMRIH----------------------------- 209

  Fly   916 IKLIPCTLNGLYLYICQ---KSFNKKQYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNYTIDCQE 977
                    .|...|.||   .||.:||.:.:.                     :||||
Zfish   210 --------TGKKPYACQHCGNSFTRKQSLDVH---------------------MRTHN------- 238

  Fly   978 FEKRLQLMRNI-LAYDSNAQRLKIFHNSFADWLVDVKFATKKFICDVNEGHVMISMYYLLVADTL 1041
             |:|..:.:.. :::        |:.||..:.:.: ....|.|.|.    |
Zfish   239 -EERPHICQECGVSF--------IYKNSLEEHMRN-HTGEKPFTCQ----H-------------- 275

  Fly  1042 CANTVRRFAYHLIRSGEYLTSRHVDLDLILMLLESRLNL-SDC----FYTNQMN----------- 1090
            |.|...|             .|::: |.:.:..|.|.:: .:|    .|.|.:.
Zfish   276 CGNGFTR-------------KRNLE-DHMRIHNEERPHICQECGVSFIYKNSLTEHMTTHTGEKP 326

  Fly  1091 -CCAQCEHDFKYDVNFLPKTRAMLERFLASELSEPFAQFLC--DFFKPSLPTDAKMLKLLIETGI 1152
             .|.||.:.|       .:.|.:.:..:.....:||....|  .|.|.|        .|.:...:
Zfish   327 FTCQQCGNGF-------TRKRNLKDHMITHTGEKPFTCEQCGKGFTKKS--------NLKVHMRV 376

  Fly  1153 NNAESQNSCE 1162
            :..|...:||
Zfish   377 HTEERPYTCE 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728	23/130 (18%)
		Ank_4	1237..1291	CDD:290365
		ANK	1266..1403	CDD:238125
		ANK repeat	1270..1313	CDD:293786
		Ank_2	1275..1380	CDD:289560
		ANK repeat	1315..1347	CDD:293786
		ANK repeat	1349..1380	CDD:293786
		Ank_2	1354..1449	CDD:289560
		ANK repeat	1382..1413	CDD:293786
		ANK	1410..1538	CDD:238125
		ANK repeat	1415..1446	CDD:293786
		Ank_5	1438..1489	CDD:290568
		ANK	1479..1604	CDD:238125
		ANK repeat	1484..1515	CDD:293786
		Ank_2	1489..1581	CDD:289560
		ANK repeat	1517..1548	CDD:293786
		ANK repeat	1550..1581	CDD:293786
		Ank_2	1555..1648	CDD:289560
		ANK	1578..1705	CDD:238125
		ANK repeat	1617..1648	CDD:293786
		Ank_2	1624..1715	CDD:289560
		ANK	1645..1771	CDD:238125
		ANK repeat	1650..1682	CDD:293786
		ANK repeat	1684..1715	CDD:293786
		Ank_2	1689..1781	CDD:289560
		ANK repeat	1717..1742	CDD:293786
		ANK repeat	1750..1775	CDD:293786
si:ch1073-398c20.3	XP_021331002.1	C2H2 Zn finger	77..97	CDD:275368	2/21 (10%)
		COG5048	90..411	CDD:227381	74/468 (16%)
		C2H2 Zn finger	105..125	CDD:275368	7/48 (15%)
		C2H2 Zn finger	133..153	CDD:275368	4/19 (21%)
		C2H2 Zn finger	161..181	CDD:275368	3/19 (16%)
		C2H2 Zn finger	189..209	CDD:275368	3/21 (14%)
		C2H2 Zn finger	217..237	CDD:275368	7/40 (18%)
		C2H2 Zn finger	245..265	CDD:275368	3/28 (11%)
		C2H2 Zn finger	273..293	CDD:275368	7/51 (14%)
		C2H2 Zn finger	301..321	CDD:275368	3/19 (16%)
		C2H2 Zn finger	329..349	CDD:275368	5/26 (19%)
		C2H2 Zn finger	357..377	CDD:275368	5/27 (19%)
		C2H2 Zn finger	385..405	CDD:275368	2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010