Protein Alignment CG10011 and ankrd50

DIOPT Version :10

• Sequence 1: NP_651624.2
• Gene: CG10011 / 43387
• FlyBaseID: FBgn0039590
• Length: 2119
• Species: Drosophila melanogaster
• Sequence 2: XP_073778504.1
• Gene: ankrd50 / 100136848
• ZFINID: ZDB-GENE-111027-23
• Length: 1406
• Species: Danio rerio
• Alignment Length: 1432
• Identity: 538/1432 - (37%)
• Similarity: 764/1432 - (53%)
• Gaps: 289/1432 - (20%)

  Fly   718 CRT-IIADGYYELLLSNPEILECLSVDNIEKNPDECFKKAFLFPLLELTPPKTALLLLIDSIDEN 781
            ||: ::.|  ||..|..|.|...|.....|:||.|.||:..|.|||....|..|:.||:||:||.
Zfish   122 CRSGLVPD--YEEKLREPAIQSALQPGECERNPAETFKRCVLLPLLSCKAPSQAVFLLLDSVDEG 184

  Fly   782 YINEGNLISTLKGGRGTVTNHKSRNVAELLSNHIHLFPKWLFLVCTTKKQTKQITKMFTGFKKIT 846
            .:         .|.|    :..|..:||||::|..|||.||.|:|:.::|.|.|||:||||:||:
Zfish   185 CV---------FGDR----DQTSAGIAELLADHQKLFPAWLLLICSARRQNKHITKLFTGFRKIS 236

  Fly   847 LDDLRKSHVVKDVQEYIINRLNSDFKDSIMLTKEIIESLHQLYIKSNGCILYLEKVLHGIKDNFF 911
            ||||||:::|||||:||::||:.:......||||..|.|:||:|||:||.||||:||.|:.:||.
Zfish   237 LDDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAEMLNQLHIKSSGCFLYLERVLDGVVENFI 301

  Fly   912 SFREIKLIPCTLNGLYLYICQKSFNKKQYMKIRPLLNVLLASSGYVDKLFLFNCLRTHNYTIDCQ 976
            ..|||:.||.|||||||::||:.|.:||:.|::|:|||:||:...:....|::.:.|.|.|:..:
Zfish   302 MLREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAACRPLTVRELYHAVWTKNMTLTME 366

  Fly   977 EFEKRLQLMRNILAYDSNAQRLKIFHNSFADWLVDVKFATKKFICDVNEGHVMISMYYLLVADTL 1041
            :|:|::.::..:|.....:.:: :||.|||:||:|||..|:|::|:..|||.|::|.|...|..|
Zfish   367 DFQKKMDILAKLLIDGLGSTKI-LFHYSFAEWLLDVKHCTQKYLCNAAEGHRMMAMSYTCRAKQL 430

  Fly  1042 CANTVRRFAYHLIRSGEYLTSRHVDLDLILMLLESRLNLSDCFYTNQMNCCAQCEHDFKYDVNFL 1106
            ....|:.||:|||:|                      ||.
Zfish   431 KPLEVQEFAHHLIKS----------------------NLQ------------------------- 448

  Fly  1107 PKTRAMLERFLASELSEPFAQFLC---------DFFKPSLPTDAKMLKLLIETG--INNAESQNS 1160
                           .|||...|.         |....|:|.:.::|:||::.|  ::|.:...|
Zfish   449 ---------------IEPFNLALWMVWNGTPAKDSLSTSIPKEQEVLQLLVKAGAHVSNEDDHAS 498

  Fly  1161 CESSLMSPELSEKSQNIDFELADLLLSSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLS 1225
            |        :.:::...:..:..||                            |..||  ::| :
Zfish   499 C--------IVQQALEREDSIRTLL----------------------------DNGAS--VNQ-T 524

  Fly  1226 DSHHIELHKGKALIHILANDGN----HQLLERALNACKSPIDLEIEDYNGQTALNIAARNGHLEV 1286
            ||:      |:.|:...|..||    :.|:.|..|       :|:.|.:|||||.:|||.||.:|
Zfish   525 DSN------GRTLLANAAYSGNLEVVNLLISRRAN-------MELVDSHGQTALTLAARQGHTKV 576

  Fly  1287 VKLLLSFSQPCNDGTGRMKRVDVNHADRDGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGR 1351
            |..|:.    |:        .::||.|.||||.||||:||||||||..|:...| |:|.||.:.|
Zfish   577 VNCLIG----CD--------ANINHTDHDGWTALRSAAWGGHSEVVSALLYAGA-KVDCADADSR 628

  Fly  1352 TALRAAAWSGHEDILKLLIESGADVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLDG 1416
            ||||||||.|||||:..|::.||:||..|.:|||:||||:||||.:|||.||::||.|||.|:||
Zfish   629 TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDG 693

  Fly  1417 RSALCVAALC--GSSGYSKVISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPD 1479
            |:||.|||||  .|.|:..|:|.|:|.||..|..|.|.|:||||:::||:.:|.:||||..||.|
Zfish   694 RTALSVAALCVPASKGHGAVVSLLIDRGAEVDHCDKDCMTPLLVAAYEGHVDVVDLLLEGGADVD 758

  Fly  1480 LADFMGRTPLWAACTAGHATVVKLLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDE 1544
            ..|..|||||.||.:.|||:||..|||||..:|.:||||||||||.:||||||.||.||||||||
Zfish   759 HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE 823

  Fly  1545 THRDNAGWTPLHYAAFEGFHEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSS 1609
            .|||:|||||||.|:|||..:||..|:|.|::..|.||:|:..|.|:||||...||..||: :.|
Zfish   824 NHRDDAGWTPLHMASFEGHRQVCDALIEQGSRSTEVDNDGRIPLVLSAQEGHYDCVHILLE-NKS 887

  Fly  1610 FVDQKAHDGKTAFRLACLEGHMDTVEFLLKFCCDVNSKDADSRTTLYILALENKLEIVKYLLDMT 1674
            .:||:.:||:.|.|:|.||||.|.||.||....|::.||||.|.|||||||||:|.:.:|.|: .
Zfish   888 CIDQRGYDGRNALRVAALEGHRDIVELLLSHEADIDFKDADGRPTLYILALENQLAMAEYFLE-N 951

  Fly  1675 NVDVNIPDSEGRTALHVAAWQGHADMVKTLIEAGADVNSMDLEARTPLHSCAWQGNHDVMNILLY 1739
            ..:|...|.||||||||:.||||.:||:.||...|||||.|.|.|:.|.|.||||:..::..|:.
Zfish   952 GANVEASDMEGRTALHVSCWQGHVEMVRLLINYHADVNSCDNEKRSALQSAAWQGHIKIVQTLID 1016

  Fly  1740 YGALADHACKQGATALGISAQEGHEKCVIALLQFGANPYKSDHCGRTPIKLAAKSSRTSILKIFE 1804
            .|.:.||.|.||||||||:|||||.:.|..||:..|:|..:|..|||.:::|||...|:|:|:.|
Zfish  1017 NGTVVDHTCNQGATALGIAAQEGHIEVVQILLEHSADPNHADQFGRTAMRVAAKGGHTAIIKLLE 1081

  Fly  1805 SY--TKNEASNPNEPKFHAHASMLRSPDQPPALPLHQNLAPYPAHASASSVCSAATTATVHNGSH 1867
            .|  |.....||:                    |:|......|.     ||.....:.|:.:.|
Zfish  1082 KYGATSLNGCNPS--------------------PVHTMEQQTPV-----SVAGKVQSLTIKSSS- 1120

  Fly  1868 LHVLNASSST-----HSSN--------NFYQNTMQSDTSSLHKRKSVISSQSTGSSNDQAPLTFT 1919
                  |.||     ||:.        :.:.:..:|..|::.::||.:|:.|..||.:.:
Zfish  1121 ------SGSTGAGDVHSAGRGQSNGPVHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSS----- 1174

  Fly  1920 QQLQRQSKLSSRNNLMVNSKHASSSGAAGHKSSGGGGGAQRHSQVLPDLSEHQLASNMTNEADMY 1984
              |:..|..::...:.::|.||.|                    .:..:.:|.|..:.:.::
Zfish  1175 --LRTTSSTATAQTVPIDSVHALS--------------------FIEQIQQHSLPRSRSRQS--- 1214

  Fly  1985 DMECMSP-----LYATPPHSPSSELSSPGQLPGL-------------NAFVDDERAGTSSGGGA- 2030
               .:||     ...|.|.||:||.......|||             |.....|:....:|..:
Zfish  1215 ---IVSPSSTTRSIGTQPGSPTSEFDWSQVKPGLKSTKATKNGQNCSNKGTSGEKKKNKNGSYSQ 1276

  Fly  2031 ----------------KLPDNHFARDTHMRIILG--NLKEN---------QPSSSGKSKRSGVSS 2068
                            |...|...:|...:|::|  |..::         |..|..:.||:|:.:
Zfish  1277 GQVLEYELTQFDKRFNKPVSNIAVKDPQCKIVVGRSNALDSVQSQEQFYIQSQSCAEKKRNGIMT 1341

  Fly  2069 NP 2070
            ||
Zfish  1342 NP 1343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10011	NP_651624.2	ANKYR	1236..1489	CDD:440430	130/258 (50%)
		ANK repeat	1270..1313	CDD:293786	16/42 (38%)
		ANK repeat	1315..1347	CDD:293786	20/31 (65%)
		ANK repeat	1349..1380	CDD:293786	19/30 (63%)
		ANK repeat	1382..1413	CDD:293786	21/30 (70%)
		ANK repeat	1415..1446	CDD:293786	18/32 (56%)
		ANKYR	1469..1788	CDD:440430	179/318 (56%)
		ANK repeat	1484..1515	CDD:293786	18/30 (60%)
		ANK repeat	1517..1548	CDD:293786	25/30 (83%)
		ANK repeat	1550..1581	CDD:293786	17/30 (57%)
		ANK repeat	1617..1648	CDD:293786	15/30 (50%)
		ANK repeat	1650..1682	CDD:293786	15/31 (48%)
		ANK repeat	1684..1715	CDD:293786	21/30 (70%)
		ANK repeat	1717..1742	CDD:293786	9/24 (38%)
		ANK repeat	1750..1775	CDD:293786	16/24 (67%)
ankrd50	XP_073778504.1	None