DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9986 and C12orf4

DIOPT Version :9

Sequence 1:	NP_651623.1	Gene:	CG9986 / 43386	FlyBaseID:	FBgn0039589	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001291740.1	Gene:	C12orf4 / 57102	HGNCID:	1184	Length:	552	Species:	Homo sapiens

Alignment Length:	556	Identity:	199/556 - (35%)
Similarity:	304/556 - (54%)	Gaps:	42/556 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RTLPFVYKYKNHKGQDC-ESRLDITFPFDQENLEECITQLMAPNQMDPMMRYLDENIKLERELQK 70
            |...||||:|  .|..| |.|:.:.||. |||......:||.   :..:..::::::|  ..|.:
Human    11 REREFVYKFK--VGSQCLELRVPLKFPV-QENASHLHGRLML---LHSLPCFIEKDLK--EALTQ 67

  Fly    71 FVDTEQQNFLDDQAEKLLKQAANEEMDIEAIVRDTERLYKEELLQFADRVGPSDADIFAQSFHRL 135
            |::.|..:..|..||..|....:.|:|:..:.....:.|.|..|:.|....||..:.||..:|.|
Human    68 FIEEESLSDYDRDAEASLAAVKSGEVDLHQLASTWAKAYAETTLEHARPEEPSWDEDFADVYHDL 132

  Fly   136 VHSSSLEDILKRERAYAKVVSDMTDLMDSEVETLNNSQQQEMDSQINQLDITTTSEDINNLLAQQ 200
            :||.:.|.:|..|..|...:|::....|.|::.|...|..||:..:.:|..:.|.:|:|:|.||.
Human   133 IHSPASETLLNLEHNYFVSISELIGERDVELKKLRERQGIEMEKVMQELGKSLTDQDVNSLAAQH 197

  Fly   201 YTTQNYVRKRYESELEAMMGHQKNEYRNWI-----------TSQVSQMFQVSPVATPLGNRSSM- 253
            :.:|..:..::.:||:.....||.||:.|:           .|.:|:..:|.|...    |.|:
Human   198 FESQQDLENKWSNELKQSTAIQKQEYQEWVIKLHQDLKNPNNSSLSEEIKVQPSQF----RESVE 258

  Fly   254 ----FVSQQPSMEESFTIHLGSQLKHMHNIRILSANVTELCSPLHAEES---LNGLNMALGLYSS 311
                ...:|..:|||||||||:|||.|||:|:|.|::.:.|.......|   |:.|..||.|||:
Human   259 AIGRIYEEQRKLEESFTIHLGAQLKTMHNLRLLRADMLDFCKHKRNHRSGVKLHRLQTALSLYST 323

  Fly   312 SLCGVVVLTPS-IQAQA--NKNIIKNANKSTEFHFEQIDVQMEKIEKQIKNLTTEDSSGSSTSNS 373
            ||||:|:|..: |.:.:  .::......:.|:|||.:|:.|:|.:::.:....|:..|....|..
Human   324 SLCGLVLLVDNRINSYSGIKRDFATVCQECTDFHFPRIEEQLEVVQQVVLYARTQRRSKLKESLD 388

  Fly   374 SAEGSGTPSPTKKSVPR----LKTGDFFITKHSNLSQTHVIFHLISDEPINSPSEINSRHPVILG 434
            |...:|......|:..|    :..|:|:||:|||||:.||.|||..|:.:.| ..|.:|.|.|:|
Human   389 SGNQNGGNDDKTKNAERNYLNVLPGEFYITRHSNLSEIHVAFHLCVDDHVKS-GNITARDPAIMG 452

  Fly   435 LRNILKTASRHDITTLTIPALLRHEMSEDMTVQWCIRRAELVFKCAKGFMIESASWGGAELSTLQ 499
            ||||||....|||||::||.||.|:|||:||:.||:|||||||||.||||:|.|||.|....|:|
Human   453 LRNILKVCCTHDITTISIPLLLVHDMSEEMTIPWCLRRAELVFKCVKGFMMEMASWDGGISRTVQ 517

  Fly   500 LLLPDDISESLFTTLAGMVPSVFHVANPKILVDTSK 535
            .|:|..|||.:|..|:.|:|.:|.|::...|  |||
Human   518 FLVPQSISEEMFYQLSNMLPQIFRVSSTLTL--TSK 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9986	NP_651623.1	DUF2362	44..528	CDD:287163	180/509 (35%)
C12orf4	NP_001291740.1	DUF2362	41..546	CDD:313393	180/514 (35%)
C12orf4	NP_001291740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..403		4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159956
Domainoid	1	1.000	305	1.000	Domainoid score	I1373
eggNOG	1	0.900	-	-		E1_KOG4506
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10685
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2555
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52561
OrthoDB	1	1.010	-	-		D285902at33208
OrthoFinder	1	1.000	-	-		FOG0007202
OrthoInspector	1	1.000	-	-		oto91534
orthoMCL	1	0.900	-	-		OOG6_106014
Panther	1	1.100	-	-	LDO	PTHR16525
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3086
SonicParanoid	1	1.000	-	-		X5311
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800