DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9986 and JUN

DIOPT Version :9

Sequence 1:	NP_651623.1	Gene:	CG9986 / 43386	FlyBaseID:	FBgn0039589	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_002219.1	Gene:	JUN / 3725	HGNCID:	6204	Length:	331	Species:	Homo sapiens

Alignment Length:	231	Identity:	46/231 - (19%)
Similarity:	82/231 - (35%)	Gaps:	83/231 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 NIRILSANVTELCSPLHAEESLNGLNMALGLYSSSLCGVVVLTPSIQAQANKNIIKNANKSTEFH 342
            |.:||..::|              ||:|..:.|        |.|.::|       ||::..|
Human    30 NPKILKQSMT--------------LNLADPVGS--------LKPHLRA-------KNSDLLT--- 62

  Fly   343 FEQIDVQMEKI-EKQIKNLTTEDSSGSSTSNSSAEGSGTPSPTKKSVPRLKT------GDFFITK 400
              ..||.:.|: ..:::.|..:.|:|..|:        ||:||:...|:..|      .:.|:..
Human    63 --SPDVGLLKLASPELERLIIQSSNGHITT--------TPTPTQFLCPKNVTDEQEGFAEGFVRA 117

  Fly   401 HSNLSQTHVIFHLIS-DEPINS--------------------PSEINSRHPVILGLRNI----LK 440
            .:.|...:.:..:.| .:|:|.                    .:.::|..||...|.|.    |.
Human   118 LAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALS 182

  Fly   441 T---ASRHDITTLTIPALLR------HEMSEDMTVQ 467
            :   |..:....|..||..:      |.:.:.|.||
Human   183 SGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQ 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9986	NP_651623.1	DUF2362	44..528	CDD:287163	46/231 (20%)
JUN	NP_002219.1	Jun	5..241	CDD:309180	46/231 (20%)
		Interaction with PAGE4. /evidence=ECO:0000269\|PubMed:26242913	150..223		14/69 (20%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	252..279
		bZIP_Jun	254..314	CDD:269844
		coiled coil	255..306	CDD:269844
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	280..308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S81
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950