DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9986 and RGD1311164

DIOPT Version :9

Sequence 1:	NP_651623.1	Gene:	CG9986 / 43386	FlyBaseID:	FBgn0039589	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001100093.1	Gene:	RGD1311164 / 297607	RGDID:	1311164	Length:	552	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	193/547 - (35%)
Similarity:	299/547 - (54%)	Gaps:	32/547 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FVYKYKNHKGQDCESRLDITFPFDQENLEECITQLMAPNQMDPMMRYLDENIKLERELQKFVDTE 75
            ||||:: ...:..|.|:.:.||.| ||......:||..:.:...:    || .|:..|.:|::.|
  Rat    15 FVYKFQ-IGSERLELRVPLRFPVD-ENASHLHGRLMLLHSLPCFI----EN-DLKEALARFIEEE 72

  Fly    76 QQNFLDDQAEKLLKQAANEEMDIEAIVRDTERLYKEELLQFADRVGPSDADIFAQSFHRLVHSSS 140
            .....|..||..|:...:.|:|:..:.....:.|.|..|:.|....|:..:.||..:|.|:||.:
  Rat    73 SLRDHDSDAEACLEAVKSGEVDLHQLASTWAKAYAETTLEHARPEEPNWDEDFADVYHDLIHSPA 137

  Fly   141 LEDILKRERAYAKVVSDMTDLMDSEVETLNNSQQQEMDSQINQLDITTTSEDINNLLAQQYTTQN 205
            .|.:|..|..|...:|::....|.|::.|...|..||:..:.:|..:.|.:|:|:|.||.:.:|.
  Rat   138 SETLLNLEHNYFVSISELIGERDVELKKLRERQGIEMEKVMQELGKSLTDQDVNSLAAQHFESQQ 202

  Fly   206 YVRKRYESELEAMMGHQKNEYRNWI-----------TSQVSQMFQVSPVA-TPLGNRSSMFVSQQ 258
            .:..::.:||:.....||.||:.|:           .|.:|:..:|.|.. ....:.:.....:|
  Rat   203 DLENKWSNELKQSTAIQKQEYQEWVIKLHQDLKNPNNSSLSEEIKVQPSQFRESADAAGRIYEEQ 267

  Fly   259 PSMEESFTIHLGSQLKHMHNIRILSANVTELCSPLHAEES---LNGLNMALGLYSSSLCGVVVLT 320
            ..:|||||||||:|||.|||:|:|.|::.:.|.....:.|   |:.|..||.|||:||||:|:|.
  Rat   268 RKLEESFTIHLGAQLKTMHNLRLLRADMLDFCKHKRTQGSGVKLHRLQTALSLYSTSLCGLVLLV 332

  Fly   321 PS-IQAQA--NKNIIKNANKSTEFHFEQIDVQMEKIEKQIKNLTTEDSSGSSTSNSSAEGSGTPS 382
            .: |.:.:  .::......:.|:|||.:|:.|:|.:::......|:..|....:..|...:|...
  Rat   333 DNRINSYSGIKRDFATVCQECTDFHFPRIEEQLEVVQQVALYARTQRRSKCKEARDSGNQNGGSD 397

  Fly   383 PTKKSVPR----LKTGDFFITKHSNLSQTHVIFHLISDEPINSPSEINSRHPVILGLRNILKTAS 443
            ...|:..|    :..|:|:||:|||||:.||.|||..|:.:.| ..|.:|.|.|:|||||||...
  Rat   398 EKSKNAERNYLNILPGEFYITRHSNLSEIHVAFHLCVDDNVKS-GNITARDPAIMGLRNILKVCC 461

  Fly   444 RHDITTLTIPALLRHEMSEDMTVQWCIRRAELVFKCAKGFMIESASWGGAELSTLQLLLPDDISE 508
            .|||||::||.||.|:|||:||:.||:|||||||||.||||:|.|||.|....|:|.|:|..|||
  Rat   462 THDITTISIPLLLVHDMSEEMTIPWCLRRAELVFKCVKGFMMEMASWDGGISRTVQFLVPQSISE 526

  Fly   509 SLFTTLAGMVPSVFHVANPKILVDTSK 535
            .:|..|:.|:|.:|.|::...|  |||
  Rat   527 EMFYQLSNMLPQIFRVSSTLTL--TSK 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9986	NP_651623.1	DUF2362	44..528	CDD:287163	178/505 (35%)
RGD1311164	NP_001100093.1	DUF2362	41..546	CDD:401963	178/510 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354025
Domainoid	1	1.000	308	1.000	Domainoid score	I1299
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10685
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2493
OMA	1	1.010	-	-		QHG52561
OrthoDB	1	1.010	-	-		D285902at33208
OrthoFinder	1	1.000	-	-		FOG0007202
OrthoInspector	1	1.000	-	-		oto98607
orthoMCL	1	0.900	-	-		OOG6_106014
Panther	1	1.100	-	-	LDO	PTHR16525
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5311
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910