DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9986 and D6Wsu163e

DIOPT Version :9

Sequence 1:	NP_651623.1	Gene:	CG9986 / 43386	FlyBaseID:	FBgn0039589	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_613060.1	Gene:	D6Wsu163e / 28040	MGIID:	107893	Length:	552	Species:	Mus musculus

Alignment Length:	547	Identity:	190/547 - (34%)
Similarity:	299/547 - (54%)	Gaps:	32/547 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FVYKYKNHKGQDCESRLDITFPFDQENLEECITQLMAPNQMDPMMRYLDENIKLERELQKFVDTE 75
            ||||::..: :..|.|:.:.||. :||......:||.   :..:..:::.::|  ..|.:|::.|
Mouse    15 FVYKFQVGR-ERLELRVPLRFPV-EENASHLHGRLML---LHSLPCFIESDLK--DALSRFIEEE 72

  Fly    76 QQNFLDDQAEKLLKQAANEEMDIEAIVRDTERLYKEELLQFADRVGPSDADIFAQSFHRLVHSSS 140
            .....|..||..|:...:.|:|:..:.....:.|.|..|:.|....|...:.||..:|.|:||.:
Mouse    73 SLRDHDSDAEACLEAVKSGEVDLHQLASAWAKAYAETTLEHARPEEPDWDEDFADVYHDLIHSPA 137

  Fly   141 LEDILKRERAYAKVVSDMTDLMDSEVETLNNSQQQEMDSQINQLDITTTSEDINNLLAQQYTTQN 205
            .|.:|..|..|...:|::....|.|::.|...|..||:..:.:|..:.|.:|:|:|.||.:.:|.
Mouse   138 SETLLNLEHNYFVSISELIGERDVELKKLRERQGIEMEKVMQELGKSLTDQDVNSLAAQHFESQQ 202

  Fly   206 YVRKRYESELEAMMGHQKNEYRNWI-----------TSQVSQMFQVSPVA-TPLGNRSSMFVSQQ 258
            .:..::.:||:.....||.||:.|:           .|.:|:..:|.|.. ....:.:.....:|
Mouse   203 DLENKWSNELKQSTAIQKQEYQEWVIKLHQDLKNPNNSSLSEEIKVQPSQFRESADAAGRIYEEQ 267

  Fly   259 PSMEESFTIHLGSQLKHMHNIRILSANVTELCSPLHAEES---LNGLNMALGLYSSSLCGVVVLT 320
            ..:|||||||||:|||.|||:|:|.|::.:.|.......|   |:.|..||.|||:||||:|:|.
Mouse   268 RKLEESFTIHLGAQLKTMHNLRLLRADMLDFCKHKRTHGSGVKLHRLQTALSLYSTSLCGLVLLV 332

  Fly   321 PS-IQAQA--NKNIIKNANKSTEFHFEQIDVQMEKIEKQIKNLTTEDSSGSSTSNSSAEGSGTPS 382
            .: |.:.:  .::......:.|:|||.:|:.|:|.:::......|:..|....:..|...:|...
Mouse   333 DNRINSYSGIKRDFATVCQECTDFHFPRIEEQLEVVQQVALYARTQRKSKCKEARDSGNQNGGSD 397

  Fly   383 PTKKSVPR----LKTGDFFITKHSNLSQTHVIFHLISDEPINSPSEINSRHPVILGLRNILKTAS 443
            ...|:..|    :..|:|:||:|||||:.||.|||..|:.:.| ..|.:|.|.|:|||||||...
Mouse   398 DKSKNAERNYLNILPGEFYITRHSNLSEIHVAFHLCVDDNVKS-GNITARDPAIMGLRNILKVCC 461

  Fly   444 RHDITTLTIPALLRHEMSEDMTVQWCIRRAELVFKCAKGFMIESASWGGAELSTLQLLLPDDISE 508
            .|||||::||.||.|:|||:||:.||:|||||||||.||||:|.|||.|....|:|.|:|..|||
Mouse   462 THDITTISIPLLLVHDMSEEMTIPWCLRRAELVFKCVKGFMMEMASWDGGISRTVQFLVPQSISE 526

  Fly   509 SLFTTLAGMVPSVFHVANPKILVDTSK 535
            .:|..|:.|:|.:|.|::...|  |||
Mouse   527 EMFYQLSNMLPQIFRVSSTLTL--TSK 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9986	NP_651623.1	DUF2362	44..528	CDD:287163	176/505 (35%)
D6Wsu163e	NP_613060.1	DUF2362	41..546	CDD:370836	176/510 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850327
Domainoid	1	1.000	305	1.000	Domainoid score	I1356
eggNOG	1	0.900	-	-		E1_KOG4506
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10685
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2565
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52561
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007202
OrthoInspector	1	1.000	-	-		oto95115
orthoMCL	1	0.900	-	-		OOG6_106014
Panther	1	1.100	-	-	LDO	PTHR16525
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3086
SonicParanoid	1	1.000	-	-		X5311
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790