DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb98DE and HRB1

DIOPT Version :9

Sequence 1:	NP_524543.1	Gene:	Hrb98DE / 43385	FlyBaseID:	FBgn0001215	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_014394.2	Gene:	HRB1 / 855728	SGDID:	S000004949	Length:	454	Species:	Saccharomyces cerevisiae

Alignment Length:	231	Identity:	53/231 - (22%)
Similarity:	98/231 - (42%)	Gaps:	36/231 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NSNQNQNGNSNGHDDDFP-----QDSITEPE----HMRKLFIGGLDYRTTDENLKAHFEKWGNIV 58
            :|.:...|:|....|..|     .||..|.:    :...:|:|.|.|.:|.|:|...|.:.|.:|
Yeast   124 DSRRGGFGSSGARGDYGPLLARELDSTYEEKVNRNYSNSIFVGNLTYDSTPEDLTEFFSQIGKVV 188

  Fly    59 --DVVVMKDPRTKRSRGFGFITYSHSSMIDEAQKSRPHKIDGRVVEPKRAVPRQDIDSPNAGATV 121
              |::..:.    ..||.|.:.:::|..:|.|.:    :.||.....::...|||...|:.....
Yeast   189 RADIITSRG----HHRGMGTVEFTNSDDVDRAIR----QYDGAFFMDRKIFVRQDNPPPSNNIKE 245

  Fly   122 KK-LFVGALKDD---HDE-----------QSIRDYFQHFGNIVDINIVIDKETGKKRGFAFVEFD 171
            :| |..|.|:.:   |:.           |:::|.|:..||:...::.:|.: |...|...|.|.
Yeast   246 RKALDRGELRHNRKTHEVIVKNLPASVNWQALKDIFKECGNVAHADVELDGD-GVSTGSGTVSFY 309

  Fly   172 DYDPVDKVVLQ-KQHQLNGKMVDVKKALPKQNDQQG 206
            |...:.:.:.: ..:.:.|.::|||......|...|
Yeast   310 DIKDLHRAIEKYNGYSIEGNVLDVKSKESVHNHSDG 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb98DE	NP_524543.1	RRM1_hnRNPA_like	32..109	CDD:241022	19/78 (24%)
Hrb98DE	NP_524543.1	RRM_SF	123..195	CDD:302621	18/87 (21%)
HRB1	NP_014394.2	PRK12678	<29..>85	CDD:237171
		RRM1_HRB1_GBP2	160..236	CDD:410184	21/83 (25%)
		RRM2_HRB1_GBP2	262..334	CDD:410185	13/72 (18%)
		RRM3_HRB1_GBP2	374..452	CDD:410186
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910