DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb98DE and HNRNPA2B1

DIOPT Version :9

Sequence 1:	NP_524543.1	Gene:	Hrb98DE / 43385	FlyBaseID:	FBgn0001215	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_112533.1	Gene:	HNRNPA2B1 / 3181	HGNCID:	5033	Length:	353	Species:	Homo sapiens

Alignment Length:	348	Identity:	173/348 - (49%)
Similarity:	222/348 - (63%)	Gaps:	30/348 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EPEHMRKLFIGGLDYRTTDENLKAHFEKWGNIVDVVVMKDPRTKRSRGFGFITYSHSSMIDEAQK 90
            |.|..||||||||.:.||:|:|:.::|:||.:.|.|||:||.:||||||||:|:|..:.:|.|..
Human    16 EKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMA 80

  Fly    91 SRPHKIDGRVVEPKRAVPRQDIDSPNAGATVKKLFVGALKDDHDEQSIRDYFQHFGNIVDINIVI 155
            :|||.||||||||||||.|::...|.|..||||||||.:|:|.:|..:||||:.:|.|..|.|:.
Human    81 ARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIIT 145

  Fly   156 DKETGKKRGFAFVEFDDYDPVDKVVLQKQHQLNGKMVDVKKALPKQNDQ--QGGGGGRGGPGGRA 218
            |:::||||||.||.|||:|||||:||||.|.:||...:|:|||.:|..|  |....||||..| .
Human   146 DRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFG-F 209

  Fly   219 GGNRGNMGGGNYGNQNGGGNWNNGGNNWGNNRGGNDNWGNNSFGGGGGGGG-----GYGGGNNSW 278
            |.:||  ||||:| ...|.|:..|.:.:|:.||..|  |.|.:|||.|||.     |||||...:
Human   210 GDSRG--GGGNFG-PGPGSNFRGGSDGYGSGRGFGD--GYNGYGGGPGGGNFGGSPGYGGGRGGY 269

  Fly   279 GNNNPWDNGNGGGNFGGGGNNWNNGG------NDFGGYQQ---NYGGGPQRGGGNFNNNRMQ--P 332
            |...| ..||.||.:|||.:|:..|.      ||||.|.|   ||  ||.: .|||..:|..  |
Human   270 GGGGP-GYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNY--GPMK-SGNFGGSRNMGGP 330

  Fly   333 YQGGGGFKAGG-GNQGNYGGNNQ 354
            | |||.:..|| |..|.|||.::
Human   331 Y-GGGNYGPGGSGGSGGYGGRSR 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb98DE	NP_524543.1	RRM1_hnRNPA_like	32..109	CDD:241022	47/76 (62%)
Hrb98DE	NP_524543.1	RRM_SF	123..195	CDD:302621	40/71 (56%)
HNRNPA2B1	NP_112533.1	Nuclear localization signal. /evidence=ECO:0000255	9..15
		RRM1_hnRNPA2B1	19..99	CDD:410155	48/79 (61%)
		RRM2_hnRNPA2B1	112..191	CDD:409995	45/78 (58%)
		Disordered. /evidence=ECO:0000269\|PubMed:26544936	193..353		72/171 (42%)
		HnRNPA1	302..326	CDD:402981	12/26 (46%)
		Nuclear targeting sequence. /evidence=ECO:0000250	308..347		18/42 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6828
eggNOG	1	0.900	-	-		E33208_3BA81
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2209
Isobase	1	0.950	-	0	Normalized mean entropy	S742
OMA	1	1.010	-	-		QHG46466
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	1	1.000	-	-		FOG0000779
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103644
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2767
SonicParanoid	1	1.000	-	-		X431
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.720