DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hrb98DE and HNRNPA1

DIOPT Version :9

Sequence 1:	NP_524543.1	Gene:	Hrb98DE / 43385	FlyBaseID:	FBgn0001215	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_112420.1	Gene:	HNRNPA1 / 3178	HGNCID:	5031	Length:	372	Species:	Homo sapiens

Alignment Length:	372	Identity:	179/372 - (48%)
Similarity:	235/372 - (63%)	Gaps:	32/372 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSITEPEHMRKLFIGGLDYRTTDENLKAHFEKWGNIVDVVVMKDPRTKRSRGFGFITYSHSSMID 86
            :|..|||.:||||||||.:.||||:|::|||:||.:.|.|||:||.|||||||||:||:....:|
Human     5 ESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVD 69

  Fly    87 EAQKSRPHKIDGRVVEPKRAVPRQDIDSPNAGATVKKLFVGALKDDHDEQSIRDYFQHFGNIVDI 151
            .|..:||||:|||||||||||.|:|...|.|..||||:|||.:|:|.:|..:||||:.:|.|..|
Human    70 AAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVI 134

  Fly   152 NIVIDKETGKKRGFAFVEFDDYDPVDKVVLQKQHQLNGKMVDVKKALPK---------QNDQQGG 207
            .|:.|:.:|||||||||.|||:|.|||:|:||.|.:||...:|:|||.|         |..:.|.
Human   135 EIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGS 199

  Fly   208 GGGRGGPGGRAGGNRGNMG-GGNYGNQNGGGNWNNGGNNWGNNRGGNDNWGNN-SFGGGG----G 266
            |...||.||..||| .|.| |||:..:.|.|. :.||..:|.:..|.:.:||: .:||||    |
Human   200 GNFGGGRGGGFGGN-DNFGRGGNFSGRGGFGG-SRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSG 262

  Fly   267 GGGGYGGGNNSWGNN----------NPWDNGNGGGNFGGGGNNWNNGG--NDFGGY-QQNYGGGP 318
            |..|||.|...:||.          :.::||.|||..||.|:|:..||  ||||.| .|:...||
Human   263 GSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGP 327

  Fly   319 QRGGGNFNNNRMQPYQGGGGFKAGGGNQGNYGGNNQGFNNGGNNRRY 365
            .: ||||......||.|||.:.|...|||.|||::.. ::.|:.||:
Human   328 MK-GGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSS-SSYGSGRRF 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb98DE	NP_524543.1	RRM1_hnRNPA_like	32..109	CDD:241022	51/76 (67%)
Hrb98DE	NP_524543.1	RRM_SF	123..195	CDD:302621	38/71 (54%)
HNRNPA1	NP_112420.1	Globular A domain	4..94		57/88 (65%)
		RRM1_hnRNPA1	12..92	CDD:410154	52/79 (66%)
		Globular B domain	95..185		48/89 (54%)
		RRM2_hnRNPA3	105..184	CDD:409996	43/78 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..216		11/34 (32%)
		RNA-binding RGG-box	218..240		8/22 (36%)
		HnRNPA1	307..344	CDD:402981	16/37 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..372		22/56 (39%)
		Nuclear targeting sequence (M9)	320..357		16/37 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6828
eggNOG	1	0.900	-	-		E33208_3BA81
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2209
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46466
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	1	1.000	-	-		FOG0000779
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103644
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.780