DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb98DE and HNRNPA1L2

DIOPT Version :9

Sequence 1:	NP_524543.1	Gene:	Hrb98DE / 43385	FlyBaseID:	FBgn0001215	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_001011724.1	Gene:	HNRNPA1L2 / 144983	HGNCID:	27067	Length:	320	Species:	Homo sapiens

Alignment Length:	344	Identity:	170/344 - (49%)
Similarity:	216/344 - (62%)	Gaps:	36/344 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EPEHMRKLFIGGLDYRTTDENLKAHFEKWGNIVDVVVMKDPRTKRSRGFGFITYSHSSMIDEAQK 90
            |||.:||||||||.:.||||:|::|||:||.:.|.|||:||.|||||||||:||:....:|.|..
Human     9 EPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMN 73

  Fly    91 SRPHKIDGRVVEPKRAVPRQDIDSPNAGATVKKLFVGALKDDHDEQSIRDYFQHFGNIVDINIVI 155
            :.|||:|||||||||||.|:|...|.|..||||:|||.:|:|.:|..:||||:.:|.|..|.|:.
Human    74 TTPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMT 138

  Fly   156 DKETGKKRGFAFVEFDDYDPVDKVVLQKQHQLNGKMVDVKKALPKQNDQQGGGGGRGGPGGRAGG 220
            |:.:|||||||||.|||:|.|||:|:||.|.:.|...:|:||||||.           ....:..
Human   139 DRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVKGHNCEVRKALPKQE-----------MASASSS 192

  Fly   221 NRGNMGGGNYGNQNGGGNWNNGGN-NWGNNRGGNDNWGNNSFGG--GGGGGGGYGGGNNSWGNNN 282
            .||..|.||:|...|.|   .||| |:|  ||||.: |...|||  ||||.||.|.|.|.:||:
Human   193 QRGRRGSGNFGGGRGDG---FGGNDNFG--RGGNFS-GRGGFGGSCGGGGYGGSGDGYNGFGND- 250

  Fly   283 PWDNGNGGGNFGGGGNNWNNGGNDFGGY-QQNYGGGPQRGGGNFNNNRMQPYQGGGGFKAGGGNQ 346
                   |.||||||:.     ||||.| .|:...||.: ||||......||.|||.:.|...||
Human   251 -------GSNFGGGGSY-----NDFGNYNNQSSNFGPMK-GGNFGGRSSGPYGGGGQYFAKPQNQ 302

  Fly   347 GNYGGNNQGFNNGGNNRRY 365
            |.||.::.. ::.|:.||:
Human   303 GGYGVSSSS-SSYGSGRRF 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb98DE	NP_524543.1	RRM1_hnRNPA_like	32..109	CDD:241022	50/76 (66%)
Hrb98DE	NP_524543.1	RRM_SF	123..195	CDD:302621	37/71 (52%)
HNRNPA1L2	NP_001011724.1	Globular A domain	4..94		55/84 (65%)
		RRM1_hnRNPA1	12..92	CDD:410154	51/79 (65%)
		Globular B domain	95..185		48/89 (54%)
		RRM_SF	105..184	CDD:418427	43/78 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..216		15/48 (31%)
		RNA-binding RGG-box	218..240		13/22 (59%)
		HnRNPA1	255..292	CDD:402981	18/42 (43%)
		Nuclear targeting sequence. /evidence=ECO:0000250	268..305		16/37 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..320		19/50 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6828
eggNOG	1	0.900	-	-		E33208_3BA81
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2209
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46466
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	1	1.000	-	-		FOG0000779
OrthoInspector	1	1.000	-	-		otm40611
orthoMCL	1	0.900	-	-		OOG6_103644
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.780