DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Noa36 and ZNF330

DIOPT Version :9

Sequence 1:	NP_651622.2	Gene:	Noa36 / 43384	FlyBaseID:	FBgn0026400	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_055302.1	Gene:	ZNF330 / 27309	HGNCID:	15462	Length:	320	Species:	Homo sapiens

Alignment Length:	305	Identity:	194/305 - (63%)
Similarity:	232/305 - (76%)	Gaps:	12/305 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPKKKTGQRKKAEKQKLRLKEIRSRE--VPLADLPCNAPMECDKCEKKQKSRAFCYFCQSIQRLP 63
            |||||||.|||||.::.|.|::|:..  :.||..||||.||||||:::||:|||||||.|:|:||
Human     1 MPKKKTGARKKAENRREREKQLRASRSTIDLAKHPCNASMECDKCQRRQKNRAFCYFCNSVQKLP 65

  Fly    64 ICAQCGKIKCMLKTGDCVVKHPGVYTTGLGMVGAICDFCEAWVCHGRKCLQNHACTCPLQNATCL 128
            |||||||.|||:|:.|||:||.|||:|||.||||||||||||||||||||..|||.|||.:|.|:
Human    66 ICAQCGKTKCMMKSSDCVIKHAGVYSTGLAMVGAICDFCEAWVCHGRKCLSTHACACPLTDAECV 130

  Fly   129 ECERGVWEHGGRIFKCSFCNGFLCEDDQFEHQASCQVLESENYKCQSCNKLGQYSCLRCKTCYCE 193
            |||||||:||||||.||||:.||||||||||||||||||:|.:||.|||:|||:||||||.|:|:
Human   131 ECERGVWDHGGRIFSCSFCHNFLCEDDQFEHQASCQVLEAETFKCVSCNRLGQHSCLRCKACFCD 195

  Fly   194 DHVRRKGFKYDKNKPIPCPKCNYDTSVTKDLSMSTRSHKFGRQQQGGNSDDEEGYGGYYGAGGSG 258
            ||.|.|.||.:|.|..|||||.::|..||||||||||.|||||..|...|...||..|:....|.
Human   196 DHTRSKVFKQEKGKQPPCPKCGHETQETKDLSMSTRSLKFGRQTGGEEGDGASGYDAYWKNLSSD 260

  Fly   259 YYGGAASGGYSYGGDDDEDESDGDYDDESDEDDDDDEEEDETTES 303
            .||..     || .|::|||    |:.|.||:::|:..:|..|||
Human   261 KYGDT-----SY-HDEEEDE----YEAEDDEEEEDEGRKDSDTES 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Noa36	NP_651622.2	NOA36	1..246	CDD:284042	173/246 (70%)
ZNF330	NP_055302.1	NOA36	1..268	CDD:368953	181/272 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		14/21 (67%)
		Nuclear localization signal. /evidence=ECO:0000255	3..11		6/7 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..320		46/100 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159583
Domainoid	1	1.000	425	1.000	Domainoid score	I611
eggNOG	1	0.900	-	-		E1_2C2D9
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8714
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1761
Isobase	1	0.950	-	0	Normalized mean entropy	S4450
OMA	1	1.010	-	-		QHG60117
OrthoDB	1	1.010	-	-		D398607at33208
OrthoFinder	1	1.000	-	-		FOG0007121
OrthoInspector	1	1.000	-	-		oto90889
orthoMCL	1	0.900	-	-		OOG6_108339
Panther	1	1.100	-	-	LDO	PTHR13214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4837
SonicParanoid	1	1.000	-	-		X5210
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750