DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Noa36 and ZNF836

DIOPT Version :9

Sequence 1:	NP_651622.2	Gene:	Noa36 / 43384	FlyBaseID:	FBgn0026400	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001096127.1	Gene:	ZNF836 / 162962	HGNCID:	34333	Length:	936	Species:	Homo sapiens

Alignment Length:	231	Identity:	53/231 - (22%)
Similarity:	84/231 - (36%)	Gaps:	53/231 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PMECDKCEKKQKSRAFCYFCQSIQRLPI---------CAQCGKIKCMLKTGDCVVKHPGVYTTGL 92
            |.:||||.|..|..:.      :.|..|         |.:|||:   .....|:|:|..::|
Human   497 PYKCDKCGKAFKQGSL------LTRHKIIHTREKRYQCGECGKV---FSENSCLVRHLRIHT--- 549

  Fly    93 GMVGAICDFC------------EAWVCHGRKCLQNHACTCPLQNATCLECERGVWEH-GGRIFKC 144
            |.....|:.|            ...:..|.|..|.:.|....:|.:||  .|.:..| |.:.:||
Human   550 GEQPYKCNVCGKVFNYSGNLSIHKRIHTGEKPFQCNECGTVFRNYSCL--ARHLRIHTGQKPYKC 612

  Fly   145 SFCNGFLCEDDQFEHQASCQVLESENYKCQSCNKL-GQYSCLRCKTCYCEDHVRRKGFKYDKNKP 208
            :.|.....:.....:.......| :.::|..|.|: ..||||          .|.:.. :...||
Human   613 NVCGKVFNDSGNLSNHKRIHTGE-KPFQCNECGKVFSYYSCL----------ARHRKI-HTGEKP 665

  Fly   209 IPCPKC----NYDTSVTKDLSMSTRSHKFGRQQQGG 240
            ..|..|    ...:|:||.|.:.|....:...:.||
Human   666 YKCNDCGKAYTQRSSLTKHLIIHTGEKPYNCNEFGG 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Noa36	NP_651622.2	NOA36	1..246	CDD:284042	53/231 (23%)
ZNF836	NP_001096127.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	220..240	CDD:275368
		C2H2 Zn finger	248..268	CDD:275368
		COG5048	272..648	CDD:227381	37/165 (22%)
		C2H2 Zn finger	276..296	CDD:275368
		zf-H2C2_2	288..313	CDD:290200
		C2H2 Zn finger	304..324	CDD:275368
		zf-H2C2_2	316..341	CDD:290200
		C2H2 Zn finger	332..352	CDD:275368
		zf-H2C2_2	345..369	CDD:290200
		C2H2 Zn finger	360..380	CDD:275368
		zf-H2C2_2	372..397	CDD:290200
		C2H2 Zn finger	388..408	CDD:275368
		zf-H2C2_2	400..425	CDD:290200
		C2H2 Zn finger	416..436	CDD:275368
		zf-H2C2_2	428..453	CDD:290200
		C2H2 Zn finger	444..464	CDD:275368
		zf-H2C2_2	457..481	CDD:290200
		C2H2 Zn finger	472..492	CDD:275368
		zf-H2C2_2	484..509	CDD:290200	6/11 (55%)
		COG5048	496..904	CDD:227381	53/231 (23%)
		C2H2 Zn finger	500..520	CDD:275368	8/25 (32%)
		C2H2 Zn finger	528..548	CDD:275368	7/22 (32%)
		zf-H2C2_2	541..565	CDD:290200	6/26 (23%)
		C2H2 Zn finger	556..576	CDD:275368	2/19 (11%)
		zf-H2C2_2	568..593	CDD:290200	4/24 (17%)
		C2H2 Zn finger	584..604	CDD:275368	5/21 (24%)
		zf-H2C2_2	597..620	CDD:290200	7/24 (29%)
		C2H2 Zn finger	612..632	CDD:275368	2/19 (11%)
		zf-H2C2_2	624..649	CDD:290200	4/25 (16%)
		C2H2 Zn finger	640..660	CDD:275368	8/30 (27%)
		zf-H2C2_2	653..677	CDD:290200	6/34 (18%)
		C2H2 Zn finger	668..688	CDD:275368	6/19 (32%)
		C2H2 Zn finger	696..714	CDD:275370	2/6 (33%)
		C2H2 Zn finger	724..744	CDD:275368
		C2H2 Zn finger	752..772	CDD:275368
		zf-H2C2_2	764..789	CDD:290200
		C2H2 Zn finger	780..800	CDD:275368
		zf-H2C2_2	793..815	CDD:290200
		C2H2 Zn finger	808..828	CDD:275368
		zf-H2C2_2	821..843	CDD:290200
		C2H2 Zn finger	836..856	CDD:275368
		zf-H2C2_2	849..873	CDD:290200
		C2H2 Zn finger	864..884	CDD:275368
		zf-H2C2_2	877..899	CDD:290200
		C2H2 Zn finger	892..912	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000