DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fkh and foxc1b

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_571804.1	Gene:	foxc1b / 79375	ZFINID:	ZDB-GENE-010302-2	Length:	433	Species:	Danio rerio

Alignment Length:	493	Identity:	144/493 - (29%)
Similarity:	205/493 - (41%)	Gaps:	135/493 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 TPSSMSYASMGSPLGNMGGCMAMSAASMSAAGLSGTYGAMPPGSREMETGSPNSLGRSRVDKPTT 201
            |.:...|..|.:|:    ...:.:.......|::..||...|..:      |..:
Zfish    28 TATGGGYTGMPAPM----SMYSHATHEQYPGGMARAYGPYAPAQQ------PKDM---------- 72

  Fly   202 YRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFND 266
                   .|||||||:||||||||:..:.:||:.||||||:.|||||.|:|.|||||||:||.|:
Zfish    73 -------VKPPYSYIALITMAIQNSSDKKITLNGIYQFIMERFPFYRDNKQGWQNSIRHNLSLNE 130

  Fly   267 CFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKD-----EKKEAIRQLHKSPSHS-S 325
            ||||:||...||||||:|||.|||.||||||.:|||::|||.     ||::..||...:|..: .
Zfish   131 CFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVLREKEDRDRQGKDNPGQACE 195

  Fly   326 LEATSPGK-KD-----------HEDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDA 378
            .:|..|.| :|           |:.:..:     |.:...:....:||::.:|    |.......
Zfish   196 QDAQQPVKLRDIKTENGACTPPHDSTPPL-----STVPKTESPDRSGGSACSG----SPQSQTPQ 251

  Fly   379 EALAMLHANAELCLSQQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLITDYHSSMHPLKQEPS 443
            :|.:|  ......|...|||.             .||.|..|  ..|..::..:|   |..| |:
Zfish   252 QAFSM--DTIMTGLRGSPQHA-------------AELPASRA--ALPGSVSLTYS---PTPQ-PA 295

  Fly   444 GYTPSSHPFSINRLLPTESKA--DIKMYDMSQYAGYNALSPLTNSHAALGQDSYYQSLGYHAPAG 506
            .|:|           |....|  ...|...|.|.|       ...|   |.|:..:   |.....
Zfish   296 HYSP-----------PCGQPATYHCNMQATSLYTG-------DRGH---GDDTLPE---YTNTTN 336

  Fly   507 TTSLXH-HQYPLAXGRAEQMLRSQQQQHLQQQ--------------HQQHQQQQQQHQLHQQQQQ 556
            .:|:.| ||           ..||:.|||||.              |.......||...|..::.
Zfish   337 ASSISHPHQ-----------SSSQESQHLQQNRLAPWYLNQSGELGHLSASYPGQQQNFHAVREM 390

  Fly   557 MQQSAQQLTSASNTPATSAKASGKAGSAS-----ASGS 589
            .:   .|..:.:::|.|.:.:...|..:|     |||:
Zfish   391 FE---TQRIALNSSPVTGSNSCQMAFPSSQPLYRASGA 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	9/71 (13%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	63/87 (72%)
foxc1b	NP_571804.1	Forkhead	74..160	CDD:278670	61/85 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..250		15/84 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..355		13/60 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910