DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fkh and foxf1

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_001039226.1	Gene:	foxf1 / 734087	XenbaseID:	XB-GENE-478922	Length:	373	Species:	Xenopus tropicalis

Alignment Length:	395	Identity:	106/395 - (26%)
Similarity:	164/395 - (41%)	Gaps:	99/395 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 AASMSAAGLSGTYGAMPPGSREMETGSPNSLGRSRVDKPTTYRRSYTHAKPPYSYISLITMAIQN 225
            ::.||||  :..:|..|.........:......:.:.:|         .|||||||:||.||||:
Frog    16 SSPMSAA--TDKHGGQPSVMESANCATKTKKTNAGIRRP---------EKPPYSYIALIVMAIQS 69

  Fly   226 NPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDS 290
            :||:.|||||||||:...|||:|.:.|.|:||:||:||.|:||:|:|:...:||||.:||:.|.|
Frog    70 SPTKRLTLSEIYQFLQSRFPFFRGSYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPAS 134

  Fly   291 GNMFENGCYLRRQKRFKDEKKEAIRQLHK-------------------------SPSHSSLEA-- 328
            ..|||.|.:.||.:.|: .|.:|::.::.                         .|:..||::
Frog   135 EFMFEEGSFRRRPRGFR-RKCQALKPMYSMMNGLGFNHIPETYSFQGASGTIACPPNSLSLDSGI 198

  Fly   329 -----------TSPGKKDHEDSHHMHHHHHSRL--------DHHQHHKEAGGASIAGVNVLSAAH 374
                       ...|...|..||...:..||.:        ..:.|| ::|...:.|..|:....
Frog   199 GMMNGHLPSNVDGMGLSGHPVSHIAANGGHSYMGSCTGSSGGDYSHH-DSGSPLLGGGGVMEPHS 262

  Fly   375 SKDAEALAMLHANAELCLSQQPQHV------PTHHHHQHHQLQQEELSAMMANRCHPSLITDYHS 433
            ...:.|.|...:.:...:.|||...      |.......|.|.|..|                |.
Frog   263 VYSSPASAWAPSASTPYIKQQPLSPCNSAANPLSSSLSSHSLDQSYL----------------HQ 311

  Fly   434 SMHPLKQEPSGYTPSSHPFSINRLLPTESKADIKMYDMSQYA-GYNALSPLTNSHAALGQDSYY- 496
            :.|....|..|             :|........|.|..::. .:||::. ::.|:  |..|||
Frog   312 NSHNTASELQG-------------IPRYHSQSPSMNDRKEFVFSFNAMAS-SSMHS--GSGSYYH 360

  Fly   497 QSLGY 501
            |.:||
Frog   361 QQVGY 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	7/47 (15%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	52/87 (60%)
foxf1	NP_001039226.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		6/36 (17%)
		Forkhead	53..139	CDD:365978	50/85 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..255		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	283..306		5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910