DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fkh and fd102C

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_651951.1	Gene:	fd102C / 43843	FlyBaseID:	FBgn0039937	Length:	599	Species:	Drosophila melanogaster

Alignment Length:	580	Identity:	135/580 - (23%)
Similarity:	221/580 - (38%)	Gaps:	138/580 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 GNMGGCMAMSAAS-----MSAAGLSGTYGAMPPGSREMETGSPNSL--GRSRVDKPTTYRRSYTH 208
            |..||    |.||     :|..|..|: |::|..:| |...|..||  ...|:.:|       ..
  Fly    76 GGTGG----SGASAPWLHLSPYGHHGS-GSLPSVNR-MAALSTISLFPQTQRIFQP-------EE 127

  Fly   209 AKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKIPR 273
            .||.:|||.||.|||.::....|.||:|||:|:|.:|::|.....|:|||||:||.||||:|..|
  Fly   128 PKPQHSYIGLIAMAILSSTDMKLVLSDIYQYILDNYPYFRSRGPGWRNSIRHNLSLNDCFIKSGR 192

  Fly   274 TPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIR---QLHKSPSHSSLEATSPGKKD 335
            :.:  |||.:|.:||.:...|..|.:.||:.:.|..|...:.   ....|||...|:.|:|....
  Fly   193 SAN--GKGHYWAIHPANMEDFRKGDFRRRKAQRKVRKHMGLSVDDASTDSPSPPPLDLTTPPPPS 255

  Fly   336 HEDSHHMHHHHHSRL--DHHQHH--KEAGGASIAGVNVLSAAHSKDAEALAMLHANA-ELCLSQQ 395
            .:.:..:     |.|  .:|||:  :....:|..|:    ..:|....||.|....| .|..:.|
  Fly   256 SQSALQL-----SALGYPYHQHYIGQFFNRSSAPGM----THYSPPDPALLMQRQEANNLDQTIQ 311

  Fly   396 P-QHVPTHHHHQHHQLQQEELSAMMANRCHPSLITDYHSSMHPLKQEPSGYTPSSHPFSINRLLP 459
            | |....|.||||........:..:||....:                     ....|.:..||
  Fly   312 PTQLQQPHSHHQHFAYINSTTTTTIANMFSQT---------------------RKRQFDVASLL- 354

  Fly   460 TESKADIKMYDMSQYAGYNALSPLTNSHAALGQDSYYQSLGYHAPAGTTSLXHHQYPLAXGRAEQ 524
               ..|:::.|:......::::|.|:                   |.||:. ||..     ..:|
  Fly   355 ---APDVQIVDIVSEDQESSVTPTTS-------------------ARTTTQTHHTV-----ITKQ 392

  Fly   525 MLRSQQQQHLQQQHQQHQ-------------------QQQQQHQLHQQQQQMQQSAQQLTSASNT 570
            .:..:....|::..|...                   .....:...:.:::.:.:.:|:.|..:.
  Fly   393 TIHREVVLGLEKPVQDADIDADIDVEVNVDVVDDSIIPDTDSYTDGEDRKKTRGTLKQIFSIEDN 457

  Fly   571 PATSAKASGKAGSASAS-------------------GSGSGSGSGSGSNYSQKLQQQHQQQQQ-Q 615
              .|....|:..|..|.                   .|.:....||.|:       ||::... :
  Fly   458 --NSYLIDGRLSSFDADPDHDPDHDPEDLEQHNFSIASSAARSLGSSSS-------QHEESSSLE 513

  Fly   616 QAAAQQQHHQQQQQLLQEL-QEDSSNITSDLSEEQLQQHQAAQQQLYNNYQQYAAAAGYR 674
            :...|:.....|..|:..: ...:|.::..:|:..|:.:|..|..|...|..|.|||..|
  Fly   514 ECPIQECIVAPQTALISSMATAKTSTLSVPISDAYLELNQVDQHMLSRYYGSYIAAAARR 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	18/64 (28%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	41/87 (47%)
fd102C	NP_651951.1	Forkhead	129..213	CDD:278670	41/85 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445513
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11829
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940