DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fkh and foxa2

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_989423.1	Gene:	foxa2 / 395063	XenbaseID:	XB-GENE-480476	Length:	434	Species:	Xenopus tropicalis

Alignment Length:	471	Identity:	187/471 - (39%)
Similarity:	255/471 - (54%)	Gaps:	115/471 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DSAAAVASMSASMS-------ASMSA-SMNASMN-GSMGAAAMN-----SMGGNCMTPSSMSYAS 145
            ::.::|.:|:|.:|       .|||| |.:|:|. |||..:.:|     |:.|  |:|.:.:...
Frog    23 EAYSSVGNMNAGLSMNPMNTYMSMSAMSTSANMTAGSMNMSYVNTGMSPSLTG--MSPGTGAMTG 85

  Fly   146 MGSPLGNMGGCMAMSAASMSAAGLSGTYGAMPPGSREMETGSP----NSLGRSRVDKPTTYRRSY 206
            ||:.:.:|...::.|.:.|||...|  ..|:.|.: .|.:.||    :::.|||  .|.||||||
Frog    86 MGTGVASMASHLSPSMSPMSAQATS--MNALAPYT-NMNSMSPIYGQSNINRSR--DPKTYRRSY 145

  Fly   207 THAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKI 271
            ||||||||||||||||||.:|.:|||||||||:|||||||||||||||||||||||||||||:|:
Frog   146 THAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKV 210

  Fly   272 PRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQ-----LHK------SPSHSS 325
            ||:|||||||||||||||||||||||||||||||||.|||.::|:     |.:      |.::||
Frog   211 PRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKKPSLREGGGKKLSEGSSSVGSAANSS 275

  Fly   326 LEATSPGKKDHEDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAMLHANAEL 390
            .|::...:..|..|........|.:|                       .|.::.|:..||.:.
Frog   276 SESSVGNESPHSSSSPCQEQKRSLVD-----------------------MKSSQGLSPDHAASP- 316

  Fly   391 CLSQQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLITDYHSSMHPLKQEPSGYTPSSHPFSIN 455
              :.|.||:.:.||            :::::.....|..::|.|.             :||||||
Frog   317 --ASQAQHLLSQHH------------SVLSHEAQSHLKPEHHYSF-------------NHPFSIN 354

  Fly   456 RLLPTES--------------KADIKMYD-MSQYAGYN-------ALSPLTN-----SHAALGQD 493
            .|:.:|.              |.|:|.|: :..|:||.       |:|.:||     |.......
Frog   355 NLMSSEQQHHHHHHHNHHHHHKMDLKAYEQVMHYSGYGSPMTGSLAMSTVTNKSGLESSPISSDT 419

  Fly   494 SYYQSLGYHAPAGTTS 509
            ||||.: |..|...:|
Frog   420 SYYQGV-YSRPIMNSS 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	32/98 (33%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	79/87 (91%)
foxa2	NP_989423.1	Forkhead_N	17..148	CDD:369872	43/131 (33%)
		FH	149..237	CDD:214627	79/87 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..339		21/127 (17%)
		HNF_C	349..423	CDD:370449	22/73 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3596
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	266	1.000	Inparanoid score	I2969
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1181467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm48067
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4570
SonicParanoid	1	1.000	-	-		X1772
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100