DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fkh and foxa1

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_989419.1	Gene:	foxa1 / 395059	XenbaseID:	XB-GENE-487352	Length:	428	Species:	Xenopus tropicalis

Alignment Length:	487	Identity:	192/487 - (39%)
Similarity:	255/487 - (52%)	Gaps:	97/487 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 NNNPNPTSNGGSMSPLARSAYTMNSMG--LPVGGMSSVSPQAAATFSSSVLDSAAAVASMSASMS 108
            :|....|....|..|::.....:.||.  :.:..|||.|...|.:|:.|..:|... |.:|.|..
Frog    16 SNYYQDTQEAYSSVPVSNMTQGLASMNTYMTMNPMSSSSNMTAGSFNMSYANSGLG-AGLSPSGM 79

  Fly   109 ASMSASMNASMNGSMGAAAMNSMGGNCMTPSSMSYASMGSPLGNMGGCMAMSAASMSAAGLSGTY 173
            :.|.|...::||| || :.::|| |..::||||:               ||||...|...||  |
Frog    80 SGMGAGSASAMNG-MG-SGVSSM-GTALSPSSMN---------------AMSAQQASINSLS--Y 124

  Fly   174 GAMPPGSREMETGSPNSLGRSRVDKPTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQ 238
            ..|.||...|..| |:::.|:|..|  |:||||.|||||||||||||||||..|::|||||||||
Frog   125 SGMNPGMSPMAYG-PSNMNRTRDTK--TFRRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQ 186

  Fly   239 FIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQ 303
            :|||||.:||||||||||||||||||||||||:.|:||||||||:||||||||||||||||||||
Frog   187 WIMDLFLYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQ 251

  Fly   304 KRFKDEKKEAIRQLHKSPSHSSLEATSPGKKD---HEDSHHMHHHHHSRLDHHQHHKEAGGASIA 365
            ||||.||::..:            .:..|:||   .....|..|...|::|        ..:|::
Frog   252 KRFKCEKQQGGK------------GSQDGRKDVSGPSSPLHRVHGKSSQMD--------SSSSMS 296

  Fly   366 GVNVLSAAHSKDAEALAMLHANAEL--CLSQQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLI 428
            .       .|...::|....:|.|:  .::..|..:.:|.:|..|.|         |:..|..|.
Frog   297 N-------PSSSPQSLEHNGSNGEMKPQVAAGPSPLSSHQNHSTHSL---------AHETHIHLK 345

  Fly   429 TDYHSSMHPLKQEPSGYTPSSHPFSINRLLPT---ESKADIKMYD--MSQYAGYNALSP----LT 484
            .|.|.|.             :||||||.|:.:   :.|.|.|.|:  :.||:.|:...|    .:
Frog   346 GDPHYSF-------------NHPFSINNLMSSSEQQHKLDFKAYEQALQQYSSYSGGLPGMPLGS 397

  Fly   485 NSHAALG-------QDSYYQSLGYHAPAGTTS 509
            .|.|..|       :.:|||.: |..|...||
Frog   398 PSMAGRGSIEPSALEPTYYQGV-YSRPVLNTS 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	33/88 (38%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	76/87 (87%)
foxa1	NP_989419.1	Forkhead_N	17..157	CDD:369872	53/163 (33%)
		FH	158..246	CDD:214627	76/87 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..337		19/115 (17%)
		HNF_C	354..417	CDD:370449	19/62 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12250
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	266	1.000	Inparanoid score	I2969
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1181467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48067
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1772
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.070