DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fkh and FOXA2

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_068556.2	Gene:	FOXA2 / 3170	HGNCID:	5022	Length:	463	Species:	Homo sapiens

Alignment Length:	493	Identity:	200/493 - (40%)
Similarity:	251/493 - (50%)	Gaps:	109/493 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SAYTMNSMGLPVGGMSSVSPQAAATFSSSVLDSAAAVASMSASMSASMSASMNASMNGSMGAAAM 128
            |...||: ||.:.||::....:||...|...:.:|...:||:.:.|.||.|: |.|  |.||.||
Human    33 SVSNMNA-GLGMNGMNTYMSMSAAAMGSGSGNMSAGSMNMSSYVGAGMSPSL-AGM--SPGAGAM 93

  Fly   129 NSMGGNCMTPSSMSYASMG-------SPLGNMGGCMAMSAASMSAAGLSGTYGAMPPGSREMETG 186
            ..|||:.   .:...|.||       ||||...               :|..|.:.|.: .|.:.
Human    94 AGMGGSA---GAAGVAGMGPHLSPSLSPLGGQA---------------AGAMGGLAPYA-NMNSM 139

  Fly   187 SP--NSLGRSRVDKPTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQ 249
            ||  ...|.||...|.||||||||||||||||||||||||.:|.:|||||||||:||||||||||
Human   140 SPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQ 204

  Fly   250 NQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAI 314
            |||||||||||||||||||:|:||:|||||||||||||||||||||||||||||||||.||:.|:
Human   205 NQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKQLAL 269

  Fly   315 RQ------------LHKSPSHSSL-EATSPGKKDHEDSHHMHHHHHSRLDHHQHHKEAGGASIAG 366
            ::            .....|.:.| ||..|..:....:    ...||.....|.||..|...:.|
Human   270 KEAAGAAGSGKKAAAGAQASQAQLGEAAGPASETPAGT----ESPHSSASPCQEHKRGGLGELKG 330

  Fly   367 VNVLSAAHSKDAEALAMLHANAELCLSQQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLITDY 431
            .         .|.||:            .|:..|:...      ||:..:.::....||.|..:.
Human   331 T---------PAAALS------------PPEPAPSPGQ------QQQAAAHLLGPPHHPGLPPEA 368

  Fly   432 HSSMHPLKQEPSGYTPSSHPFSINRLLPTES------------KADIKMYD-MSQYAGYN----- 478
            |     ||  |..:...:||||||.|:.:|.            |.|:|.|: :..|.||.
Human   369 H-----LK--PEHHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDLKAYEQVMHYPGYGSPMPG 426

  Fly   479 --ALSPLTN----SHAALGQD-SYYQSLGYHAPAGTTS 509
              |:.|:||    ..:.|..| ||||.: |..|...:|
Human   427 SLAMGPVTNKTGLDASPLAADTSYYQGV-YSRPIMNSS 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	32/97 (33%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	79/87 (91%)
FOXA2	NP_068556.2	Forkhead_N	23..164	CDD:369872	51/153 (33%)
		FH_FOXA2	163..264	CDD:410813	92/100 (92%)
		HNF_C	380..452	CDD:401339	23/71 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159761
Domainoid	1	1.000	175	1.000	Domainoid score	I3657
eggNOG	1	0.900	-	-		E2759_KOG3563
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2997
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1181467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm40869
orthoMCL	1	0.900	-	-		OOG6_105963
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4570
SonicParanoid	1	1.000	-	-		X1772
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.830