DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fkh and foxa1

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_571359.2	Gene:	foxa1 / 30541	ZFINID:	ZDB-GENE-990415-78	Length:	427	Species:	Danio rerio

Alignment Length:	493	Identity:	198/493 - (40%)
Similarity:	253/493 - (51%)	Gaps:	125/493 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 NPTSNGGSMSPLARSAYTMNS-MGLPVGGMSSVSPQAAATFSSSVLDSAAAVASMSASMSASMSA 113
            :|.:| .||:|...|...||| ||:...|          ..:||..:.:.|..::.|.:|.
Zfish    27 SPMTN-SSMNPGLSSMNNMNSYMGMSTSG----------NMTSSSFNMSYANPALGAGLSP---- 76

  Fly   114 SMNASMNGSMGAAAMNSMGGNCMTPSSMSYASMGSPL--GNMGGCMAMSAASMSAAGLSGTYGAM 176
               .:|.|.....|||.|||        ..:|||:.|  .|:.   ||:|...|...|: .|.:|
Zfish    77 ---GTMAGMPTGGAMNGMGG--------GVSSMGTALSPSNLN---AMTAQHSSMNALN-PYTSM 126

  Fly   177 PPGSREMETGSPNSLGRSRVDKPTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIM 241
            .|....|....|| |.|:|.:|  |:||||.|||||||||||||||||..|::|||||||||:||
Zfish   127 SPTMSSMTYAQPN-LNRARDNK--TFRRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIM 188

  Fly   242 DLFPFYRQNQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRF 306
            ||||:||||||||||||||||||||||||:.|:||||||||:|||||||||||||||||||||||
Zfish   189 DLFPYYRQNQQRWQNSIRHSLSFNDCFVKVSRSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRF 253

  Fly   307 KDEKK-------EAIRQLHKSPSHSSLEATSPGKKDHEDSHHMHHHHHS----RLDHHQHHKEAG 360
            |.:||       |..|: ..|.|.|....::..|..|.||..:...:.|    .|||.      .
Zfish   254 KCDKKLPDGKRSEGKRE-QSSGSGSPASDSTSSKPVHMDSSSITSSNQSSSPPSLDHR------S 311

  Fly   361 GASIAGVNVLSAAHSKDAEALAMLHANAELCLSQQPQHVPTHHHHQHHQLQQEELSAMMANRCHP 425
            |:|                      ||:|| .|..||                         .||
Zfish   312 GSS----------------------ANSEL-KSGGPQ-------------------------VHP 328

  Fly   426 --SLITDYHSSMHP----LKQEPSGYTPSSHPFSINRLLPT---ESKADIKMYDMS-QYAGY-NA 479
              :.::..||..|.    ||.:|  :...:||||||.|:.:   :.|.::|.|:.: ||:.| :.
Zfish   329 VSTSLSSLHSMAHESQLHLKGDP--HYSFNHPFSINNLMSSSEQQHKLELKAYEQALQYSSYGSG 391

  Fly   480 LS---PLT-----NSHAALGQDSYYQSLGYHAPAGTTS 509
            :|   |:.     :..||| :.||||.: |..|...||
Zfish   392 MSSNLPMAGRASMDPSAAL-EASYYQGV-YSRPVLNTS 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	32/90 (36%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	77/87 (89%)
foxa1	NP_571359.2	Forkhead_N	17..156	CDD:254796	50/161 (31%)
		FH	157..245	CDD:214627	77/87 (89%)
		HNF_C	357..416	CDD:286443	20/59 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3596
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	268	1.000	Inparanoid score	I3003
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1181467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26252
orthoMCL	1	0.900	-	-		OOG6_105963
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4570
SonicParanoid	1	1.000	-	-		X1772
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.000