DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fkh and Foxd3

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	XP_008762182.2	Gene:	Foxd3 / 29203	RGDID:	621715	Length:	469	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	141/493 - (28%)
Similarity:	184/493 - (37%)	Gaps:	161/493 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 PSSMSYASMGSPLGNMGGCMAMSAASMSAAGLSGTYGAMPPGSREMETG--SPNSLGRSRVDKPT 200
            |.:::..|..:..||..|.   ..|.....|.....|...||:....||  :||....|.|
  Rat    73 PQALALPSEATGPGNDTGA---PEADGCKGGEDAVTGGGGPGAGGGATGGLTPNKPKNSLV---- 130

  Fly   201 TYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFN 265
                     |||||||:||||||..:|.:.||||.|.:||.:.||:||:....|||||||:||.|
  Rat   131 ---------KPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLN 186

  Fly   266 DCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQ-----LHKSPSHSS 325
            ||||||||.|..||||::|||.|.|.:||:||.:|||:||||..::|.:|:     :....::|.
  Rat   187 DCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLREQTALMMQSFGAYSL 251

  Fly   326 LEATSPGKKDHEDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAMLHANAEL 390
            ..|.|.|........|                   .|:.||      |:|..|.|.|...|.|
  Rat   252 AAAASAGPYGRPYGLH-------------------PAAAAG------AYSHPAAAAAAAAAAA-- 289

  Fly   391 CLSQQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLITDYHSSMHPLKQEPSGYTPSSHPFSIN 455
              .|.|..:|.                 :|....|::         ||.  |||        .:.
  Rat   290 --LQYPYALPP-----------------VAPVLPPAV---------PLL--PSG--------ELG 316

  Fly   456 RLLPTESKADIKMYDMSQYAGYNALSPLTNSHAALGQDSYYQSLGYHAPAGTTSLXHHQYPLAXG 520
            |          |........|.:....|....||..      :.|....||||||.
  Rat   317 R----------KAAAFGSQLGPSLQLQLNTLGAAAA------AAGTAGAAGTTSLI--------- 356

  Fly   521 RAEQMLRSQQQQHLQQQHQQHQQQQQQHQLHQQQQQMQQSAQQLTSASNT----PATSAKASGKA 581
                                               :.:.||:...|..|.    ||....::|..
  Rat   357 -----------------------------------KSEPSARPSFSIENIIGAGPAAPGSSAGGG 386

  Fly   582 GSASASGSGSGSGSGS---------GSNYSQKLQQQHQ 610
            |||..:|.|.|||.|.         |:..|..|...||
  Rat   387 GSAGGAGGGGGSGGGGSAQSFLRPPGTVQSAALMATHQ 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	16/72 (22%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	56/87 (64%)
Foxd3	XP_008762182.2	FH_FOXD3	130..226	CDD:410821	61/108 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910