DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fkh and FOXB1

DIOPT Version :9

Sequence 1:	NP_001263038.1	Gene:	fkh / 43383	FlyBaseID:	FBgn0000659	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_036314.2	Gene:	FOXB1 / 27023	HGNCID:	3799	Length:	325	Species:	Homo sapiens

Alignment Length:	331	Identity:	115/331 - (34%)
Similarity:	151/331 - (45%)	Gaps:	108/331 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 PTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLS 263
            |...|.:|:..|||||||||..||||::|.:||.|||||:||||.||:||:|.||||||:||:||
Human     2 PRPGRNTYSDQKPPYSYISLTAMAIQSSPEKMLPLSEIYKFIMDRFPYYRENTQRWQNSLRHNLS 66

  Fly   264 FNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSSLEA 328
            |||||:||||.||:|||||||.|||..|:|||||.:|||:||||..|.:     |.:|
Human    67 FNDCFIKIPRRPDQPGKGSFWALHPSCGDMFENGSFLRRRKRFKVLKSD-----HLAP------- 119

  Fly   329 TSPGKKDHEDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAMLHANAELCLS 393
                                                          ||.|:|...|...|:|
Human   120 ----------------------------------------------SKPADAAQYLQQQAKL--- 135

  Fly   394 QQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLITDYHSSMHPL--KQEPSGYTPSSHPFSINR 456
                                .|||:.|:..|   :....::.:.|  ..:|||:   .|||:|..
Human   136 --------------------RLSALAASGTH---LPQMPAAAYNLGGVAQPSGF---KHPFAIEN 174

  Fly   457 LLPTESKADIKMYDMSQYAGYNALSP----------LTNSHAALGQ--DSYYQSLGYHAPAGTTS 509
            ::..|       |.|.....::|:.|          ||...::||.  ...|.|.|....|...|
Human   175 IIARE-------YKMPGGLAFSAMQPVPAAYPLPNQLTTMGSSLGTGWPHVYGSAGMIDSATPIS 232

  Fly   510 LXHHQY 515
            : ...|
Human   233 MASGDY 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fkh	NP_001263038.1	Forkhead_N	<120..209	CDD:254796	3/9 (33%)
fkh	NP_001263038.1	FH	210..298	CDD:214627	66/87 (76%)
FOXB1	NP_036314.2	FH_FOXB2	1..110	CDD:410817	75/107 (70%)
FOXB1	NP_036314.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910